1. Jonathan Simon Biology / Electrical & Computer Engineering University of Maryland, College Park Thanks to Luiz Pessoa for MNC slides

2.  NSF grant by NACS faculty 3 Tesla Siemens MRI machine

3.  Funds from the campus: $2-3 million Broad support across several colleges (BSOS, ENGR, CMNS, etc.)  Northeast of campus Across route 193 Off Metzerott road

4.  Multiple modalities for brain research MRI EEG: Electroencephalography (soon) MEG: Magnetoencephalography (~ 1 year) http://uuhsc.utah.edu/uumsi/images/sensor_array.jpg http://ling.umd.edu/assets/photos/2011/06/07/KIT_MEG_350x350.jpeg

5.  Basic studies of perception, cognition, and emotion  Clinically relevant research Autism, Dyslexia, Anxiety, Addiction, etc.  Work with adults and children Not yet with animals (only barrier is $$)

6.  Determine “activations” to task conditions http://t2.gstatic.com/images?q=tbn:ANd9GcTu4yd12HA97oU222KOoUrVELjAE5kVdhVS_71JOAYq2woSjJGr Region does X! e.g., V1 “does” orientation processing

7.  Ocular dominance columns Because of the connectivity from eye to cortex, eye-of-origin related columns exist in early visual cortex Horton

8.  Ocular dominance columns with fMRI In-plane resolution: 470 x 470 µm Column width: 1.1 mm session 1 session 2 SA Horton

9.  Machine learning to “decode” brain states What is the person seeing?

10.  Graph-theoretic analysis How are brain regions organized as a function of condition, population (autism vs. control), etc.?  Nodes: brain regions  Edges: “functional connectivity” between regions Correlation

11.  Reconstructing physical connection paths http://3.bp.blogspot.com/XaZAD5nhhH4/TVbUkY0aJjI/AAAAAAAAHis/dZXN82sE03o/s1600/ Fiber_Tractography.JPG http://www.epicareflorida.com/images/ Hippocampal_sclerosis.jpg

12.  Run the same experiment with functional MRI and MEG  Integrating the two modalities Spatial resolution of functional MRI Temporal resolution of MEG t = 32 mst = 38 msFrom Ou et al (2009)

13.  Introductory course in the Fall Upper level undergraduate Graduate  Intermediate/advanced course in Spring Graduate

14.  $600/hour  Seed funding available Faculty Students + Faculty Idea is that pilot data will be used for grant application to support research

15.  Meets every other Friday from noon-1 Focus on MRI, MEG, and EEG related work Open to all techniques that study the brain!

16.  Come visit sometime! http://www.thecnnh.org/ACEC/images/jimmysmile_phan.jpg