1. You, Us and Dataseam Making a Difference in Kentucky A Big Difference December 8, 2009 Dr. James R. Ramsey President University of Louisville

2. You know the statistics… You may be a statistic… #1 Mortality Rate - 987 per 100,000 people - 842 is National Average #1 Cancer Death Rate - 237 per 100,000 people - 202 is National Avg. #4 Cardiovascular Death Rate #5 Heart Disease #12 Stroke

3. Our (UofL) Focus Public Agenda Specific Mandate World class cancer center

4. Our (All of Us) Challenge

5. But we cannot let the economy or the budget stop us or slow us down!

6. Partnerships can prove that 1+1>2 “Dataseam” A partnership between K-12, higher education and an entrepreneurial company (neat bunch of guys) A university sending its top scientists to school districts to talk about the importance of math and science Efficient use of resources, specifically using computer capacity in the schools to do cancer research

7. Partnerships can prove that 1+1>2 Creating new cancer drugs that have been licensed to a private company – Advanced Cancer Therapeutics – that is providing the capital to help move these drugs through clinical trials to the market Great legislative support Thank you Representative Rocky Adkins! Student financial aid for students throughout Kentucky

8. Partnerships can prove that 1+1>2 Students at S. Floyd High School developed a website for the researchers at the James Graham Brown Cancer Center This provided the students with an opportunity to be creative, set goals and to be “life long learners”.

9. Thank you!

10. Helping Kentucky; Helping the World UofL and James Graham Brown Cancer Center Three (3) drugs in early stage clinical trials Four (4) drugs in “late” preclinical development Twenty four (24) compounds in preclinical development

11. Helping Kentucky; Helping the World UofL and James Graham Brown Cancer Center More than $50 million invested since 1999 in building the drug development program More than $80 million in total Federal funding to support drug development research More than 50 scientists focused in the discovery and development of novel anti-cancer therapeutics

12. Tobacco Based HPV Vaccine

13. The Role of Bucks for Brains Research Support Higashi Arumugan Eaton Lane Fan Bates Li Trent Telang Mitchell Chesney Ghim Jenson Clark Ye Ratajczak Dean Palmer Cunningham Chaires Reca Ratajczak Kucia Lu Davis Sankar Lillard Sun Singh Miller Wattenberg Bodduluri Jala Gupta Ravoori Stansbury Kidd Hein Parrish Baumgartner R. Baumgartner K. Hollifield McGregor States Zacharias Zundel Rodu Ng Kakar Ng Martin Yan Goldstein 10 Bucks for Brains Chairs 55 New Faculty $26,925,760 Research Support in 2007

14. We are expected to help improve economic opportunity and quality of life for Kentuckians (HB1 – 1997). 14 How does this tie in to UofL’s mission?

15. Thank you! This would not be possible without people like you. Happy Holidays! 15