1. Funding Opportunities at the NIH : Minority Serving Institutions and small schools
Avrom Caplan, PhD
Associate University Dean for Research
The City University of New York

2. National Institutes of Health
Office of the Director
National Institute
on Aging
National Institute
on Alcohol Abuse
and Alcoholism
National Institute
of Allergy and
Infectious Diseases
National Institute
of Arthritis and
Musculoskeletal
and Skin Diseases
National Cancer
Institute
National Institute
of Child Health
and Human
Development
National Institute on
Deafness and Other
Communication
Disorders
National Institute
of Dental and
Craniofacial
Research
National Institute
of Diabetes and
Digestive and
Kidney Diseases
National Institute
on Drug Abuse
National Institute
of Environmental
Health Sciences
National Eye
Institute
National Institute
of General
Medical Sciences
National Heart,
Lung, and Blood
Institute
National Human
Genome Research
Institute
National Institute
of Mental Health
National Institute
of Neurological
Disorders and
Stroke
National Institute
of Nursing Research
National Institute of
Biomedical Imaging
and Bioengineering
National Center
for Complementary
and Alternative
Medicine
Fogarty
International
Center
National Center
for Research
Resources
National Library
of Medicine
National Center on
Minority Health and
Health Disparities
Clinical Center
Center for
Information
Technology
Center for
Scientific Review

3. MBRS – minority biomedical research support
• SCORE – faculty support for biomedical and behavioral research – 3 different mechanisms for support, with each funding new applications annually.
• RISE – progam for student support – for all students at an MSI
• IMSD – progam for student support
• MARC – progam for honors student support – for URMS

4. MBRS – minority biomedical research support Research Initiative for Scientific Enhancement (RISE)
• developmental program to enhance undergraduate research at an MSI
• goal is to increase number of UR minority students advancing to PhD in biomedical and behavioral research. Also, the goal is to ensure that master’s students go onto PhD and for PhD students to graduate
• one RISE grant per institution
• expected to include salary support for undergraduates and plans for curricula enhancement; rcr training etc; rennovation (limited)

5. MBRS – minority biomedical research support Initiative for maximizing student development (IMSD)
• similar to RISE but don’t have to be MSI •
The program offers an opportunity to develop new or expand existing effective academic developmental programs, including student research internships, in order to prepare students from underrepresented groups for competitive research careers and leadership positions in the biomedical or behavioral sciences.
• one IMSD grant per institution (can’t have RISE and IMSD)
• expected to include salary support for undergraduates and plans for curricula enhancement; rcr training etc; rennovation (limited)

6. SCORE PROGRAM
• 25 grant maximum per institution; only full time faculty can apply
• Review is by special emphasis panels rather than standing study sections.
No specific payline
• must include developmental objective of the grant will increase research competitiveness as part of biosketch including plans for transition to R-type funding.
• application dates are: Jan 25, May 25 and Sept 25
• Chief MBRS branch is Hinda Zlotnik – ;

7. SCORE PROGRAM – SC1
SC1 – RO1-like; 12 page research strategy; up to 5 years; K/yr.
Collaboration with RO1 funded investigators encouraged
Only 1 PI and 1 renewal application allowed (ie 10 years)
Postdocs are allowed on SC1 but not SC2 or SC3
No student stipends; tuition or journal subscriptions

8. SCORE PROGRAM – SC2 – for early investigators
SC2 – testing new idea; preliminary data; switching to a new field. 3 yr max; 50K-100K/yr w/300K max. No renewal. 6 page research strategy
You need a mentor for SC2 – mentor activities must be described
Only 1 PI; no preliminary data needed….
No postdocs; student stipends; tuition or journal subscriptions

9. SCORE PROGRAM – SC3
SC3 – seek to continue competitive research of limited scope encouraged to participate in collaborations w/RO1 funded scientists.
renewable (developmental – no Co-Pis).
4 50K- 75K

10. Academic Research Enhancement Award - AREA (R15)
Must have less than $6 million in support in 4 out of the last 7 years
• Biomedical and Behavioral research
• expose undergraduate students to research
• improve research environment at the college
• research grant not a training grant
- describe student activities; student profiles – put these in environment and budget justification sections
• 3 yrs, $300,000 total; 12 page
• due dates are Feb. 25, June 25 and Oct. 25
• preliminary data not required but recommended
• letter of institutional support is a benefit
• multiple PIs; renewable
• reviewed in regular study section – payline ~19%

11. The New Research Strategy (the old Research Plan)
Specific aims 1 page
Research Strategy 12 pages for R01
- Significance, Innovation and Approach
How to write a 12 page grant
Significance needs to describe what will be the result of the research assuming everything works – what is the NIH buying?
Half a page??
Innovation must described what’s new?
Approach – put background into the intro to each aim; needs to include preliminary data
Aligned with review criteria

12. Formatted Reviewer Critiques

13. NIH grants: Review Criteria
Significance
Does the project address an important problem or a critical barrier to progress in
the field? If the aims of the project are achieved, how will scientific knowledge,
technical capability, and/or clinical practice be improved? How will successful
completion of the aims change the concepts, methods, technologies, treatments,
services, or preventative interventions that drive this field?

