1. THE REGISTRY OF THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION: TWENTY-SECOND ANNUAL REPORT ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

2. MAJOR CONTRIBUTORS TO THE ISHLT TRANSPLANT REGISTRY Australia and New Zealand Cardiothoracic Organ Transplant Registry (ANZCOTR): Australia New Zealand Eurotransplant (ET): AustriaGermanySlovenia BelgiumNetherlands Scandiatransplant: DenmarkNorway FinlandSweden United Kingdom Transplant Services Authority (UKTSSA): United KingdomIreland United Network for Organ Sharing (UNOS): United States In addition, 72 individual centers from North America, Central/South America, Europe, Asia, and the Middle East have reported at least one transplant since 1995. ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

3. ACKNOWLEDGMENTS: We wish to extend our sincere thanks to the many thoracic transplant surgeons, physicians and data coordinators in transplant programs throughout the world whose timely and accurate submission of data has made these analyses possible. ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

4. REGISTRY STEERING COMMITTEE Marshall Hertz – Medical Director Elbert Trulock – Associate Dir. for Lung Transplantation David O. Taylor – Associate Dir. for Heart Transplantation Mark Boucek – Associate Dir. for Pediatric Transplantation Mario Deng – MCSD Database Medical Director Amanda Rowe – ISHLT Executive Director Berkeley Keck – Associate Dir. for Database Management Leah Edwards – Associate Dir. for Data Analysis ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

5. General Registry Statistics ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

6. REGISTRY DATABASE: Number of Transplants Reported ORGAN Transplants Reported from 7/1/2003 through 6/30/2004 Total Transplants Reported through 6/30/2004 Heart2,85870,201 Heart-Lung683,154 Lung1,65319,296 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

7. REGISTRY DATABASE: Number of Centers Reporting Transplants Organ Centers Ever Reporting Data Centers Reporting Transplants in 1995 Centers Reporting Transplants between 1/2003 and 6/2004 Heart338249201 Heart-Lung1335642 Lung203123111 ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

8. REGISTRY DATABASE: Number of Centers Reporting Heart Transplants ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

9. REGISTRY DATABASE: Number of Centers Reporting Lung Transplants ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

10. REGISTRY DATABASE: Number of Centers Reporting Heart-Lung Transplants ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

11. APPENDIX ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

12. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT ARGENTINA Fundacion Favaloroxx AUSTRALIA 1 St. Vincentxx The Prince Charles Hospitalxx Royal Childrens Hospitalxx The Alfred Hospitalxx Royal Perth Hospitalxx AUSTRIA 2 Universitätsklinik für Chirurgie, Wien xx Universitätsklinik für Chirurgie, Innsbruck xx Universitätsklinik für Chirurgie, Graz xx BELGIUM 2 Hôpital Erasme, Bruxellesxx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

13. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT BELGIUM 2 (contd) Onze Lieve Vrouw Ziekenhuis, Aalst xx Universitair Ziekenhuis Gasthuisberg, Leuven xx Universitair Ziekenhuis Antwerpen, Edegem xx Université Catholique de Louvain,Cliniques Universitaires St. Luc, Bruxelles xx Universitair Ziekenhuis, Gent xx Centre Hospitalier Universitaire, Liège xx CANADA Royal Victoria Hospital xx Montreal Heart Institute xx The Toronto General Hospital xx Hospital Notre-Dame xx Quebec Heart Institute - Laval Hospital xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

14. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT CANADA (contd) Univ. of Alberta Hospitals/ Walter C. Mackenzie Health Sciences xx St. Paulxx Vancouver General Hospitalxx The Hospital for Sick Childrenxx CHILE Hospital DIPRECAx Clinica Las Condesxx DENMARK 3 Skejby University Hospital xx Rigshospitalet, National University Hospital xx FINLAND 3 Helsinki University Central Hospital xx Children's Hospital, Univ. of Helsinki xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

15. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT FRANCE Hopital Cardiolgique (Lille) x Hopices Civils Hopital Universitaires de Strasbourg x GERMANY 2 Universitätsklinikum des Saarlandes, Homburg-Saar x Herzzentrum Dresden gmbh, Universitätsklinikum xx Deutsches Herzzentrum Berlinxx Universitäts-Krankenhaus Eppendorf, Klinik für Herz- und Gefässchirurgie, Hamburg xx Universitätsklinikum Kölnxx Universitätsklinikum Leipzig,Klinik für Abdominal-, Transplantations- und Gefässchirurgie xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

16. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT GERMANY 2 (contd) Klinikum der Universität, Regensburg xx Herz- & Diabeteszentrum Nordrhein- Westfalen, Bad Oeynhausen xx Universitätsklinikum Freiburgxx Universitätsklinikum Essen, Klinik für Thorax- und Kardiovaskuläre Chirurgie xx Klinikum der Johannes-Gutenberg- Universität, Mainz xx Heinrich-Heine-Universität Düsseldorf x Westfälischen Wilhelms-Universität, Münster xx Klinikum Großhadern der Ludwig- Maximilians-Universität, München xx Deutsches Herzzentrum München xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

17. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT GERMANY 2 (contd) Klinikum der Ruprecht-Karls- Universität, Chirurgischen Universitätsklinik, Abteilung für Herzchirurgie, Heidelberg xx Medizinischen Hochschule, Hannover xx Klinikum der Georg-August-Universität, Göttingen xx Universitätsklinikum der Rheinisch- Westfälischen TH, Aachen xx Klinikum Fulda, Thorax-, Herz-, und Gefässchirurgie xx Klinikum der Justus-Liebig-Universität, Gießen xx Universitätsklinikum Kiel, Klinik für Herz- und Gefässchirurgie, Kiel xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

18. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT GERMANY 2 (contd) Universitätsklinikum der Johann Wolfgang Goethe-Universität,Thorax- Herz- und Thorakale Gefässchirurgie, Frankfurt am Main xx Klinikum der Friedrich-Schiller- Universität, Jena xx Universitätsklinikum Erlangenxx GREECE Onassis Cardiac Surgery Center xx IRELAND 4 Mater Hospital xx ISRAEL Sheba Medical Center xx Ospedali Riuniti x (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

19. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT ITALY University Pavia xx Niguarda CA Granda Hospital x Policlinico S. Orsola - Universita degli Studi xx JAPAN Tohoku University, IDAC Hospital x Osaka University Hospital xx National Cardiovascular Center xx NETHERLANDS 2 Universitair Medisch Centrum Utrecht xx Erasmus MC, Universitair Medisch Centrum, Rotterdam xx Groningen Universitair Medisch Centrum xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

20. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT NEW ZEALAND 1 Green Lane Hospital xx NORWAY Rikshospitalet - National Hospital of Norway xx SLOVENIA 2 University Medical Center, Ljubljana xx SPAIN Hospital Clinic- Barcelona xx Hospital Central DE Asturias, Oviedo xx SWEDEN 3 University Hospital of Lund xx Sahlgrenska University Hospital xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

21. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT SWITZERLAND University Hospital Zurich x Univ Clinic for Cardiothoracic Surgery -Basel x TAIWAN China Medical College Hospital x UNITED KINGDOM 4 Great Ormand Street Hospital for Children xx University of Glasgow/Glasgow Royal Infirmary xx Northern General Hospital x The Freeman Hospital xx Harefield Hosp xx Wythenshawe Hospital xx Queen Elizabeth Hospital xx Papworth Hospital xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

22. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT UNITED STATES 5 University of Alabama Hospital xx Baptist Medical Center, Little Rock xx Arkansas Childrens Hospital xx The University Hospital of Arkansas xx University Medical Center, University of AZ xx Childrens Hospital Los Angeles xx Cedars Sinai Medical Center xx Loma Linda Univ. Medical Center xx California Pacific Medical Center xx UCSD Medical Center xx University of CA San Francisco Medical Center xx Sutter Memorial Hospital xx Sharp Memorial Hospital xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

23. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT UNITED STATES 5 (contd) Stanford University Medical Center xx St Vincent Medical Center xx UCLA Medical Center xx USC University Hospital xx The Childrens Hospital, Denver xx University Hospital, Denver xx Hartford Hospital xx Yale New Haven Hospital xx Childrens National Medical Center x Washington Hospital Center xx All Childrens Hospital xx Jackson Memorial Hospital xx St Lukes Hospital, Jacksonville xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

24. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT UNITED STATES 5 (contd) Tampa General Hospital xx Tallahassee Memorial Hospital x Shands Hospital at University of Florida xx Childrens Healthcare of Atlanta xx Emory University Hospital xx St. Joseph Hospital of Atlanta xx St. Francis Medical Center, Honolulu xx Univ. of Iowa Hospital and Clinics xx Childrens Memorial Hospital xx Loyola University Medical Center xx Rush University Medical Center xx OSF St. Francis Medical Center xx Univ. of Chicago Medical Center xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

25. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT UNITED STATES 5 (contd) University of Illinois Hospital xx Clarian Health-Methodist/IU/Riley xx Lutheran Hospital of Ft. Wayne xx St. Vincent Hosp. and Health Care Ctr xx Via Christi Regional Medical Center xx Jewish Hospital xx Kosair Childrens Hospital x Univ. of Kentucky Medical Center xx Ochsner Foundation Hospital xx Tulane University Medical Center xx Willis Knighton Medical Center xx Children's Hospital, Boston xx Massachusetts General Hospital xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

26. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT UNITED STATES 5 (contd) New England Medical Center xx Brigham and Womens Hospital xx Johns Hopkins Hospital xx Univ. of Maryland Medical System xx Childrens Hospital of Michigan xx Henry Ford Hospital xx Univ. of Michigan Medical Center xx Abbott Northwestern Hospital xx St. Marys Hospital (Mayo Clinic) xx Fairview University Medical Center xx Barnes-Jewish Hospital xx Cardinal Glennon Childrens Hospital xx St. Louis Childrens Hospital xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

27. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT UNITED STATES 5 (contd) St. Lukes Hospital of Kansas City xx St. Louis University Hospital xx Univ. of Missouri Hospital and Clinic x University of MS Medical Center xx NC Baptist Hospital xx Carolinas Medical Center xx Duke University Medical Center xx UNC Hospitals xx Bryan LGH Medical Center East xx Newark Beth Israel Medical Center xx Robert Wood Johnson Univ. Hosp xx Presbyterian Hospital, Albuquerque x Albany Medical Center Hospital xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

28. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT UNITED STATES 5 (contd) The Presbyterian Hospital in NY City xx Strong Memorial Hospital xx Montefiore Medical Center xx Mt. Sinai Medical Center xx Westchester County Medical Center xx Cleveland Clinic Foundation xx Childrens Hospital Dayton x Children's Hospital Medical Center, Cincinnati xx Medical College Hospital, Toledo x Ohio State University Hospital xx Univ. of Cincinnati Medical Center xx University Hospital of Cleveland xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

29. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT UNITED STATES 5 (contd) Integris Baptist Medical Center xx St. Francis Hospital, Tulsa xx Providence Portland Medical Center xx Oregon Health Sciences Univ. Hosp xx Allegheny General Hospital xx Childrens Hospital of Pittsburgh xx Childrens Hospital of Philadelphia xx Penn State Milton S Hershey Med Ctr xx Hahnemann University Hospital Tenet xx The Lankenau Hospital x Univ of Pittsburgh Medical Center xx Temple University Hospital xx The Hospital of the University of PA xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

30. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT UNITED STATES 5 (contd) Cardiovascular Center of PR xx Medical University of SC xx Baptist Memorial Hosp, Memphis xx St. Thomas Hospital xx Vanderbilt University Medical Center xx University Hospital, San Antonio xx Childrens Medical Center of Dallas xx Seton Medical Center xx Columbia Hosp at Medical City Dallas xx St Lukes Episcopal Hospital xx Methodist Specialty & Transplant Hospital xx University of Texas Medical Branch xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

31. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT UNITED STATES 5 (contd) The Methodist Hospital, Houston xx Christus Santa Rosa Medical Center xx St Paul University Hospital xx Texas Childrens Hospital Dallas xx Baylor University Medical Center xx LDS Hospital xx University of Utah Medical Center xx Primary Childrens Medical Center xx Inova Fairfax Hospital xx Henrico Doctors Hospital xx MCV Hospitals xx McGuire VA Medical Center xx Sentara Norfolk General Hospital xx (Contd) ISHLT 2005 J Heart Lung Transplant 2005;24: 945-982

32. Centers Reporting to the ISHLT Transplant Registry COUNTRY/Center TXs Performed in 2002 and Reported to ISHLT TXs Performed 1/2003-6/2004 and Reported to ISHLT UNITED STATES 5 (contd) University of Virginia HSC xx Childrens Hosp Medical Ctr, Seattle xx Sacred Heart Medical Center xx Univ. of Washington Medical Center xx Childrens Hospital of Wisconsin xx Froedtert Memorial Lutheran Hospital xx St Lukes Medical Center xx Univ. of Wisconsin Hosp. and Clinics xx ISHLT 2005 1 Data provided via Australia and New Zealand Cardiothoracic Transplant Registry (ANZCTR) 2 Data provided via Eurotransplant 3 Data provided via Scandiatransplant 4 Data provided via United Kingdom Transplant Support Service Authority (UKTSSA) 5 Data provided via United Network for Organ Sharing (UNOS) J Heart Lung Transplant 2005;24: 945-982