1. Percutaneous Repair or Surgery for Mitral Regurgitation EVEREST II Objective:to compare the efficacy of percutaneous implantation of a clip and conventional surgery for repair or replacement of the mitral valve Study:multicenter randomized controlled trial (2:1 ratio) Population:patients with grade 3+ or 4+ mitral regurgitation Endpoint:efficacy: freedom from death, surgery for mitral dysf. at 12 months safety: composite of MACE within 30 days Objective:to compare the efficacy of percutaneous implantation of a clip and conventional surgery for repair or replacement of the mitral valve Study:multicenter randomized controlled trial (2:1 ratio) Population:patients with grade 3+ or 4+ mitral regurgitation Endpoint:efficacy: freedom from death, surgery for mitral dysf. at 12 months safety: composite of MACE within 30 days

2. Percutaneous Repair or Surgery for Mitral Regurgitation EVEREST II

4. Conclusion percutaneous repair is less effective than surgery for need of surgery for mitral dysfunction, but the safety was superior Conclusion percutaneous repair is less effective than surgery for need of surgery for mitral dysfunction, but the safety was superior Feldman NEJM 2011;364:1395-406