1. RNS® Responsive Neurostimulation Epilepsy Treatment
Robert Thottam

2. Types of Epilepsy Partial or focal seizures Generalized seizures
Absence or petit mal seizures

3. Epilepsy
Partial or focal seizures: Only part of the brain is involved, so only part of the body is affected
Rhythmic or jerky movements
Strange sensations
Full feeling in the stomach
Small repetitive movements
Dazed or confused appearance

4. Current Treatments Ketogenic Diet Lesionectomy Prescription Medication
Tegretol or Carbatrol, Dilantin, and Depakote

5. Disadvantages
Allergies
Surgery Risks
Ineffective

6. RNS® Responsive Neurostimulation
RNS-300 Neuropace Inc.
Neurostimulator
Battery powered
Microprocessor
Internal and External Aspects

7. Internal Components
Implant
One or two wires
Electrodes

8. External Components Noninvasive Transcutaneous telemetry
Data Transmitter
Electrocortigrams (ECoG)

9. Process Abnormal brain activity Short Electrical Pulses
Frequency (1 to 333 Hz)
Current amplitude (0.5 to 12 mA),
Pulse width per phase (40 to 1000 µs)
Burst duration (10 to 5000 ms)
Recommended programming settings are 200 Hz, 160 µs, 100 ms
Data Transmission
30 seconds to 4 mins

10. Results Trial of 191 people Around 40% had lessening in seizures
No serious health issues reported
Neurological Devices Panel of the Medical Devices Advisory Committee Suggested FDA Approval

11. Limitations
Cost
Requires regular visits
Unknowns

12. Questions?

13. Work Cited
FDA Panel Endorses Epilepsy Device < >.
Clinical Trials < >.
Product Overview <
Whitesides GM. Results of a multicenter double blinded randomized controlled pivotal investigation of the RNS™ system for treatment of intractable partial epilepsy in adults. Abstract Presented at Annual Meeting of the American Epilepsy Society, December 2009
Epilepsy Health Center <
Abstracts Presented at the Annual Meeting of the American Epilepsy Society — December
Neural Prosthetics: Krishna Shenoy at TEDxStanford < 14>
RNS® SYSTEM FOR EPILEPSY < s/MedicalDevices/MedicalDevicesAdvisoryCommittee/NeurologicalDevicesPanel/U CM pdf>