1. ERT 207-Analytical Chemistry Lecturers: Dr. Saleha Shamsudin (Coordinator) Assoc. Prof. Dr. Mohamed Zulkali bin Mohamed Daud

2. Course synopsis : This course introduces and discusses the basic principle of analytical chemistry that covers data analysis and interpretation. Basic statistics and the utilization of statistics are applied in most of the analytical methods. In this course students are able to apply classical analytical methods such as gravimetry and titrimetry as well as applying modern methods in analytical chemistry such as chromatographic and spectroscopic technique.

3. Learning Outcomes: At the end of the course, students are expected to be: 1. Ability to calculate and perform the correct statistical method for data analytical and to remember the steps in quantitative analysis. 2. Ability to classify and use separation techniques and gravimetric methods for mass determination. 3. Ability to differentiate and to calculate concentration of analytes of various titrimetric methods (acid-base, complexation, redox, and precipitation). 4. Ability to apply the chromatography principles and to interpret and calculate peak height for concentration determination. 5. Ability to understand the spectroscopic principles and to interpret and calculate concentration.

4. List of experiments : 1.The potentiometric titration of an acid. 2.Determination of water hardness by complexometric titration. 3.Determination of limonene concentration in citrus fruit extracts by gas chromatography. 4.Interpretation of spectra of an unknown sample using Fourier transform-infrared (FTIR) spectroscopy. 5.Determination of active drug substance in a pharmaceutical formulation using ultraviolet and visible spectrometry (uv/vis).

5. Learning approach : Lecture : 42 hours (60 %) Laboratory : 20 hours (28.6 %) Tutorial : 8 hours (11.4 %) Learning approach : Lecture : 42 hours (60 %) Laboratory : 20 hours (28.6 %) Tutorial : 8 hours (11.4 %) Evaluation contribution: Peperiksaan / Examination : 70 % Mid Term Examination 1 = 10 % Mid Term Examination 2 = 10 % Final Examination = 50 % Penilaian berterusan / Continual assessment : 30 % Laboratories = 15 % Assignments / Quizzes = 15 % Evaluation contribution: Peperiksaan / Examination : 70 % Mid Term Examination 1 = 10 % Mid Term Examination 2 = 10 % Final Examination = 50 % Penilaian berterusan / Continual assessment : 30 % Laboratories = 15 % Assignments / Quizzes = 15 %

7. List of text books and references : Buku Teks / Text book(s): Gary D. Christian (2004). Analytical Chemistry. 6 th Edition. Publisher: John Wiley & Sons, Inc. Buku Rujukan / Reference books: David Harvey (2000). Modern Analytical Chemistry. Publisher: McGraw-Hill D. Keely and P. J. Haines (2002). Analytical Chemistry. Publisher: Oxford: Bios Scientific D. A. Skoog, D. M. West and F. J. Holler (1996). Fundamentals of Analytical Chemistry. Publisher: Saunders College Publication.

8. Minggu/ Week Kandungan Kursus / Course Contents (Panduan/ Guidelines ) Tugasan Bacaan/ Reading Assignment Pensyara h/ Lecture r Week 1 (9/09 – 13/09) INTRODUCTION TO ANALYTICAL CHEMISTRY Explain qualitative and quantitative. Repeat the steps in quantitative analysis or unit operation in analytical chemistry. Chapter 1 Dr. Saleha Week 2 – 3 (16/09 – 27/09) BASIC STATISTICS Define accuracy and precision, remember ways of describing accuracy and precision, types of errors, understand the concept of significant figures, standard deviation. UTILIZATION OF STATISTICS IN DATA ANALYSIS Identify the significant testing. Calculate the T test and Q test. CALIBRATION CURVE Interpret slope, intercept, coefficient correlation and coefficient of determination (r 2 ) Chapter 1 Dr. Saleha

9. Week 4 - 5 (30/9 – 11/10) CHEMICAL EQUILIBRIUM Discuss the concept of chemical reaction: the rate concept, type of equilibria, Le Chatelier’s principle. Effects of temperature, pressure and concentration on equilibria. ACID-BASE EQUILIBRIUM Repeat acids and bases theories, acid base equilibria in water, pH scale. Discuss weak acids and bases, calculate the pH of salt of weak acids and bases. Discuss buffers. Introduce strong acids and strong bases, Apply detection of end point, indicators. Discuss weak base versus strong acid. Chapter 2 Dr. Saleha Week 6 (14/10 - 18/10) Cuti Pertengahan Semester / Mid-semester Break Week 7 - 8 (21/10 – 1/11) PREPARING SAMPLES FOR ANALYSIS Discuss type of separation techniques. Classify separation techniques based on chemical or physical properties. Classify separation based on a partitioning between phases. Calculate partition coefficients and distribution ratios. Chapter 3 Dr. Saleha

10. Week 9-10 (4/11 – 15/11) CLASSICAL METHODS IN TECHNIQUES OF ANALYTICAL CHEMISTRY: TITRIMETRIC METHODS OF ANALYSIS Explain acid-base, redox, complexation and precipitation titrimetry. Discuss on the reactions involved. Calculate the quantitative and qualitative application of acid-base, redox, complexation, precipitation titrimetry. List other application titrimetry. Chapter 4 Assoc. Prof Dr. Mohamed Zulkali bin Mohamed Daud Week 11 – 13 (18/11 – 29/11) MODERN METHODS IN TECHNIQUES OF ANALYTICAL CHEMISTRY: CHROMATOGRAPHIC AND ELECTROPHORETIC METHODS Introduce principles of chromatography and electrophoresis. Discuss gas chromatography and applications. Calculate quantitative and qualitative applications of gas chromatography (GC). Discuss high- performance liquid chromatography (HPLC) and applications. Calculate quantitative and qualitative applications of high-performance liquid chromatography (HPLC). Discuss electrophoresis and its applications in protein and DNA analysis. Chapter 5 Assoc. Prof Dr. Mohamed Zulkali bin Mohamed Daud

