1. Cutaneous Membrane (Skin) - Superficial Epidermis (epithelial tissue) - Deeper Dermis (connective tissue) - Accessory Structures Hair and Hair Follicles Exocrine Glands Nails Integumentary System

2. The Integumentary System

3. 1) Physical Barrier from Environment 2) Regulation of Body Temperature (T b ) Functions of the Integumentary System 3) Secretions and Excretions 4) Vitamin D Synthesis 5) Sensations (receive sensory info) 6) Immunological Defense

4. Epidermis of Skin Dermis of Skin 7-dehydrocholesterol UV Light + Cholecalciferol (Vit D 3 ) Your cells only make Vitamin D if UV stimulation is adequate (~20 min/day) “Calcidiol” 25-Hydroxycholecalciferol (25-Hydroxy Vit D 3 ) Allow your healthy Liver to process Vit D 3 into Calcidiol. “Calcitriol” 1,25-Hydroxycholecalciferol (1,25-Hydroxy Vit D 3 ) ACTIVE FORM Allow your healthy Kidneys to process Calcidiol into the most active form, Calcitriol. UV Light UV Light The story of Vitamin D

6. Integument 1. Epidermis Membrane - Cutaneous 2. Dermis = 1. Stratified squamous - Protection - 4 or 5 layers 2. Areolar and Dense Irreg - Papillary – top 1/5 - Reticular – bottom 4/5 Accessory Structures 1.Hair and Follicles 2. Exocrine Glands - Sebaceous - Sweat (2 types) 3. Finger and Toe Nails

7. Epidermis = Stratified Squamous Epithelium. The thickness of the epidermis varies. Thin skin = ? Thick skin = ?

8. Keratinocytes Most abundant cell (80-90 % of cells in epidermis). Produces keratin, a hydrophobic lipoprotein, guards against water loss. Melanocytes Produce the dark pigment melanin. For protection against UV rays(10-20% of cells in epidermis). Merkel cells For nervous sensation in the epidermis (‘nerve endings’). Langerhans cells Defense cells in the epidermis; phagocytose substances. Cells of the Epidermis

9. Stratum Corneum: Most superficial layer, many layers of dead cells. Stratum Lucidum: Translucent layer, only in thick skin. Stratum Granulosum: Has dark staining granules. Stratum Spinosum: Can appear “spiny”. Stratum Basale or Germinativum: Division of basal cells, produces new keratinocytes (+ the other cells).

11. Role of Fingerprints?

12. Reticular Layer (Dense Irreg C.T.) – attaches skin to deeper tissues. – restrict spread of pathogens (defense). Papillary Layer (areolar C.T.) – nourishes and supports the epidermis. – sensory perception (touch, pressure, pain). – thermoregulation via blood vessels. The Dermis – many accessory structures located here.

13. The Dermis

14. Anatomy of a Tattoo

20. Typical Hair Growth Cycle

21. Hair Removal by Electrolysis

22. Roles - Stabilizes skin’s position. The Subcutaneous Layer Hypodermis Superficial Fascia - Permits limited independent movement. - Provides insulation and protection.

23. Skin Color 1. Melanin: amount = darkness. 2. Carotene: from diet. 3. Hemoglobin (Hb) + amount of blood: HbO 2 = red *If skin is thin, can see blood supply deep to it. Depends on 3 Things: Hb without O 2 = blue/purple Jaundice, Pallor, Cyanosis, Albinism, Erythemia, Hematoma

24. Accessory Structures of the Skin Roles: - Protection - Insulation 1. Hair and the Hair Follicle

25. Hair Color and Texture Determined by the amount of melanin in hair bulb. More Melanin – Darker Hair Less Melanin – Lighter Hair Air Bubbles in Medulla – White Hair! *If hair is Red, this is another iron (Fe) containing pigment, called trichosiderin. Hair Color:

26. Hair Root Cross Section (x.s.) Hair Longitudinal Section (l.s.)

27. Hair Color and Texture Determined by cross section of hair shaft. Round – Straight Hair. Oval – Curly Hair. Flat – Wavy or Kinky Hair. Hair Texture:

28. 2. Exocrine Glands - Sebaceous Glands secret sebum onto hairs. - Sebaceous Follicles are large sebaceous glands not associated with hair. Sebaceous (Oil) Glands

29. Sebaceous Glands

30. 2) Apocrine Sweat Glands Thicker, lipid rich secretion, only in specific regions of the body, e.g., axillary and inguinal regions. 1) Merocrine Sweat Glands Thin, watery, sensible perspiration, more numerous than apocrine, highest density on palms and soles. Sudoriferous (Sweat) Glands Mammary Glands Large, complex apocrine sweat glands, produce milk as nourishment for babies. Ceruminous Glands Produces waxy cerumen (ear wax), found in ear canal to keep eardrum protection and pliable. Modified Apocrine Sweat Glands

32. Sudoriferous (Sweat) Gland

33. 3. Finger and Toe Nails

34. Aging of the Integumentary

35. Burns and the Integument Tissue Damage 1 st Degree 2 nd Degree 3 rd Degree Tissue Appearance Recovery and Risks Epidermis is Damaged (or destroyed) Epidermis is Destroyed Epi & Dermis are both Destroyed Papillary of Dermis May be damaged Dermis is Damaged + assoc. structures Red in color Blister Charred, black or white in color Painful (tender) Painful 2-3 days 1-2 weeks 6 months Skin cancer from Repeated burn Typically don’t pop blister (infection) Deeper tissue Damage May not be painful - Infection - Dehydration Mild edema Edema

36. Lines of cleavage follow lines of tension in the skin.