1. 1 GL-1543a EDIT-long-road The Long Road to a New Medicine John H. (Wick) Johnson, Ph.D. Pfizer Global Research & Development Ann Arbor, Michigan

2. 2 GL-1543a EDIT-long-road The Long Road to a New Medicine Discovery Exploratory Development Full Development Registration

3. 3 GL-1543a EDIT-long-road The Long Road to a New Medicine Discovery Exploratory Development Registration Full Development Project Team and Plans Synthesis of Compounds Screening Early Safety Studies Candidate 3 GL-1543a Rev. 11/00

4. 4 GL-1543a EDIT-long-road The Long Road to a New Medicine Large Amounts of Candidate Medicine Synthesized Project Team and Plans Synthesis of Compounds Early Safety Studies Candidate Formulations Developed Extensive Safety Studies Studies in Healthy Volunteers Phase I Discovery Exploratory Development Full Development Registration Screening

5. 5 GL-1543a EDIT-long-road The Long Road to a New Medicine Discovery Exploratory Development Full Development Registration Large Amounts of Candidate Medicine Synthesized Project Team and Plans Synthesis of Compounds Early Safety Studies Candidate Formulations Developed Extensive Safety Studies Screening Studies in Healthy Volunteers Phase I Candidate Medicine Tested in 3-10,000 Patients (Phase III) Studies in 100-300 Patients (Phase II) Clinical Data Analysis 5 GL-1543a Rev. 11/00