1. J Heart Lung Transplant 2009;28: 989-1049 LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2009

2. J Heart Lung Transplant 2009;28: 989-1049 RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG RECIPIENTS - NUMBER (Transplants: January 1986 - June 2008) ISHLT Analysis includes living donor transplants 2009

3. J Heart Lung Transplant 2009;28: 989-1049 RECIPIENT AGE DISTRIBUTION FOR PEDIATRIC LUNG RECIPIENTS - PERCENTAGE (Transplants: January 1986 - June 2008) ISHLT Analysis includes living donor transplants 2009

4. J Heart Lung Transplant 2009;28: 989-1049 DONOR TYPE DISTRIBUTION BY YEAR OF TRANSPLANT FOR PEDIATRIC LUNG RECIPIENTS (Transplants: 1986-2007) ISHLT NOTE: This figure includes only the lung transplants that are reported to the ISHLT Transplant Registry. As such, the presented data may not mirror the changes in the number of lung transplants performed worldwide. Analysis includes living donor transplants 2009

5. J Heart Lung Transplant 2009;28: 989-1049 DONOR TYPE DISTRIBUTION BY RECIPIENT AGE GROUP WITHIN ERA FOR PEDIATRIC LUNG RECIPIENTS (Transplants: January 1986 - June 2008) ISHLT Analysis includes living donor transplants 2009

6. J Heart Lung Transplant 2009;28: 989-1049 AGE DISTRIBUTION FOR DONORS OF PEDIATRIC LUNG RECIPIENTS (Transplants: January 1986 - June 2008) ISHLT 2009

7. J Heart Lung Transplant 2009;28: 989-1049 AGE DISTRIBUTION OF PEDIATRIC LUNG RECIPIENTS By Year of Transplant ISHLT Analysis includes living donor transplants 2009 NOTE: This figure includes only the pediatric lung transplants that are reported to the ISHLT Transplant Registry. Therefore, these numbers should not be interpreted as the rate of change in pediatric lung procedures performed worldwide.

8. J Heart Lung Transplant 2009;28: 989-1049 NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS ISHLT Analysis includes living donor transplants 2009

9. J Heart Lung Transplant 2009;28: 989-1049 NUMBER OF CENTERS REPORTING PEDIATRIC LUNG TRANSPLANTS BY CENTER VOLUME ISHLT Analysis includes living donor transplants 2009

10. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTATION: Indications (Transplants: January 1990 – June 2008) DIAGNOSIS AGE: < 1 Year AGE: 1-5 Years AGE: 6-11 Years AGE: 12-17 Years Cystic Fibrosis 22.4%55.1%12453.0%54769.2% Idiopathic Pulmonary Arterial Hypertension 1113.4%2222.2%2510.7%607.6% Re-Transplant: Obliterative Bronchiolitis 66.1%83.4%253.2% Congenital Heart Disease 2125.6%88.1%41.7%101.3% Idiopathic Pulmonary Fibrosis 44.9%88.1%104.3%263.3% Obliterative Bronchiolitis (Not Re-TX) 99.1%104.3%293.7% Re-Transplant: Not OB 33.7%22.0%73.0%182.3% Interstitial Pneumonitis 67.3%1111.1%10.4%50.6% Pulmonary Vascular Disease 89.8%55.1%73.0%10.2% Eisenmengers Syndrome 11.2%55.1%52.1%60.8% Pulmonary Fibrosis, Other 11.2%11.0%73.0%111.4% Surfactant Protein B Deficiency 1113.4%44.0% COPD/Emphysema 56.1%22.0%20.9%60.8% Bronchopulmonary Dysplasia 22.4%22.0%62.6% Bronchiectasis 41.7%91.1% Other 78.5%99.1%146.0%394.9% ISHLT Analysis includes living donor transplants 2009

11. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTATION: Other Indications (Transplants: January 1990 – June 2006) DIAGNOSIS AGE: < 1 Year AGE: 1-5 Years AGE: 6-11 Years AGE: 12-17 Years Alpha - 1 - Antitrypsin Deficiency1 0.2% ARDS/Pneumonia1 1.2%10.5% BOOP1 0.2% Dilated Myopathy: Adriamycin1 0.2% Graft-Vs-Host Disease (GVHD)1 1.2% 2 0.3% Idiopathic Pulmonary Hemosiderosis2 0.3% Inhalation Burns/Trauma1 0.2% Portopulmonary Hypertension1 1.2% Pulmonary Veno-Occlusive Disease1 0.2% Restrictive Lung Disease1 1.2% Rheumatoid Disease1 1.2% Scleroderma1 0.2% Secondary Pulmonary Hypertension 23.2% Other Lung Disease4 0.6% ISHLT Last updated based on data as of December 2006 Analysis includes living donor transplants 2009

12. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTATION: Other Indications (Transplants: January 1990 – June 2006) DIAGNOSIS (continued) AGE: < 1 Year AGE: 1-5 Years AGE: 6-11 Years AGE: 12-17 Years Other – Specify: 34.8% 2 2.5%21.0% 3 0.5% Chronic Interstitial Pneumonia1 Chronic Lung Disease Unknown Etiology 1 Diaphragmatic Hernia 1 End Stage Interstitial Lung Disease1 Pulmonary1 Pulmonary Interstitial Emphysema 1 Respiratory Failure 1 TALC/Pneumoconiosis/Berylliososis1 Unknown 11 ISHLT Last updated based on data as of December 2006 Analysis includes living donor transplants 2009

13. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTATION: Other Indications (Transplants: January 1990 – June 2006) DIAGNOSIS (continued) AGE: < 1 Year AGE: 1-5 Years AGE: 6-11 Years AGE: 12-17 Years Lung Disease: Other Specify 21.0% 3 0.5% Miscellaneous Lung: Not Specified2 Pulmonary Lymphangectasia 1 Not Reported 1 1 Other 10.5% 6 0.9% Congenital Anomaly1 Langerhans -Histiocytosis1 Not Reported 1 4 ISHLT Last updated based on data as of December 2006 Analysis includes living donor transplants 2009

14. J Heart Lung Transplant 2009;28: 989-1049 DIAGNOSIS IN PEDIATRIC LUNG RECIPIENTS BY YEAR OF TRANSPLANT Age: 12-17 Years ISHLT Analysis includes living donor transplants 2009

15. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTS: AGE DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2008 ISHLT Analysis includes living donor transplants 2009

16. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTS: DIAGNOSIS DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2008 ISHLT NOTE: Unknown diagnoses were excluded from this tabulation. Total number of transplants reported: Europe = 171 North America = 443 Other = 35 Analysis includes living donor transplants 2009

17. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTS: DONOR AGE DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2008 ISHLT NOTE: Transplants with unknown donor age and living donor transplants were excluded from this tabulation. Total number of transplants reported: Europe = 181 North America = 443 Other = 35 2009

18. J Heart Lung Transplant 2009;28: 989-1049 LUNG TRANSPLANTATION Kaplan-Meier Survival by Age Group (Transplants: January 1990 - June 2007) ISHLT 2009

19. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Procedure Type (Transplants: January 1990 - June 2007) ISHLT 2009

20. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival for Congenital Diagnoses (Transplants: January 1990 – June 2007) ISHLT 2009

21. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Age Group (Transplants: January 1990 - June 2007) ISHLT 2009

22. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTATION Conditional Kaplan-Meier Survival by Age Group (Transplants: January 1990 - June 2007) ISHLT 2009

23. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: January 1988 - June 2007) ISHLT 2009

24. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival by Donor Type for Recipients Age 12-17 Years (Transplants: January 1990 - June 2007) ISHLT 2009

25. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG RE-TRANSPLANTS Between January 1994 and June 2008 ISHLT Time Between Previous and Current Transplant 2009

26. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG RETRANSPLANTS Survival for Transplants Performed Between January 1994 and June 2007 ISHLT 2009

27. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG RECIPIENTS Functional Status of Surviving Recipients (Follow-ups: April 1994-June 2008) ISHLT 2009

28. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG RECIPIENTS Functional Status of Surviving Recipients For the Same Patients (Follow-ups: April 1994-June 2008) ISHLT 2009

29. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant of Surviving Recipients (Follow-ups: April 1994 - June 2008) ISHLT 2009

30. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG RECIPIENTS Rehospitalization Post-transplant of Surviving Recipients (Follow-ups: April 1994 - June 2008) ISHLT 2009

31. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression For transplants between January 2001 and June 2008 ISHLT Analysis is limited to patients who were alive at the time of the follow-up 2009

32. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG RECIPIENTS Induction Immunosuppression (Transplants: January 2001 - June 2007) ISHLT Analysis is limited to patients who were alive at the time of the follow-up 2009

33. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANTATION Kaplan-Meier Survival Stratified by Induction Use (Transplants: January 2001 - June 2007) ISHLT 2009

34. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up (F ollow-ups: January 2001 – June 2008) NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT Analysis is limited to patients who were alive at the time of the follow-up 2009

35. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up (Follow-ups: January 2001 – June 2008) 1 Year Follow-up (N = 272)5 Year Follow-up (N = 117) NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT NOTE: 4% of patients were on both calcineurin inhibitors at different point during the year; these patients are not counted in either group. And 1% (2 patients) was on neither drugs during the year. In the 5-year tabulations, 13% were reported to be on both drugs during the year and 1% (1 patient) was reported to be on neither drugs. Analysis is limited to patients who were alive at the time of the follow-up 2009

36. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG RECIPIENTS Maintenance Immunosuppression Drug Combinations at Time of Follow-up Report (Follow-ups: January 2001 – June 2008) NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT Analysis is limited to patients who were alive at the time of the follow-up 2009

37. J Heart Lung Transplant 2009;28: 989-1049 POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April 1994 - June 2008) ISHLT 2009

38. J Heart Lung Transplant 2009;28: 989-1049 POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April 1994 - June 2008) ISHLT 2009

