1. Chapter 4 Carbon and the Molecular Diversity of Life 1

2. You Must Know The properties of carbon that make it so important. 2

3. Importance of Carbon Organic chemistry: branch of chemistry that specializes in study of carbon compounds Organic compounds: contain Carbon (& H) Major elements of life: CHONPS Carbon can form large, complex, and diverse molecules 3

4. Diversity of Carbon 1. It has 4 valence electrons (tetravalence) 2. It can form up to 4 covalent bonds  Most frequent bonding partners: H, O, N 4

5. 3. Bonds can be single, double, or triple covalent bonds. 5

6. 4. Carbon can form large molecules  4 classes of macromolecules: carbohydrates, proteins, lipids, nucleic ac ids 6

7. Diversity of Carbon 5. Molecules can be chains, ring-shaped, or branched 7

8. 6. Forms isomers Molecules have same molecular formula, but differ in atom arrangement different structures  different properties/functions Structural IsomerCis-Trans IsomerEnantiomers Varies in covalent arrangement Differ in spatial arrangement Mirror images of molecules 8

9. Isomers and Drug Manufacturing: Thalidomide = “good” enantiomer  reduce morning sickness “bad” enantiomer  cause birth defects “good” converts to “bad” in patient’s body Now used to treat cancers, leprosy, HIV 9

10. Fig. 4.8 The pharmacological importance of enantiomers 10

11. Functional Groups Behavior of organic molecules depends on functional groups Most common functional groups: Hydroxyl Carbonyl Carboxyl Amino Sulfhydryl Phosphate Methyl 11

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14. Functional Groups Functional Group Molecular Formula Names & Characteristics Example Hydroxyl-OHAlcoholsEthanol Carbonyl>CO Ketones (inside skeleton) Aldehydes (at end) Acetone Propanol Carboxyl-COOH Carboxylic acids (organic acids) Acetic acid Amino-NH 2 AminesGlycine Sulfhydryl-SHThiolsEthanethiol Phosphate-OPO 3 2- / -OPO 3 H 2 Organic phosphates Glycerol phosphate Methyl-CH 3 Methylated compounds5-methyl cytidine 14