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Can secondary analysis teach us on best practice of universal QoL measurement Arguments and (some) Evidence Prof. Gouke J Bonsel MPH MD PhD Public Health.

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Presentation on theme: "Can secondary analysis teach us on best practice of universal QoL measurement Arguments and (some) Evidence Prof. Gouke J Bonsel MPH MD PhD Public Health."— Presentation transcript:

1 Can secondary analysis teach us on best practice of universal QoL measurement Arguments and (some) Evidence Prof. Gouke J Bonsel MPH MD PhD Public Health Methods Obstetrics Academic Medical Centre - University of Amsterdam Working Paper No.10 21 November 2005 STATISTICAL COMMISSION andSTATISTICAL OFFICE OF THE UN ECONOMIC COMMISSION FOREUROPEAN COMMUNITIES EUROPE (EUROSTAT) CONFERENCE OF EUROPEAN WORLD HEALTH STATISTICIANS ORGANIZATION (WHO) Joint UNECE/WHO/Eurostat Meeting on the Measurement of Health Status (Budapest, Hungary, 14-16 November 2005) Session 5 – Invited paper

2 051116 Budapest2 Agenda Comparative Secondary analysis: wanted? Goals of Measurement –Contents –Process C2A –Quantitative - Validity –Qualitative - Q/D Vignette –Quantitative - Coverage/Refinement general belief: many issues can be resolved by data

3 051116 Budapest3 Comparative secondary analysis (C2A) >2 crude datasets with –known questionnaire + codification rules –known population (at least vs. general) –sharing > 1 intended concept –sufficient common question/response types –sufficient language commonalities special cases –1 questionnaire, n populations –n questionnaires, > 1 populations

4 051116 Budapest4 Comparative secondary analysis : types quantitative, analytical content-driven methods; with and w/o external criterion quantitative, descriptive (technical) performance methods qualitative, semantics qualitative comparison response form, other operational features all head-to-head analysis will assume some aspects to be constant over the units to be compared

5 051116 Budapest5 Goals of QoL measurement CONTENTS Intrinsic goals of health systems WHO (+EU?) –Health (DALE-like; class) Level Distribution –Responsiveness Level Distribution –Fairness of financing Distribution Washington –Monitoring health population [Health Level] –Care provision [Responsiveness+ Level] –Equal pursuit [Health+Responsiveness Distribution] External goals (GJB) –Employment, autonomy, reproduction

6 051116 Budapest6 Goals of QoL measurement CONTENTS Health State measurement (per domain) –multi-item classical test Q (mQ): no –ordinal classification (class): yes –cf. ItemResponseTheory calibrated : perhaps Suitability for index development –in general : perhaps –to compose QALY/DALY estimates : yes (but do not tell) Projection from mission WHO; to existing instruments and accepted classifications

7 051116 Budapest7 Goals of QoL measurement PROCESS EfficientElaboration ReliableElaboration Universality of acceptance Flexibility of mode of administration Low price, low burden Fancy appearance

8 051116 Budapest8 Some remarks (1) Domains –normal is absence of dys[...]. avoid ‘better than normal’ discussion (concept: health is positive, item: happy instead of downhearted). think of playing music: there is no better than playing on the beat –from ALL external criteria, except ease of measurement and peace of mind follows about equal space for physical versus psychological domains; less (not absent) for social –projection WHO mission, WHO classifications, other instruments: ex post or ex ante –take care for conceptual unidimensionality artefact and the interpretation of empirical correlation as redundance classification nor IRT ‘require’ empirical independence

9 051116 Budapest9 Some remarks (2) Domains & Items & Time –(pattern over) time is an essential conceptual component, recall technicalities of minor consideration. –all concepts are continuous over time but some state changes appear as events or episodes or chronic states, or can only defined on (restricted) activity (=event) base hence frequency and intensity to some extent are semantic convention –consequences: time can emerge in pre-ambule, item, and response. uniformity over the questionnaire essential. people ignore pre-ambules empirical (pattern over) time therefore decides on ‘frequency’ or ‘intensity’, but on average both are relevant experience tells that virtually all domains have day-to-day fluctuations, if unstandardized response is during best condition graphical tools useful if unidmensional item, sofar academic

10 051116 Budapest10 Some remarks (3) Items / Response –burden of 3 domains * 6 responses smaller than 6 domains * 3 responses –distributional economy ignored; 2 levels is not best, subjective scale experience does not apply; filtering assumes errorless contextfree threshold judgment. Shannon’s methodology –equilizing in semantics across young/old, man/women, rich/poor, nationality or culture standardizes rather than exposes desired? differences –contextual aspects often ignored; also suitability for translation –reliability information (across time, observers, mode of administration) scarce

11 051116 Budapest11 C2A: Quantitative Head-to-head Validity With external criterion –domain specific consequences or etiology and personal chars with prespecified relation. strength of association (preferably RR) –examples psychological domain - use of specific care, suicide; preceding life events mobility domain - use of physiotherapy, aids; fracture preceding period cognitive domain - age

12 051116 Budapest12 C2A: Quantitative Head-to-head Validity Without external criterion –domain relations. prespecified patterns. strongly dependent on population (random if about healthy). comparison difficult if scale type differs (mQ, class, IRT) –special case if measure is contained as anchor –ex. psychological domains vs. physical domains all domains vs. HUI-Ambulation or EQ-Mobility

