1. By:Dawit Ayele MD,Internist

2.  Acute Pericarditis  Chronic Relapsing Pericarditis  Constrictive Pericarditis  Cardiac Tamponade

3.  Two major components ◦ serosa (viceral pericardium) mesothelial monolayer facilitate fluid and ion exchange ◦ fibrosa (parietal pericardium) fibrocollagenous tissue  Pericardial Fluid ◦ 15 - 50 ml of clear plasma ultrafiltrate  Ligamentous attachments ◦ to the sternum, vertebral column, diaphragm

4.  not needed to sustain life  physiologic functions ◦ limit cardiac dilatation ◦ maintain normal ventricular compliance ◦ reduce friction to cardiac movement ◦ barrier to inflammation ◦ limit cardiac displacement

5.  Contiguous spread ◦ lungs, pleura, mediastinal lymph nodes, myocardium, aorta, esophagus, liver  Hematogenous spread ◦ septicemia, toxins, neoplasm, metabolic  Lymphangetic spread  Traumatic or irradiation

6.  inflammation provokes a fibrinous exudate with or without serous effusion  the normal transparent and glistening pericardium is turned into a dull, opaque, and “sandy” sac  can cause pericardial scarring with adhesions and fibrosis

7.  Outpatient setting ◦ usually idiopathic ◦ probably due to viral infections *Coxsackie A and B (highly cardiotropic) are the most common viral cause of pericarditis and myocarditis *Others viruses: mumps, varicella-zoster, influenza, Epstein-Barr, HIV

8.  Inpatient setting T = Trauma, TUMOR U = Uremia M = Myocardial infarction (acute, post) Medications (hydralazine, procain) O = Other infections (bacterial, fungal, TB) R = Rheumatoid, autoimmune disorder Radiation

9.  History sudden onset of anterior chest pain that is pleuritic and substernal  Physical exam presence of two- or three-component rub  ECG most important laboratory clue

10.  Common characteristics ◦ retrosternal or precordial with raditaion to the neck, back, left shoulder or arm  Special characteristics (pericarditis) ◦ more likely to be *sharp and pleuritic ◦ with coughing, inspiration, swallowing ◦ worse by lying supine, relieved by sitting and leaning forward

11.  Pericardial friction rub is pathognomic for pericarditis  scratching or grating sound  Classically three components: ◦ presystolic rub during atrial filling ◦ ventricular systolic rub (loudest) ◦ ventricular diastolic rub (after A2P2)

12.  ST-segment elevation ◦ reflecting epicardial inflammation ◦ leads I, II, aVL, and V3-V6 ◦ lead aVR usually shows ST depression  ST concave upward ◦ ST in AMI concave downward like a “dome”  PR segment depression (early stage)  T-wave inversion ◦ occurs after the ST returns to baseline

16.  Treat underlying cause  Analgesic agents ◦ codeine 15-30 mg q 4-6 hr  Anti-inflmmatory agents ◦ ASA 648 mg q 3-4 hrs ◦ NSAID (indomethacin 25-50 mg qid) ◦ Corticosteroids are symptomatically effective, but preferably avoided

17.  occurs in a small % of patients with acute idiopathic pericarditis  steroid dependency requiring gradual tapering over 3-12 months; NSAIDs, analgesics, and colchicine may be beneficial  pericardiectomy for relief of symptoms is not always effective

18.  Described by Dressler in 1956  fever, pericarditis, pleuritis (typically with a low grade fever and a pericardial friction rub)  occurs in the first few days to several weeks following MI or heart surgery  incidence of 6-25%  treat with high-dose aspirin

19.  Acute myocardial infarction  Pulmonary embolism  Pneumonia  Aortic dissection

20.  rarely develop after an episode of acute idiopathic pericarditis  more likely to develop after subacute pericarditis with effusion that evolve over several weeks  more frequent after purulent bacterial or tuberculous pericarditis

21.  Idiopathic  radiotherapy  cardiac surgery  connective tissue disorders  dialysis  bacterial infection

22.  Incidence of pericarditis in patients with pulmonary TB ranged from 1-8%  Physical findings: fever, pericardial friction rub, hepatomegaly  TB skin test usually positive  Fluid smear for TB often negative  Pericardial biopsy more definitive

23.  Jugular veins ◦ prominent X and Y descent ◦ with inspiration (Kussmaul’s sign)  Lungs - possible pleural effusion  Heart - diastolic pericardial knock  Abdomen: ascites, pulsatile liver  Extremities: peripheral edema

24.  often not recognized in its early phases by exam, x-ray, ECG, echo  tendency to overlook elevated JVP subacute chronic diastolic knock +++ Kussmaul’s+++ paradoxical pulse++++

25.  serous ◦ transudative - heart failure  suppurative ◦ pyogenic infection with cellular debris and large number of leukocytes  hemorrhagic ◦ occurs with any type of pericarditis ◦ especially with infections and malignancies  serosanguinous

26.  Chest x-ray ◦ usually requires > 200 ml of fluid ◦ cannot distinguish between pericardial effusion and cardiomegly  Echocardiography ◦ standard for diagnosing pericardial effusion ◦ convenient, highly reliable, cost effective ◦ false positives (M-mode)- left pleural effusion, epicardial fat, tumor tissue, pericardial cysts

27.  asymptomatic unless they are large enough to compress adjacent organs ◦ dysphagia ◦ cough ◦ dyspnea ◦ hoarseness ◦ hiccups ◦ abdminal fullness ◦ nausea

28.  Diffuse low voltage ◦ amount of fluid ◦ electrical conductivity of the fluid  Electrical alternans ◦ alternating amplitude of the QRS ◦ produced by heart swinging motion ◦ also seen in PSVT, HTN, ischemia

29.  Decompensated cardiac compression from increased intracardaic press

30.  Early stage ◦ mild to moderate elevation of central venous pressure  Advanced stage ◦ intrapericardial pressure  ventricular filling,  stroke volume ◦ hypotension ◦ impaired organ perfusion

31.  Described in 1935 by thoracic surgeon Claude S. Beck  3 features of acute tamponade ◦ Decline in systemic arterial pressure ◦ Elevation in systemic venous pressure (e.g. distended neck vein) ◦ A small, quiet heart

32.  Elevated jugular venous pressure  Paradoxical pulse

33.  an exaggerated drop in blood pressure with inspiration (>10mmHg)  tamponade without pulsus ◦ atrial septal defect ◦ aortic insufficiency ◦ LVH with  LVEDP  pulsus without tamponade ◦ COPD, RV infarct, pulmonary embolism

34.  Pericardial effusion ◦ highly reliable  Cardiac tamponade ◦ RA and RV diastolic collapse ◦ reduced chamber size ◦ distension of the inferior vena cava ◦ exaggerated respiratory variation of the mitral and tricuspid valve flow velocities

35.  Diagnostic tap ◦ usually not indicated ◦ rarely have positive cytology or infection that can be diagnosed  Therapeutic drainage ◦ indicated for significant elevation of the central venous pressure

36.  Balloon dilatation of a needle pericardiostomy  subxyphoid surgical pericardiostomy  video-assisted thoracoscopy with localized pericardial resection  anterolateral thoracotomy with parietal pericardial resection