1. THE REGISTRY OF THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION: TWENTY-FIFTH ANNUAL REPORT ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

2. MAJOR CONTRIBUTORS TO THE ISHLT TRANSPLANT REGISTRY Australia and New Zealand Cardiothoracic Organ Transplant Registry (ANZCOTR): Australia Eurotransplant (ET): AustriaGermanySlovenia BelgiumNetherlands Scandiatransplant: DenmarkNorway FinlandSweden United Kingdom Transplant Services Authority (UKTSSA): United KingdomIreland United Network for Organ Sharing (UNOS): United States In addition, 85 individual centers from North America, Central/South America, Europe, Asia, and the Middle East have reported at least one transplant since 1995. ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

3. ACKNOWLEDGMENTS: We wish to extend our sincere thanks to the many thoracic transplant surgeons, physicians and data coordinators in transplant programs throughout the world whose timely and accurate submission of data has made these analyses possible. ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

4. REGISTRY STEERING COMMITTEE Marshall Hertz – Medical Director Jason Christie – Associate Dir. for Lung Transplantation David O. Taylor – Associate Dir. for Heart Transplantation Richard Kirk – Associate Dir. for Pediatric Heart Transplantation Paul Aurora – Associate Dir. for Pediatric Lung Transplantation Axel Rahmel – Associate Dir. for OEO and Transplant Center Relations Fabienne Dobbels - Associate Dir. for Outcomes Analysis Amanda Rowe – ISHLT Executive Director Leah Edwards – Associate Dir. for Data Analysis ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

5. General Registry Statistics ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

6. REGISTRY DATABASE: Number of Transplants Reported ORGAN Transplants Reported from 7/1/2006 through 6/30/2007 Total Transplants Reported through 6/30/2007 Heart3,11480,106 Heart-Lung633,341 Lung2,09925,950 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

7. REGISTRY DATABASE: Number of Centers Reporting Transplants Organ Centers Ever Reporting Data Centers Reporting Transplants in 1996 Centers Reporting Transplants between 1/2006 and 6/2007 Heart354243204 Heart-Lung1445138 Lung212129108 ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

8. REGISTRY DATABASE: Number of Centers Reporting Heart Transplants ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

9. REGISTRY DATABASE: Number of Centers Reporting Lung Transplants ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

10. REGISTRY DATABASE: Number of Centers Reporting Heart-Lung Transplants ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

11. APPENDIX ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

12. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT ARGENTINA Fundacion Favaloro x Hospital Italiano x AUSTRALIA 1 St. Vincent x Royal Children x The Prince Charles Hospital x The Alfred Hospital x Royal Perth Hospital x AUSTRIA 2 Allgemeines Krankenhaus Wien x Universitätsklinik Innsbruck x Landeskrankenhaus Graz x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

13. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT BELGIUM 2 Hôpital Erasme Bruxelles x Universitair Ziekenhuis Antwerpen x Onze Lieve Vrouw Ziekenhuis Aalst x Universitair Ziekenhuis Gent x Centre Hospitalier Universitaire Liège x Cliniques Universitaires, Université Catholique de Louvain x UZ Gasthuisberg Leuven x BRAZIL Heart Institute-Univ. Sao Paulo Hospital das Clinicas x Hospital de Messejana x CANADA Royal Victoria Hospital x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

14. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT CANADA (contd) Montreal Heart Institute x The Toronto General Hospital x Hospital Notre-Dame x Quebec Heart Institute - Laval Hospital x Ottawa Heart Institute x Health Sciences Centre x University of Alberta Hospitals/Walter C. Mackenzie Health Sciences x The Hospital For Sick Children x CHILE Hospital Gustavo Fricke x COLOMBIA Cliniica Cardiovascular x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

15. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT DENMARK 3 Skejby University Hospital x FINLAND 3 Helsinki University Central Hospital x Children's Hospital, Univ. of Helsinki x GERMANY 2 Universität des Saarlandes Homburg/Saar x Martin-Luther-Universität Halle x Herzzentrum Dresden GmbH x Deutsches Herzzentrum Berlin x Universität Leipzig - Herzzentrum x Klinikum der Universität Regensburg x Herzzentrum Nordrhein-Westfalen Bad Oeynhausen x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

16. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT GERMANY 2 (contd) Universitätsklinikum Essen x Universitätsklinikum Münster x Ruprecht-Karls-Universität Heidelberg x Medizinische Hochschule Hannover x Universitätsklinikum Aachen x Klinikum Fulda x Klinikum der Justus-Liebig-Universität Giessen x Universitätsklinikum Schleswig-Holstein Kiel x Johann Wolfgang Goethe Universität Frankfurt/Main x Friedrich Schiller Universität Jena x Friedrich Alexander Universität Erlangen x Ludwig Maximilians Universität München x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

17. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT GERMANY 2 (contd) Deutsches Herzzentrum München x Universitätsklinikum Hamburg x Klinikum der Albert-Ludwigs-Universität Freiburg im Breisgau x GREECE Onassis Cardiac Surgery Center x IRELAND 4 Mater Hospital x ISRAEL Rabin Medical Center (Belinson Campus) x Sheba Medical Center x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

18. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT ITALY Niguarda CA Granda Hospital x Policlinico S. Orsola - Universita degli Studi x JAPAN Tohoku University Hospital x Kyoto University Hospital x Saitama Medical School Hospital x KOREA Yongdong Severance Hospital x NETHERLANDS 2 Universitair Medisch Centrum Utrecht x Erasmus Medisch Centrum Rotterdam x Universitair Medisch Centrum Groningen x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

19. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT NEW ZEALAND Green Lane Hospital x NORWAY 3 Rikshospitalet - National Hospital of Norway x SPAIN Hospital Clinic x Hospital Central DE Asturias x SWEDEN 3 Sahlgrenska University Hospital x University Hospital of Lund x TAIWAN Cheng-Hsin General Hospital x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

20. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT UNITED KINGDOM 4 Great Ormand Street Hospital for Children x University of Glasgow/Glasgow Royal Infirmary x The Freeman Hospital x Harefield Hosp x Wythenshawe Hospital x Queen Elizabeth Hospital x Papworth Hospital x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

21. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT UNITED STATES 5 Univ. of Alabama Hospital, Birmingham, AL x Baptist Medical Center, Little Rock, AR x Arkansas Childrens Hospital, Little Rock, AR x The Univ. Hosp of Arkansas, Little Rock, AR x Mayo Clinic Hospital, Phoenix, AZ x St Josephs Hosp and Med Ctr, Phoenix, AZ x University Medical Ctr, Univ. of AZ, Tucson, AZ x Childrens Hospital Los Angeles, Los Angeles, CA x Cedars-Sinai Med Center, Los Angeles, CA x Loma Linda Univ. Med Ctr, Loma Linda, CA x California Pacific Med Ctr, San Francisco, CA x UCSD Medical Center, San Diego, CA x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

22. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT UNITED STATES 5 (contd) Univ. of CA San Francisco Med Ctr, San Francisco, CA x Sutter Memorial Hospital, Sacramento, CA x Sharp Memorial Hospital, San Diego, CA x Stanford Univ. Med Ctr, Stanford, CA x St. Vincent Medical Center, Los Angeles, CA x UCLA Medical Center, Los Angeles, CA x USC University Hospital, Los Angeles, CA x The Children's Hospital, Aurora, CO x University of Colorado Hospital/HSC, Aurora, CO x Hartford Hospital, Hartford, CT x Yale New Haven Hosp, New Haven, CT x Children's Natl Medical Ctr, Washington, DC x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

23. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006-6/2007 and Reported to ISHLT UNITED STATES 5 (contd) Washington Hospital Center, Washington, DC x Alfred I duPont Hospital for Children, Wilmington, DE x All Childrens Hospital, St. Petersburg, FL x Jackson Memorial Hosp, Miami, FL x St. Luke's Hospital, Jacksonville, FL x Tampa General Hospital, Tampa, FL x Shands Hosp at Univ. of FL, Gainesville, FL x Children's Healthcare of Atlanta, Atlanta, GA x Emory Univ. Hospital, Atlanta, GA x St. Joseph's Hosp of Atlanta, Atlanta, GA x Hawaii Medical Center – East, Honolulu, HI x Univ. of Iowa Hosp and Clinics, Iowa City, IA x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

24. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006-6/2007 and Reported to ISHLT UNITED STATES 5 (contd) Children's Memorial Hospital, Chicago, IL x Loyola Univ. Med Center, Maywood, IL x Northwestern Memorial Hospital, Chicago, IL x Rush University Med Ctr, Chicago, IL x OSF St Francis Med Ctr, Peoria, IL x Univ. of Chicago Med Ctr, Chicago, IL x Clarian Health-Methodist/IU/Riley, Indianapolis, IN x Lutheran Hosp of Ft Wayne, Ft Wayne, IN x St Vincent Hosp and Health Care Ctr, Indianapolis, IN x Via Christi Reg Med Center, Wichita, KS x Jewish Hospital, Louisville, KY x Kosair Childrens Hosp, Louisville, KY x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

25. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT UNITED STATES 5 (contd) Univ. of Kentucky Med Ctr, Lexington, KY x Ochsner Foundation Hospital, New Orleans, LA x Tulane Univ. Medical Center, New Orleans, LA x Children's Hospital Boston, Boston, MA x Massachusetts General Hospital, Boston, MA x Tufts Medical Center, Boston, MA x Brigham and Womens Hosp, Boston, MA x Johns Hopkins Hospital, Baltimore, MD x Univ. of Maryland Med System, Baltimore, MD x Children's Hosp of Michigan, Detroit, MI x Henry Ford Hospital, Detroit, MI x Univ. of Michigan Med Ctr, Ann Arbor, MI x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

26. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT UNITED STATES 5 (contd) Abbott Northwestern Hospital, Minneapolis, MN x St Marys Hospital (Mayo Clinic), Rochester, MN x Univ. of Minnesota Medical Center, Minneapolis, MN x Barnes-Jewish Hospital, St. Louis, MO x Cardinal Glennon Childrens Hosp, St. Louis, MO x St. Louis Children's Hospital, St Louis, MO x St Lukes Hosp of Kansas City, Kansas City, MO x St. Louis University Hospital, St Louis, MO x Univ. of MS Med Ctr, Jackson, MS x NC Baptist Hospital, Winston Salem, NC x Carolinas Med Ctr, Charlotte, NC x Duke University Medical Center, Durham, NC x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

27. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT UNITED STATES 5 (contd) UNC Hospitals, Chapel Hill, NC x BryanLGH Medical Center East, Lincoln, NE x The Nebraska Medical Center, Omaha, NE x Newark Beth Israel Med Ctr, Newark, NJ x Robert Wood Johnson University Hosp, New Brunswick, NJ x Albany Med Center Hospital, Albany, NY x The Presbyterian Hosp in NY City, New York, NY x Strong Memorial Hospital, Rochester, NY x Montefiore Medical Center, Bronx, NY x Mount Sinai Med Center, New York, NY x Westchester Medical Center, Valhalla, NY x Cleveland Clinic Foundation, Cleveland, OH x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

28. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT UNITED STATES 5 (contd) Nationwide Children's Hospital, Columbus, OH x Children's Hosp Med Ctr, Cincinnati, OH x Ohio State Univ. Med Ctr, Columbus, OH x Univ. of Cincinnati Medical Center, Cincinnati, OH x Providence Portland Medical Center, Portland, OR x Oregon Health and Science University, Portland, OR x Allegheny General Hosp, Pittsburgh, PA x Children's Hospital of Pittsburgh, Pittsburgh, PA x Childrens Hosp of Philadelphia, Philadelphia, PA x Penn State Milton S Hershey Med Ctr, Hershey, PA x Hahnemann University Hospital, Philadelphia, PA x The Lankenau Hospital, Wynnewood, PA x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

29. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT UNITED STATES 5 (contd) Univ. of Pittsburgh Med Ctr, Pittsburgh, PA x Thomas Jefferson Univ. Hosp, Philadelphia, PA x Temple Univ. Hospital, Philadelphia, PA x The Hosp of the Univ. of PA, Philadelphia, PA x Baptist Memorial Hosp, Memphis, TN x St. Thomas Hospital, Nashville, TN x Vanderbilt Univ. Med Ctr, Nashville, TN x University Hospital, San Antonio, TX x Children's Med Ctr of Dallas, Dallas, TX x Seton Medical Center, Austin, TX x Medical City Dallas Hospital, Dallas, TX x St Luke's Episcopal Hospital, Houston, TX x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

30. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2005-6/2005 and Reported to ISHLT UNITED STATES 5 (contd) Methodist Specialty & Transplant Hosp, San Antonio, TX x Univ. of Texas Med Branch, Galveston, TX x The Methodist Hospital, Houston, TX x Christus Santa Rosa Medical Center, San Antonio, TX x Cardiovascular Ctr of PR, San Juan, PR x University Hosp of Cleveland, Cleveland, OH x Integris Baptist Med Ctr, Oklahoma City, OK x Saint Francis Hospital, Tulsa, OK x Medical Univ. of SC, Charleston, SC x University Hospital - St. Paul, Dallas, TX x Texas Children's Hospital, Houston, TX x Baylor University Medical Center, Dallas, TX x (Contd) ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

31. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT UNITED STATES 5 (contd) Intermountain Medical Center, Murray, UT x Univ. of Utah Medical Center, Salt Lake City, UT x Primary Childrens Med Ctr, Salt Lake City, UT x Inova Fairfax Hosp, Falls Church, VA x Henrico Doctors' Hospital, Richmond, VA x MCV Hospitals, Richmond, VA x McGuire VA Medical Center, Richmond, VA x Sentara Norfolk General Hospital, Norfolk, VA x Univ. of Virginia HSC, Charlottesville, VA x Children's Hosp & Reg Medical Center, Seattle, WA x Sacred Heart Med Ctr, Spokane, WA x Univ. of Washington Med Ctr, Seattle, WA x ISHLT 2008 J Heart Lung Transplant 2008;27: 937-983

32. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed 1/2006- 6/2007 and Reported to ISHLT UNITED STATES 5 (contd) Childrens Hosp of Wisconsin, Milwaukee, WI x Froedtert Mem Lutheran Hosp, Milwaukee, WI x Aurora St. Luke's Medical Center, Milwaukee, WI x Univ. of Wisconsin Hosp and Clinics, Madison, WI x ISHLT 2008 1 Data provided via Australia and New Zealand Cardiothoracic Transplant Registry (ANZCOTR) 2 Data provided via Eurotransplant 3 Data provided via Scandiatransplant 4 Data provided via United Kingdom Transplant Support Service Authority (UKTSSA) 5 Data provided via United Network for Organ Sharing (UNOS) J Heart Lung Transplant 2008;27: 937-983