1. New Approaches for Addressing Long Term Survivorship in Transplant Patients Dennis L. Confer, M.D. Chief Medical Officer National Marrow Donor Program May 16, 2015 Leukemia Research Foundation Treatment Options for Blood Cancer Patient Conference 1

2. A Little History 1968First successful related donor transplants 1973First successful unrelated donor transplant 1974Anthony Nolan Register established 1979Laura Graves URD transplant for ALL 1986NBMDR -> NMDP established 1987Two transplants completed Today:World’s largest registry >12.8 million donors >214,000 CBUs >70,000 Transplants completed NMDP has received 29 years of uninterrupted Federal support 2

3. Our Network Partners 3 We are the hub of a global transplant network including partner centers throughout the U.S. as well as centers and registries in 41 countries.

4. Total Growth of the Be The Match Registry ® Adult Donors Cord Blood Units 4

5. What about the likelihood of finding a donor? Recently published study in the New England Journal of Medicine NMDP/Be The Match collaborators Reviewed match rates for 21 unique ethnicities in the U.S. Gragert L, et al. N Engl J Med. 2014; 371(4): 339-348 5

8. Pasquini MC, Wang Z. Current use and outcome of hematopoietic stem cell transplantation: CIBMTR Summary Slides, 2013. Available at: http://www.cibmtr.orghttp://www.cibmtr.org

9. Transplants by Cell Source 9

10. Transplants by Recipient Age

11. Free support and resources 11 Confidential one-on-one support and guidance –Experienced team of Patient Services Coordinators can answer your questions, share resources and provide support –Peer Connect Program matches you with a patient or caregiver who can share their transplant experience Free resources to help you before, during and after transplant –Print, video and online resources –Many available translated in Spanish and 10 other languages –Order or download online at bethematch.org/request

12. After Transplant Guidelines 12 Easy-to-understand post- transplant check-up guidelines Recommended tests and evaluations for your follow-up appointments Available online or as a mobile app -BeTheMatch.org/patient-survive -Search “transplant” in the iTunes or Android store, then download

13. Living Now: A Guide to Life After Transplant Living Now is a collection of observations, tips, and resources delivered in newsletter format Each issue addresses various aspects of life after transplant, from 3 months post transplant, to 2 years and beyond To order: –BeTheMatch.org/request –Email: patientinfo@nmdp.org 13

14. Stay Connected Living Now e-newsletter and Facebook Living Now, a free e- newsletter designed for transplant patients and their families. To sign-up to receive Living Now –BeTheMatch.org/patient-enews Patients Connect Facebook 14

15. Connect with us Learn: BeTheMatch.org/patient Request Information: BeTheMatch.org/request Email: patientinfo@nmdp.orgpatientinfo@nmdp.org Call: 1 (888) 999-6743 15