1. April 13, 2003American Physiological Society Peer Review and Production Margaret Reich Director of Publications

2. April 13, 2003American Physiological Society Information for Authors http://www.the- aps.org/publications/journals/pub_ quick.htm http://www.the- aps.org/publications/journals/pub_ quick.htm http://www.the- aps.org/publications/apscentralguid e.pdf http://www.the- aps.org/publications/apscentralguid e.pdf

3. April 13, 2003American Physiological Society

4. April 13, 2003American Physiological Society

5. April 13, 2003American Physiological Society Online Submission and Peer Review APS Central www.apscentral.org Manuscripts are uploaded by Author Checked by APS staff Released to Editor in Chief

6. April 13, 2003American Physiological Society Online Peer Review, cont. Editor in Chief assigns Associate Editor Reviewers are invited by e-mail Reviews are uploaded to system Author notified of decision by e-mail Revision uploaded by Author Final Decision sent by e-mail

7. April 13, 2003American Physiological Society Using the System Read the Guide to Uploading Mss carefully Help is available via e-mail or phone Prepare ahead: – Save text and figs to one file – Prepare to pay $50 submission fee Form will be generated by the system after the submission process is completed

8. April 13, 2003American Physiological Society Your Paper is Accepted! Congratulations! (but youre not done yet) Read instructions in Acceptance Letter Upload manuscript file for immediate publication (AiPS) Send source files and hard copy for final publication

9. April 13, 2003American Physiological Society AiPS--Articles in PresS Manuscript published immediately PDF form of accepted manuscript Published, not a preprint Citable, using a DOI Indexed in PubMed, Medline

10. April 13, 2003American Physiological Society Publication Process for AiPS Choose to have your accepted ms published as an Article in PresS Upon acceptance, upload PDF of final version Check metadata Metadata verified by APS staff AiPS published within a week of us receiving everything from you

11. April 13, 2003American Physiological Society Publication Process, cont. Send source file, text, figures Important to follow Instructions to avoid delays CopyeditingNew Efficiencies Art EditingHelp for Authors

12. April 13, 2003American Physiological Society Copyediting Style Manual for Copy Editors APS Toolkit for copyediting – Automates coding – Automates changes to APS style – Automates rote editing, like reference lists

13. April 13, 2003American Physiological Society

14. April 13, 2003American Physiological Society «file»PG27-0_10e/mg «pg» «cpy»2000,$5.00 «art»MICROSATELLITE MARKER PANELS FOR MOUSE GENOTYPING «t»Microsatellite marker panels for use «f»in high-throughput genotyping of mouse crosses «a»OLGA A. IAKOUBOVA, 1 CHRISTINE L. OLSSON, 2 KATHERINE M. DAINS, 1 JIM CHOI, 1 IVETTA KALCHEVA, L. GORDON BENTLEY, MADALYNE CUNANAN, 2 DAVID HILLMAN, 1 JUDI LOUIE, 1 MIGDAD MACHRUS, 1 AND DAVID B. WEST 1 «aff» 1 Pfizer Global Research and Development Alameda Laboratories, Alameda 94502; and 2 Deltagen, Inc., Menlo Park, California 94025[1][1] «recd»3 May 2000,21 June 2000 «abs2»Iakoubova, Olga A., Christine L. Olsson, Katherine M. Dains, Jim Choi, Ivetta Kalcheva, L. Gordon Bentley, Madalyne Cunanan, David Hillman, Judi Louie, Migdad Machrus, and David B. West. «t»Microsatellite marker panels for use in high-throughput genotyping of mouse crosses. Physiol Genomics 3: ###--###, 2000.---Several microsatellite genotyping panel sets have been developed that are polymorphic between C57BL/6J and CAST/Ei mice, or C57BL/6J and DBA/2J. One set of markers for each strain pair has an intermarker distance of ~20 cM, and a second set has an intermarker distance of 5 cM. The 20-cM set contains 105 markers for C57BL/6J × DBA/2J and 108 for C57BL/6J × CAST/Ei, divided into 13 panels. Each 5-cM set includes 350 markers arranged into 45 panels. A panel contains a number of primer pairs whose fluorescently labeled PCR products can be pooled together and separated on one lane of a polyacrylamide gel. The sets are arranged by the size of the PCR product and by the type of fluorescent dye; 5-cM sets are also arranged by chromosomal region. The 20-cM sets are most useful for full-genome scans, the 5-cM sets are useful for full-genome and/or for region-specific chromosome screens. Both sets were proven as useful tools for speed congenic development, quantitative trait loci (QTL) analysis and physical mapping. These panel sets provide a throughput of 1,536-2,304 mouse genotypes daily per one gel-based system. Whole genome scans of one animal require 13 or 48 gel lanes, with 20 cM or 5 cM density, respectively. «key» C57BL/6J; CAST/Ei; DBA/2J; quantitative trait loci analyses; congenic mice «txt»microsatellite marker panels«r», that allow concurrent detection of multiple PCR products, are readily available and widely used for linkage studies in human molecular genetics [1][1] AU: Please send your corrections (galley pages, with query sheet, and enclosed original manuscript) to APS via an express delivery service (FAX is 301-571-1814; E-mail is mgoodwin@aps.faseb.org). Retain one copy of galleys, with your corrections, for your records.

15. April 13, 2003American Physiological Society Art Editing Challenges of working with digital art Need to streamline Looked for best practices, industry standard Accepted formats are EPS, TIFF, PowerPoint, and high-resolution PDF files Detailed instructions online

16. April 13, 2003American Physiological Society To Composition Copyedited ms and edited figures go to compositor Page proof (rapid-proof) is created E-mail is sent to author and copy editor for proofreading, so both can download pdf Author should print out proof, mark it up, and mail it back within 48 hrs Adobe 5.0 allows notes to be made on pdf

17. April 13, 2003American Physiological Society Proof Approved Article is paginated in an issue Final corrections are made Files go to printer Files go to HighWire for publishing online

18. April 13, 2003American Physiological Society Publication Online publication in journal issue Print publication mails ~ 2 weeks later Reprints mail ~ 4 weeks after issue mails Toll-free link to article

19. April 13, 2003American Physiological Society Article Versions Articles in PresS Final Journal issue published online Journal issue printed and mailed

20. April 13, 2003American Physiological Society Referencing the Versions Article in PresS DOIDigital Object Identifier Scarafia LE, Winter A, and Swinney DC. Quantitative expression analysis of the cellular specificity of HECT-domain ubiquitin E3 ligases. Physiol Genomics (April 26, 2001). 10.1152/physiolgenomics.00075.2001 Print Journal Scarafia LE, Winter A, and Swinney DC. Quantitative expression analysis of the cellular specificity of HECT-domain ubiquitin E3 ligases. Physiol Genomics 4: 147-153, 2001. First published April 26, 2001; 10.1152/physiolgenomics.00075.2001

21. April 13, 2003American Physiological Society Print vs. Electronic Libraries still need printarchiving What APS is doing about digital archiving All content free 12 months after publication APS members get all journals free online Digitizing APSs legacy data – To complete the historical scientific record – Back to 1898!

22. April 13, 2003American Physiological Society Open Access Experiment Physiological Genomics Author chooses – No author fees, subscription access for 1 year – Author pays $1500 per article, online access open immediately upon publications July 1, 2003

23. April 13, 2003American Physiological Society Contact Information Margaret Reich, Director of Publications, mreich@the-aps.org Gil Ebner, Peer Review Manager, gebner@the-aps.org Anna Trudgett, Editorial Manager, atrudget@the-aps.org Eric Pesanelli, Editorial Art Manager, epesanel@the-aps.org