39. J Heart Lung Transplant 2009;28: 989-1049 POST-LUNG TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Prevalence in Survivors within 7 Years Post-Transplant (Follow-ups: April 1994 - June 2008) ISHLT 2009

40. J Heart Lung Transplant 2009;28: 989-1049 Freedom from Bronchiolitis Obliterans Syndrome For Pediatric Lung Recipients (Follow-ups: April 1994 - June 2008) ISHLT 2009

41. J Heart Lung Transplant 2009;28: 989-1049 Freedom from Bronchiolitis Obliterans Syndrome For Pediatric Lung Recipients by Induction Use (Follow-ups: April 1994 - June 2008) ISHLT 2009

42. J Heart Lung Transplant 2009;28: 989-1049 Freedom from Severe Renal Dysfunction* For Pediatric Lung Recipients (Follow-ups: April 1994 - June 2008) ISHLT 2009

43. J Heart Lung Transplant 2009;28: 989-1049 MALIGNANCY POST-LUNG TRANSPLANTATION FOR PEDIATRICS Cumulative Incidence for Survivors (Follow-ups: April 1994 - June 2008) Malignancy/Type1-Year Survivors 5-Year Survivors 7-Year Survivors No Malignancy511 (94.1%)119 (86.9%)60 (89.6%) Malignancy (all types combined) 32 (5.9%)18 (13.1%)7 (10.4%) Malignancy Type Lymph29187 Other210 Other includes Liver and primitive neuroectodermal tumor. ISHLT 2009

44. J Heart Lung Transplant 2009;28: 989-1049 Freedom from Malignancy For Pediatric Lung Recipients (Follow-ups: April 1994 - June 2008) ISHLT 2009

45. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Cause Of Death (Deaths: January 1992- June 2008) CAUSE OF DEATH 0-30 Days (N =67) 31 Days - 1 Year (N = 118) >1 Year - 3 Years (N = 136) >3 Years - 5 Years (N = 68) >5 Years (N = 51) BRONCHIOLITIS 11 (9.3%)53 (39.0%)28 (41.2%)22 (43.1%) ACUTE REJECTION 2 (3.0%)3 (2.5%)1 (1.5%) LYMPHOMA 6 (5.1%)4 (2.9%)2 (2.9%)4 (7.8%) MALIGNANCY, NON- LYMPHOMA 1 (0.7%)1 (1.8%) CMV 5 (4.2%) INFECTION, NON-CMV 10 (14.9%)41 (34.7%)24 (17.6%)15 (22.1%)5 (9.8%) GRAFT FAILURE 20 (29.9%)22 (18.6%)35 (25.7%)11 (16.2%)12 (23.5%) CARDIOVASCULAR 10 (14.9%)6 (5.1%)2 (1.5%) TECHNICAL 10 (14.9%)3 (2.5%) MULTIPLE ORGAN FAILURE 5 (7.5%)8 (6.8%)7 (5.1%)3 (4.4%)3 (5.9%) OTHER 10 (14.9%)13 (11.0%)10 (7.4%)8 (11.8%)5 (9.8%) ISHLT 2009

46. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Other Cause Of Death (Deaths: January 1992- June 2006) CAUSE OF DEATH 0-30 Days (N =72) 31 Days - 1 Year (N = 107) >1 Year - 3 Years (N = 111) >3 Years - 5 Years (N = 56) >5 Years (N = 38) Graft Failure: Graft Infection4 (5.6%)3 2.8%)4 (3.6%)2 (5.3%) Graft Failure: Recurrent Disease1 (0.9%)1 (2.6%) Pulm: Pulmonary Embolism1 (1.4%)1 (1.8%) Cerebrovascular: Hemorrhage (Non-Stroke)3 4.2%)3 (2.8%) Cerebrovascular: Brain Anoxia1 (1.4%)1 (0.9%) Cerebrovascular: Other Specify3 4.2%) Hemorrhage: Gastrointestinal1 (0.9%) Hemorrhage: Respiratory1 (0.9%)1 (1.8%) Renal Failure1 (2.6%) Non-Compliance1 (0.9%)1 (1.8%) Primary Organ Failure1 (1.4%) Thromboembolic Disease1 (0.9%) Hus Hemolytic Uremic Syndrome1 (1.8%) Respiratory Failure1 (1.8%) ISHLT Last updated based on data as of December 2006 2009

47. J Heart Lung Transplant 2009;28: 989-1049 PEDIATRIC LUNG TRANSPLANT RECIPIENTS: Relative Incidence of Leading Causes of Death (Deaths: January 1992 - June 2008) ISHLT 2009

48. J Heart Lung Transplant 2009;28: 989-1049 N=738 ISHLT PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1990-6/2007) Risk Factors For 1 Year Mortality/Graft Failure 2009

49. J Heart Lung Transplant 2009;28: 989-1049 N=527 ISHLT PEDIATRIC LUNG TRANSPLANT RECIPIENTS (1/1990-6/2003) Risk Factors For 5 Year Mortality/Graft Failure 2009