14. NIH grants: Review Criteria
Innovation
Does the application challenge and seek to shift current research or clinical
practice paradigms by utilizing novel theoretical concepts, approaches or
methodologies, instrumentation, or interventions? Are the concepts,
approaches or methodologies, instrumentation, or interventions novel to
one field of research or novel in a broad sense? Is a refinement,
improvement, or new application of theoretical concepts, approaches or
methodologies, instrumentation, or interventions proposed?

15. NIH grants: Review Criteria
Approach Are the overall strategy, methodology, and analyses well-reasoned and appropriate to accomplish the specific aims of the project? Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility and will particularly risky aspects be managed? If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the scientific goals and research strategy proposed?

16. NIH grants: Review Criteria
Investigator(s)
Are the PD/PIs, collaborators, and other researchers well suited to the
project? If Early Stage Investigators or New Investigators, or in the early
stages of independent careers, do they have appropriate experience and
training? If established, have they demonstrated an ongoing record of
accomplishments that have advanced their field(s)? If the project is
collaborative or multi-PD/PI, do the investigators have complementary and
integrated expertise; are their leadership approach, governance and
organizational structure appropriate for the project?
You can address this in your personal statement for the Biosketch

17. NIH biosketch
Personal statement. Briefly describe why your experience and qualifications make you particularly well-suited for your role (e.g., PD/PI, mentor) in the project that is the subject of the application.

18. NIH biosketch
NIH encourages applicants to limit the list of selected peer-reviewed publications or manuscripts in press to no more than 15. Do not include manuscripts submitted or in preparation. The individual may choose to include selected publications based on recent, importance to the field, and/or relevance to the proposed research
Nih now wants a PubMed central reference number if publication was financed by prior NIH support

19. NIH biosketch
Research Support. List both selected ongoing and completed research projects for the past three years (Federal or non-Federally-supported). Begin with the projects that are most relevant to the research proposed in the application. Briefly indicate the overall goals of the projects and responsibilities of the key person identified on the Biographical Sketch. Do not include number of person months or direct costs.
Do not confuse "Research Support" with "Other Support." Though they sound similar, these parts of the application are distinctly different. As part of the biosketch section of the application, "Research Support" highlights your accomplishments, and those of your colleagues, as scientists.

20. NIH grants: Review Criteria
Environment. Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?
Scientific environment: your colleagues – what is the culture in which you work?
- how interactive is your department; division
- what is the level of funding?
- physical environment
Unique features: John Jay ???

21. Resources Page
This information is used to assess the capability of the organizational resources available to perform the effort proposed.
• Identify the facilities to be used (laboratory, clinical, animal, computer, office, other). If appropriate, indicate their capacities, pertinent capabilities, relative proximity and extent of availability to the project. Describe only those resources that are directly applicable to the proposed work. Provide any information describing the Other Resources available to the project (e.g., machine shop, electronic shop) and the extent to which they would be available to the project.
This part is easy….

22. Resources Page
• Describe how the scientific environment in which the research will be done contributes to the probability of success (e.g., institutional support, physical resources, and intellectual rapport). In describing the scientific environment in which the work will be done, discuss ways in which the proposed studies will benefit from unique features of the scientific environment or subject populations or will employ useful collaborative arrangements.
• For Early Stage Investigators, describe institutional investment in the success of the investigator, e.g., resources for classes, travel, training; collegial support such as career enrichment programs, assistance and guidance in the supervision of trainees involved with the ESIs project, and availability of organized peer groups; logistical support such as administrative management and oversight and best practices training; and financial support such as protected time for research with salary support.

23. Resources Page
institutional support:
- space and arrangement of labs.
- how many other funded labs
physical resources:
- what core facilities are available to you at your college and at CUNY as a whole?
- include RCMI resources
intellectual rapport:
- how many scientists working in your field are in your department?
- how do you interact (seminars/lab mtgs)
- how about across CUNY?

24. The SCORE and RO1 instructions seem mutually exclusive…?
Resources Page
• SCORE instructions:
Institutions with well developed environments for the conduct of research and/or research training and significant support from NIH RO1 or equivalent are generally not suitable applicants for the SCORE program.
• RO1 instructions:
Will the scientific environment in which the work will be done contribute to the probability of success? Are the institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements?
The SCORE and RO1 instructions seem mutually exclusive…?

25. Formatted Reviewer Critiques

26. NIH grants: Review Criteria
Overall Evaluation/Impact*
Based upon consideration of the 5 core review criteria (& any additional pertinent review criteria), reviewers provide an overall impact statement and score to reflect their assessment of the likelihood for the project to exert a sustained, powerful influence on the research field(s) involved.
An application need not be strong in all categories to be judged likely to have a major scientific impact. (For example, a project may propose to carry out important work that by its nature is not innovative, but is essential to move a field forward, or improve clinical decisions or outcomes).
*It IS NOT the mean score of the the other 5 criteria

27. NIH grants: Review Criteria
Overall impact
Core review criteria
- Significance – assumes all aims achieved
- Investigator – that means you!
- Innovation - so whats new?
- Approach – finally, the science itself
- Environment – that means your dept., college and CUNY
These apply to RO1, R21, RO3, SC1, SC2 and SC3