1. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. LUNG TRANSPLANTATION Overall

2. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND PROCEDURE TYPE 13 1547 80 185 408 686 902 1069 1204 13411337 1416 1413 1408 1508 1554 * Numbers may be low due to delayed reporting.

3. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. NUMBER OF LUNG TRANSPLANTS REPORTED BY YEAR AND LOCATION * Numbers may be low due to delayed reporting.

4. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. LUNG TRANSPLANTS: Donor Age by Year of Transplant

5. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS (1985-2001)

6. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. AGE DISTRIBUTION OF LUNG TRANSPLANT RECIPIENTS BY ERA 1985-19961997-2001

7. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. LUNG TRANSPLANTATION Actuarial Survival (1990-2000) Double lung: 1/2-life = 4.9 Years; Conditional 1/2-life = 7.9 Years Single lung: 1/2-life = 3.7 Years; Conditional 1/2-life = 5.9 Years All lungs: 1/2-life = 4.1 Years; Conditional 1/2-life = 6.5 Years

8. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. LUNG TRANSPLANTATION Adult Recipients

9. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTATION: Indications (1995-2001) DIAGNOSISSLT (N = 4,663)BLT (N = 4,118)TOTAL (N = 8,781) COPD/Emphysema2,53654.4%92622.5%3,46239.4% IPF1,11023.8%3769.1%1,48616.9% CF521.1%1,36033.0%1,41216.1% Alpha-14088.7%4079.9%8159.3% PPH611.3%3408.3%4014.6% Sarcoidosis1262.7%1062.6%2322.6% Bronchiectasis140.3%1764.3%1902.2% Congenital Heart Disease80.2%952.3%1031.2% LAM420.9%531.3%951.1% Re-TX: OB440.9%431.0%871.0% OB (Non-ReTX)320.7%501.2%820.9% Re-TX: Non-OB330.7%360.9%690.8% Connective Tissue Disorder 200.4%180.4%380.4% Cancer70.2%280.7%350.4% Histiocytosis X110.2%8 190.2% Other1593.4%962.3%2552.9%

10. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTATION: Indications (1995-2001) Single Lung Transplants Bilateral/Double Lung Transplants

11. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTATION Indications By Year

12. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTATION Actuarial Survival by Era (1988-2001) Survival comparisons by era 1988-1992 vs. 1993-1997: p = 0.007 1988-1992 vs. 1998-2001: p < 0.0001 1993-1997 vs. 1998-2001: p = 0.003

13. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTATION Actuarial Survival by Age Group (1990-2001) Survival comparisons by age group 18-34 vs. 50-64: p < 0.0001 18-34 vs. 65+: p = 0.0009 35-49 vs. 50-64: p < 0.0001 35-49 vs. 65+: p = 0.0004

14. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTATION Actuarial Survival By Diagnosis (1990-2001)

15. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTATION Actuarial Survival By Procedure Type Diagnosis: Alpha-1 Antitrypsin Deficiency (1990-2001) P = 0.03

16. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTATION Actuarial Survival by Procedure Type Diagnosis: Emphysema/COPD (1990-2001) P < 0.0001

17. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTATION Actuarial Survival by Procedure Type Diagnosis: IPF (1990-2001) P = 0.2

18. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTATION Actuarial Survival by Procedure Type Diagnosis: PPH (1990-2001) P = 0.4

19. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (1996-2001) Risk Factors for 1 Year Mortality In Descending Order of Magnitude N=5,242

20. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (1996-2001) Risk Factors for 1 Year Mortality In Descending Order of Magnitude N=5,242

21. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (1996-2001) Risk Factors for 1 Year Mortality Continuous Factors N=5,242

22. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (1996-2001) Risk Factors for 1 Year Mortality Continuous Factors N=5,242

23. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (1996-2001) Risk Factors for 1 Year Mortality Continuous Factors N=5,242

24. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (1996-2001) Factors Not Significant for 1 Year Mortality Steroid dependency Ischemia time % Predicted FeV1 % Predicted FVC Transfusions Diabetes Weight (donor) Height (donor) Donor clinical infection Donor history of hypertension Donor given steroids

25. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality In Descending Order of Magnitude N=3,098

26. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality In Descending Order of Magnitude N=3,098

27. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality Continuous Factors N=3,098

28. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality Continuous Factors N=3,098

29. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality Continuous Factors N=3,098

30. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (April 1994-December 1996) Factors Not Significant for 5 Year Mortality Steroid dependency Ventilator Ischemia time % Predicted FeV1 % Predicted FVC Transfusions Diabetes Weight (donor) Height (donor) Donor clinical infection Donor history of hypertension Donor given steroids

31. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year In Descending Order of Magnitude N=2,285

32. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS (April 1994-December 1996) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year Continuous Factors N=2,285

33. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG RECIPIENTS Functional Status (April 1994 – December 2001)

34. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG RECIPIENTS Employment Status (U.S.: April 1994 – December 2001)

35. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG RECIPIENTS: Rehospitalization Post-transplant (April 1994 - December 2001)

36. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG RECIPIENTS Induction Immunosuppression For follow-ups between October 1999 and December 2001

37. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG RECIPIENTS Maintenance Immunosuppression At Any Time During Follow-up Period For follow-ups between October 1999 and December 2001

38. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG RECIPIENTS Maintenance Immunosuppression At Time of Follow-up For follow-ups between October 1999 and December 2001

39. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001 1 Year Follow-up (N = 1,177)5 Year Follow-up (N = 547)

40. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001

41. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. POST-LUNG TRANSPLANT MORBIDITY For Adult Recipients (April 1994-December 2001)

42. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. Freedom from Bronchiolitis Obliterans For Adult Lung Recipients (April 1994-December 2000)

43. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. Freedom from Renal Dysfunction* For Adult Lung Recipients (April 1994-December 2000) * Renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant

44. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. MALIGNANCY POST-LUNG TRANSPLANTATION FOR ADULTS Cumulative Incidence for Survivors (April 1994-December 2001) Malignancy/Type1-Year Survivors5-Year Survivors No Malignancy4,583 (96.0%)731 (87.2%) Malignancy (all types combined)189 (4.0%)107 (12.8%) Malignancy Type Skin3754 Lymph9115 Other3921 Lymph + Skin3 Lymph + Other4 Skin + Other2 Type Not Reported228

45. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. Freedom from Malignancy For Adult Lung Recipients (April 1994-December 2000)

46. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANT RECIPIENTS: Cause Of Death (1982-2001) 0-30 Days (N = 962) 31 Days - 1 Year (N = 1,230) >1 Year - 3 Years (N = 953) >3 Year - 5 Years (N = 479) CAD121.2%100.8%111.2%71.5% Cardiac899.3%443.5%202.1%153.1% Malignancy, Other00.0%241.9%394.1%387.9% Lymphoma10.1%403.2%232.4%81.7% CMV50.5%514.0%161.7%30.6% Acute Rejection575.9%554.4%202.1%40.8% Infection, Non-CMV23724.6%48438.3%23724.9%9018.8% Bronchiolitis70.7%755.9%28630.0%15833.0% Primary Graft Failure15816.4%755.9%555.8%194.0% Graft Failure - Other14114.7%14011.1%9710.2%6613.8% Technical858.8%383.0%90.9%10.2% Other17017.7%22718.0%14014.7%7014.6% Total962100.0%1263100.0%953100.0%479100.0%

47. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANT RECIPIENTS: Cause Of Death (1982-2001) Timing of Death

48. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in 0-30 Days Year of Transplant

49. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in 31 Days – 1 Year Year of Transplant

50. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in >1 Year – 3 Years Year of Transplant

51. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in >3 Years – 5 Years Year of Transplant

52. 2002 ISHLT J Heart Lung Transplant 2002; 21: 950-970. ADULT LUNG TRANSPLANTS RECIPIENTS: Cause of Death by Era: Deaths in >5 Years Year of Transplant