13 051116 Budapest13 C2A: Quantitative Head-to-head Validity Without internal cutpoint calibration information –Domainwise IRT analysis With internal cutpoint calibration information (vignettes) –Domainwise CHOPIT like analysis calibration: difficult but essential ALSO in countries

14 051116 Budapest14 C2A: Qualitative Head-to-head Suitability to compose vignettes (timeless states, annual profiles) to arrive at Q/D values –self-reflective domain terms –linguistic (non-numerical), objective response mode –clearcut time aspect –across domains ‘uniformity’ of terms, categories and time

15 051116 Budapest15 C2A: Quantitative Head-to-head Efficiency Source: investigations supporting increase of levels of EQ5D3L (‘HUI-fication’) No methods available to demonstrate benefit of more refinement Method: Shannon’s informativity measure = non-parametric (desirable) quantifier. Source US study http://www.ahrq.gov/rice/ and Med Care 2005;43:203-20&221-28

16 051116 Budapest16 C2A EXAMPLE EQ-5D, HUI2 and HUI3 dimensions with # levels and # unique permutations defined by full descriptive system. Common Dimensions are Grey

17 Level descriptions common domains EQ-5D, HUI2 & HUI3

18 051116 Budapest18 Absolute and % distribution of responses EQ-5D, HUI2 & HUI3 (N = 3691) From the number of potential categories and observed frequencies we can compute Shannon numbers The more equally distributed the more info the better reliability the better sensitivity

19 051116 Budapest19 H’ and J’ with skewed and rectangular distributions in 3 level vs. 5 level system Shannon numbers are cardinal

20 051116 Budapest20 H’ and J’ with skewed and rectangular distributions in 3 level vs. 5 level system If system extended but potential categories are not occupied then absolute Shannon H same relative Shannon J lower

21 051116 Budapest21 Shannon’s Absolute Index (H’) and Evenness Index (J’) for the Common Domains of EQ-5D, HUI2 & HUI3.

22 051116 Budapest22 Shannon’s Index (H’) and Evenness Index (J’) for EQ-5D, HUI2 and HUI3. Comparison by Instrument

23 051116 Budapest23 Conclusions C2A Efficiency by Shannon Head-to-head comparison tools allows choices on information gain by extension or recalibration Non-parametrically = advantage as independent from cutpoint (re)estimation In healthy or ambulatory diseased populations EQ5D3L equals HUI’s for common domains To be combined with differential cutpoint evaluation and reliability ! straightforwardly applicable for C2A to WHO/EU data if similar population or experimentation

24 051116 Budapest24 Reliability Systematic info to select item/respons –domain^respons * time (retest) –domain^respons * respondent (interobserver) –domain^respons * administration (retest) EQ5D: 3, 4 or 5 –experiment on representative panel under controlled conditions comparing 3L - 5L - RS –error, ‘filling the space’ and reliability

25 051116 Budapest25 The task: Classify/Rate ‘Self’ and Disease vignettes ? = Response = 3L, 5L, or horizontal unanchored VAS

26 051116 Budapest26 Projection model to reflect relations between 3L and 5L for 1 domain 8 short grey lines (g1.3, g1.4 etc.) represent inconsistent responses

27 051116 Budapest27 Inconstencies between 3L and 5L responses by dimension, all 15 health vignettes (N = 82) 3L to 5L no error increase

28 051116 Budapest28 Inter-observer reliability 3L vs 5L, 15 vignettes 5L much better !

29 051116 Budapest29 Test-retest reliability for respondents’ own health (3 wk interval) with ICC: 5L best !

30 051116 Budapest30 Frequency proportions 3L, 5L, and Rating Scale

31 051116 Budapest31 Aaverage 3Lrs, 5Lrs and RS mean values by dimension, all diseases and self-reported health. 3L and 5L values are transformed (linear) to RS scale range (0-100)

32 051116 Budapest32 Indirect and direct quantification of levels terms (n = 1230) Midway = 1/3 rate rule

33 051116 Budapest33 Shannon’s index (H’) and Shannon’s Evenness index (J’) values for 3L and 5L. Comparison by dimension

34 051116 Budapest34 Conclusions C2A Reliability of reponse terms Balance of 3 vs. 5 in favour of 5 (after WHO-choice) –error increase low –reliability better –Shannon rises (much) Fairly easy to investigate if great # of respondents C2A if multiple respons formats for 1 domain

35 051116 Budapest35 C2A of other process goals Universality of acceptance –quantitative and qualitative C2A depending on codes for non-respons Flexibility of mode of administration –qualitative comparison only Fancy appearance –qualitative comparison only Low price, low burden –quantitatively possible but who cares?

36 051116 Budapest36 Recommendations Comprehensive checklist for C2A –starting from structured agreed contents goals and process/technical goals –distinguishing between quantitative (incl Shannon) and qualitative research and what remains ! –specify models, techniques and success DATA can SOLVE debates INTERESTING CHOICES remain

37 051116 Budapest37 Appendix 1. A 5 level version of EQ-5D


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