1. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. HEART-LUNG TRANSPLANTATION Overall

2. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. NUMBER OF HEART-LUNG TRANSPLANTS REPORTED BY YEAR * Numbers may be low due to delayed reporting

3. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. HEART-LUNG TRANSPLANTATION ACTUARIAL SURVIVAL (1982-2001) N=2,928 Half-life = 2.8 years Conditional Half-life = 8.2 years Survival (%)

4. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. HEART-LUNG RECIPIENTS Functional Status (April 1994 – December 2001)

5. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. HEART-LUNG RECIPIENTS Employment Status (U.S.: April 1994 – December 2001)

6. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. HEART-LUNG RECIPIENTS: Rehospitalization Post-transplant (April 1994 - December 2001)

7. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. HEART-LUNG TRANSPLANTATION Adult Recipients

8. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS (1982-2001) Other includes cancer, LAM, OB, bronchiectasis, retransplant, sarcoidosis

9. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS (1982-2001) DiagnosisN% Congenital Heart Disease69336.4 PPH52027.3 CF34017.8 Acquired Heart Disease904.7 COPD/Emphysema874.6 IPF593.1 Alpha-1583.0 Re-TX: Non-OB311.6 Sarcoidosis271.4 Re-TX: OB221.2 Bronchiectasis130.7 OB (not Re-TX)90.5 Other522.7

10. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS BY ERA 1982-19901991-19951996-2001 Other includes OB (non-ReTX), Bronchiectasis, Sarcoidosis

11. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT HEART-LUNG RECIPIENTS Induction Immunosuppression For follow-ups between October 1999 and December 2001

12. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT HEART-LUNG RECIPIENTS Maintenance Immunosuppression at Any Time During Follow-up For follow-ups between October 1999 and December 2001

13. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT HEART-LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001

14. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT HEART-LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001

15. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT POST-HEART-LUNG TRANSPLANT MORBIDITY Cumulative Incidence of Survivors (April 1994-December 2001)

16. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. Freedom from CAV For Adult Heart-Lung Recipients (April 1994-December 2000)

17. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. Freedom from Bronchiolitis Obliterans For Adult Heart-Lung Recipients (April 1994-December 2000)

18. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. Freedom from Renal Dysfunction For Adult Heart-Lung Recipients (April 1994-December 2000) * Renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant

19. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. MALIGNANCY POST-HEART-LUNG TRANSPLANT FOR ADULTS Cumulative Incidence for Survivors (April 1994-December 2001) Malignancy/Type1-Year Survivors5-Year Survivors No Malignancy211 (90.9%)53 90.8%) Malignancy (all types combined)21 (9.1%)6 (9.2%) Malignancy Type Skin1 Lymph142 Other22 Type Not Reported42

20. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. Freedom from Malignancy For Adult Heart-Lung Recipients (April 1994-December 2000)

21. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death (1987-2001)

22. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. HEART-LUNG TRANSPLANTATION Pediatric Recipients

23. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTS (1982-2001)

24. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. AGE DISTRIBUTION FOR DONORS OF PEDIATRIC HEART-LUNG RECIPIENTS (1982-2001)

25. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTS By Year of Transplant Number of Transplants * Numbers may be low due to delayed reporting.

26. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. NUMBER OF CENTERS REPORTING PEDIATRIC HEART-LUNG TRANSPLANTS * Numbers may be low due to delayed reporting.

27. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. DIAGNOSIS IN PEDIATRIC HEART –LUNG TRANSPLANT RECIPIENTS (Age: 11-17 Years) Other includes Alpha-1, Bronchiectasis, IPF and OB (non-ReTX)

28. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. PEDIATRIC HEART-LUNG TRANSPLANTATION Actuarial Survival (1982-2001) Comparison between 1-10 years and 11-17 years not significant

29. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. PEDIATRIC HEART-LUNG TRANSPLANTATION Actuarial Survival by Era (1982-2001) Survival (%) No comparisons are statistically significant

30. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. PEDIATRIC HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death (1987-2001)