1. Small,...,Small World by Ralph C. Merkle Main Issues of Nanotechnology Molecular manufacturing system cosmetics. How to build such systems w/current technology. Devices Self-Replication – Assemblers Drexler robotic arm Stewart platform Diamond as a dream material Great Thermal Conductivity Large Band Gap Synthesis of Diamond Chemical Vapor Deposition Hydrogen abstraction tool Carbene insertion tool Hydrogen Deposition tool Future Work SPM: Needs to be faster. "Building block" based Nanotechnology. Critics / Time frame

2. The Once and Future Nanomachine What is a machine? Nanomachines already exist "electric motor/generator" bacterium RNA and protein - the ribosome Biological nanomachines and the self-replicating cell Strategy -first polymerization then spontaneously fold into function The cell is a Collection of Catalysts Can we make tiny replications of large machines Problems We don't know how? Where's the power? Storage and usage of information? Size of "Jaws" for assemblers Nature of atoms Evolution or scientific design? learn from biological examples genetic engineering?

3. Our Thoughts Merkle’s Small Small World Many theories –Positional Control –Diamonds Lot’s of real World examples/applications –Planes, Cars, Potatoes… –Medicine Critics/Time frame Whiteside’s Once and Future Nanomachines Practical and “realistic” –Nanomachines exist –Use biological examples to get ideas Problems –Size –Power –Sticking Evolution vs Nanotechnology Design –New Technologies