11. Week 14 - 15 (2/12 – 13/12) MODERN METHODS IN TECHNIQUES OF ANALYTICAL CHEMISTRY: SPECTROSCOPIC TECHNIQUES Explain the properties of electromagnetic radiation and relate with spectroscopic techniques. Introduce techniques on spectroscopy based on absorption (ultraviolet-visible and Fourier transform- infrared spectroscopy (FT-IR) and atomic absorption spectroscopy (AAS). Demonstrate qualitative and quantitative applications of UV/visible, infrared and atomic absorption spectroscopic techniques in biological analysis. Calculate concentration using spectroscopic techniques. Chapter 6 Assoc. Prof Dr. Mohame d Zulkali bin Mohame d Daud Week 16 (16/12– 20/01) Minggu Ulangkaji / Revision Weeks Week 17 - 20 (23/12 – 10/01) Peperiksaan Akhir Semester/ Final Examination

12. LABORATORY PLAN Group A1, A2 & A3A4, A5 & A6B1, B2 & B3B4, B5 & B6 1 Introduction to Analytical Chemistry 2 Hari Malaysia 3 Exp 1Exp 5Tutorial 1 4 Exp 1Exp 5 5 Exp 1Tutorial 2 6 Mid Semester Break 7Tutorial 2Exp 5 Exp 1 8 Exp 4Tutorial 3 9 Exp 4 10 Exp 2Exp 3Tutorial 4 11 Tutorial 4Exp 2Exp 3 12 Exp 3Exp 2Tutorial 5 13 Tutorial 5Exp 3Exp 2 14 Tutorial 6 15 Lab Test 16 Study Week

13. A1B1 AINA MADIA BINTI RAZALI NUR HAZIRAH BINTI MOHD YUSOFF SITI NURSHAMILA BINTI ZAMZURY MOHAMAD AMIN BIN AWANG TEH @ ISMAIL LIM SHIN YUAN ANG LI WEI CHOO YEE CHING NUR AMALINA BINTI ABDULLAH SANI SITI KHADIJAH BINTI MASOR @ IBRAHIM KWAN SIN YEN ASSADUL HAQ ALI HAMIDI BOO CHIE HANG A2B2 MUHAMMAD FAIZ BIN ZAINOL BAHRI NUR AMIRAH BINTI MAHFOD SAW WAN LING NUR ASYILAH AKMAL BINTI ABDULLAH MOH LAI KUAN ANG KIAN THING NORHIDAYAH BINTI MOHAMAD NORHAIZA NADIA BINTI HALIB @ YAHAYA ONG LI JING MOHD SHAFIQ BIN MD ZIN ANNIEBELL A/P STANLEY LOURDES L.BENEDICT JASMINE FONG JIE MIN A3B3 NURUL NABILLATUL MUNIFA BINTI R. AZMI PUA CHEE WEE PUTRI NOOR NATASHA BINTI CHE YEO MEGAT NADYA ORSELA ANDICO CHUAH SIN YE ADZDZIN SHAFWAN BIN ADLAN SITI NABIHAH BINTI AB MAJID TAN HUAN YIH RAYMOND LIM HUNG TAT NUR ATHIRAH AWATIF BINTI ABDUL RAHMAN LAU KIA KIAN CHONG WAIN KET LAB GROUPS

14. A4B4 YUHANEES SYUHADAH BINTI MALIHAN NUR AMALINA BINTI MUHAMAD ZAIDI NUR AMIRAH ASIFA RAISHA BINTI ZAHARI NABILAH BINTI HUSAIN MOHAMAD ADIB BIN EDRIS CHEE CHEAU YEE WONG JING RUI NURUL NADIAH BINTI MOHAMAD NIZAM NUR SYAZWANI BINTI ISMAIL MUHAMMAD SYAFIQ BIN SANI LEONG YONG YOU CHEONG XIAN ZHI A5B5 VIVIAN LEE JIAQIAN ONG YU LIAN NURUL SHAKIRA BINTI JOHARI NOR SYAHIDA BINTI ISMAIL GOOI MING YAN SHARIFAH SABIRAH BINTI SYED HAMZAH TENGKU INTAN NADZRAH SITI AISYAH BINTI MOHD RAMLI NUR HIDAYU BINTI MISRAN NG ZHANG JIN MUHAMAD IKRAM BIN JAMALUDIN AMIRA NASYRAH BINTI MOHD HUSIN A6B6 SITI RABAAH BINTI HAMZAH TAN SIEW YEN NURAINI BINTI ABDULLAH NABILAH AFIQAH BINTI SUHAIMI MUN HUI SIN ONG XIN SHI NURULFARAHANA BINTI HARUN NOR ATIQAH BINTI JUSRIL NG PEY XUAN ANIS USMANI

15. Important Note: Your attendance to lecture / tutorial / laboratory is compulsory. If absent without reason, the student can not sit for the final examination.