1. Research is Expensive

2. Research for the People The NIH invests over $31.2* billion annually in medical research for the American people.* More than 80% of the NIH's funding is awarded through almost 50,000 competitive grants to more than 325,000 researchers at over 3,000 universities, medical schools, and other research institutions in every state and around the world.competitive grants About 10% of the NIH's budget supports projects conducted by nearly 6,000 scientists in its own laboratories, most of which are on the NIH campus in Bethesda, Maryland.NIH campus in Bethesda, Maryland

3. http://www.nih.gov/about/budget.htm New Budget Budget history of each Institute from 1938 Funding levels for diseases Funded Organizations Success rates

5. Costs of common items ItemCost HPLC grade CH 3 CN, 4 x 4L$634.66 pH meter + electrode$1435.46 NMR tubes, suprasil, 500 MHz, 5 pk$70.41 Fluorescence cuvette, quartz, Teflon stopper, 2 pk $648.06 500 mL 3 neck RB, 24/40, 4 pk$97.47 1 mL blue pipette tips, non-st, 1000$44.60 Kimwipes, box of 280$2.11 95%, per residue $24.00 Edwards vacuum pump, oil sealed, direct drive$5469.00 Nd:YAG 2J @ 532 nm, pulsed ca. 5 ns, 10 Hz>$350K

7. LabX.com

8. Grant Budget

11. Animal Studies/ per diem

12. Grant Help A collection of expert advice to help with your grant and funding challenges Did you know that almost 80% of NIH grant applications don't get funded. Even worse, you have only two chances for the NIH reviewers to approve your grant proposal for funding. Getting grant money can truly be considered a war so you need to arm yourself with all the proper resources. History teaches us that the most significant battles were won due to the fact they were well planned, staged, and executed. We've spoken to hundreds of NIH grant reviewers, and almost all of them have told us that principal investigators must prepare themselves better when submitting proposals. Much like successful battles throughout history, victories were not based on hope, but rather on the significant time, effort, and resources that went into the strategic planning. > SNEAK PEEK: Table of Contents > SNEAK PEEK: Study Section Insider: 5 Mistakes That Will Sink Your Grant > Only $189 (List Price $378), Order Online or Call 1-800-303-0129SNEAK PEEK: Table of ContentsSNEAK PEEK: Study Section Insider: 5 Mistakes That Will Sink Your GrantOrder Online

13. 5 Mistakes http://principalinvestigators.org / 1. The reviewers did not find your central scientific question interesting. 2. The preliminary data are weak, and call into question the feasibility of the proposal and the validity of your central hypothesis. 3. The proverbial house of cards: the overall success of the grant is dependent on the outcome of a key experiment, which has yet to be performed. 4. The scope of the project is too ambitious, with multiple hypotheses or rationales that pull the grant in disparate directions. 5. The PI and or research team lacks the experience to carry out the proposed work.

17. Where to do Research Advantages Disadvantages Your Garage Industry Basic Science Medical Government Labs

18. Your Garage Advantages Disadvantages Independent No equipment Come and go No salary Any idea No guidance patent pay lawyers

19. Industry (pharma) Advantages Disadvantages Equipment Direction Salary Fired Money Sign work DiscussionTheir product

20. Basic Science Advantages Disadvantages Some equipment Teach Salarymeetings Some moneyTheir patent students (cheap) Own Problems Start up money patent

21. Medical Advantages Disadvantages Some equipment Little money MD’s Little salary Patients No workers Own ideas MD’s Own time no meetings

22. Government Labs Advantages Disadvantages EquipmentDirected SalaryBeholden to Congress Discussion Techs

23. Drug Companies Bioassay Concentrate compound of interest Determine structure Synthesize Derivatize or modify to maximize affect Animal studies Clinical studies 10 years $400-$800 million.

24. Natural Product Chemist Organic Chemist Isolate and identify active compounds in nature Chromatography Spectroscopy Synthesize