2. Store Manager with Acute Renal Failure Mrs. Calley, 35 yo, 5’3”, 125# Admitted post MVA in ER after car accident. Fractured leg, broken ribs, collapsed lung, and internal bleeding After surgery to stop internal bleeding, Mrs. Calley developed ARF (Acute Renal Failure)

3. Post Surgery:Urine Volume only 50 ml/day BUN = 75 mg/dl (10-20 mg/dl NL) Why did mrs. Calley develop arf? HYPOVOLEMIA; 2˚ TO MASSIVE BLOOD LOSS. OTHER KNOWN CAUSES OF ARF? HEART FAILURE, DRUG OVERDOSE, SEPSIS, TOXINS

4. MEETING MRS. CALLEY’S ENERGY NEEDS: CALCULATED NEEDS RANGE: 1989- 2809 KCAL/DAY HOW COULD WE ACCURATELY ASSESS THESE CALORIC NEEDS??????? INDIRECT CALORIMETRY: TO AVOID UNDER- OR OVERFEEDING UNDER- OR OVERFEEDING PROBLEM:URINARY OUTPUT LOW, NEEDS ARE HIGH. TOLERANCE LIKELY WILL BE LOW.

5. MONITOR BUN AND CREATININE TO DETERMINE IF DIALYSIS IS NEEDED. MONITOR SERUM POTASSIUM!! HYPERKALEMIA CAN CAUSE CARDIAC ARRHYTHMIAS!! WILL TOLERATE MORE PROTEIN, SODIUM, POTASSIUM

6. REMEMBER:EARLY PHASE OF ARF= OLIGURIC PHASE PROTEIN, SODIUM, POTASSIUM, AND FLUID ARE RESTRICTED. AS DIURESIS PHASE ENSUES, LARGE VOLUMES OF FLUID WILL BE LOST; BUN AND CREATININE WILL SLOWLY DECREASE. WATCH FOR HYPOKALEMIA.

7. Atherosclerosis Hypertension Nephritis Kidney Stones Renal Obstruction Diabetic Nephropathy Results from Irreversible Nephron Damage Gradual Decline in GFR Exhausts the “Renal Reserve” Symptoms Occur After ~75% Loss of Function!! HAPPENS OVER MONTHS TO YEARS!!!

8. DETERIORATION OF KIDNEY FUNCTION: GFR BUN SERUM CREATININE DECREASED ABILITY TO EXCRETE: UREA, CREATININE = UREMIC SYNDROME ACID (H IONS) = ACIDOSIS SODIUM = EDEMA POTASSIUM = HYPERKALEMIA (ARRHYTHMIAS)

9. RENAL FAILURE ASSOCIATED WITH: FLUID, SODIUM, POTASSIUM RETENTION HYPERLIPIDEMIA HYPERGLYCEMIA HTN CHF M.I. PULMONARY EDEMA ACCELERATED ATHEROSCLEROSIS

10. RENAL FAILURE ASSOCIATED WITH: RENAL OSTEODYSTROPHY GROWTH FAILURE AND WASTING SYNDROME ANEMIA

11. TREATMENT GOALS IN CHRONIC RENAL FAILURE: 1.DELAY PROGRESSION OF RENAL FAILURE. 2.PREVENT BUILD-UP OF TOXIC METABOLIC PRODUCTS AND THEIR COMPLICATIONS. 3.MAINTAIN NUTRITIONAL STATUS.

12. PHASE 1:CONSERVATIVE MANAGEMENT USING DIET AND PHARMACEUTICALS. DIET ALTERATIONS MAY INCLUDE PROTEIN, PHOSPHORUS, FLUID, SODIUM AND POTASSIUM RESTRICTIONS. PHASE 2:DIALYSIS PHASE SAME DIET CONCERNS PHASE 3:TRANSPLANTATION PHASE

13. sore throat Jason, 9 y0 boy, CO sore throat, tired, poor appetite stomach cramps, “bad” taste in mouth. Dx’ed with glomerulonephritis

14. In the following 3 years, Jason’s kidney fxn has declined. Current Labs:GFR:4 ml/min BUN:102 mg/dL Remember: CRF develops from ANY condition that progressively and permanently damages the kidneys.

15. Anthropometrics 4’ 3” 55# (45th %tile Height, 25th%tile weight) Current intake (by assessing usual intake): 30 g protein, 1100 kcal/day (44 kcal/ kg) Needed to support growth? ~80 kcal/kg ~2000 kcal/day Anorexia, Nausea contribute to poor intake low vitamin D production = poor growth Metabolic Bone Disease

16. Dialysis was instituted. What course of action would you recommend?? Effect on protein/ fluid intake levels? What if Jason receives a kidney transplant?

17. Serum Creatinine:produced at constant rate during muscle turnover direct indicator of muscle mass reflects renal excretion capability Not diet-related unless patient has high meat diet CreatinineClearance: Indicator of GFR and renal damage

18. Blood Urea Nitrogen: In healthy people, increases reflect excessive protein intake. Can increase in dehydration, traumatic injury, infections, etc. Uremic symptoms occur above 80 mg/dl Other measures: urine urea nitrogen (UUN)

19. Monitoring Phosphorus Levels: Restrictions can help stave off high serum phosphorus levels. Phosphate Binders (e.g., calcium carbonate, calcium acetate) are taken with meals to impede calcium absorption. New “gels” without calcium also accomplish this function. Avoid aluminum and magnesium-containing salts.

20. Use of Calcium Supplements Calcium absorption is impaired due to low renal 1-alpha hydroxylase activity. Poor control of serum calcium levels can cause some using Ca supplements to have hypercalcemia hypercalcemia. Supplemental vitamin D can help maintain blood calcium Levels (watch for hypercalcemia; ectopic calcification.

21. Other nutrient concerns: Iron-deficiency anemia: try erythropoietin. Zinc deficiency may cause dysgeusia and anorexia(altered taste perception)