1. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. HEART TRANSPLANTATION Pediatric Recipients

2. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. AGE DISTRIBUTION OF PEDIATRIC HEART RECIPIENTS (1982-2001)

3. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. AGE DISTRIBUTION FOR DONORS OF PEDIATRIC HEART RECIPIENTS (1982-2001)

4. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. AGE DISTRIBUTION OF PEDIATRIC HEART RECIPIENTS By Year of Transplant Number of Transplants 119 4242 75 109 13 0 19 3 254 326 365 363 385 364 378 349 372 350 340 356 319 * Numbers may be low due to delayed reporting.

5. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. NUMBER OF CENTERS REPORTING PEDIATRIC HEART TRANSPLANTS * Numbers may be low due to delayed reporting

6. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. DIAGNOSIS IN PEDIATRIC HEART TRANSPLANT RECIPIENTS (Age: < 1 Year)

7. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. DIAGNOSIS IN PEDIATRIC HEART TRANSPLANT RECIPIENTS (Age: 1-10 Years)

8. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. DIAGNOSIS IN PEDIATRIC HEART TRANSPLANT RECIPIENTS (Age: 11-17 Years)

9. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival (1982-2001) <1 year vs. 1-10 years: p = 0.0005 <1 year vs. 11-17 years: p = 0.001

10. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTATION Conditional Actuarial Survival (1982-2001) Both comparisons with 11-17 years significant at p < 0.0001

11. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTATION Conditional Actuarial Survival for Recent Era (1998-2001) Comparison of <1 vs. 11-17 years significant at p = 0.01

12. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival by Era (1982-2001) All comparisons with 1998-2001 are significant at p < 0.0001 Comparison of 1982-1987 vs. 1988-1992 was significant at p = 0.003 Comparison of 1982-1987 vs. 1993-1997 was significant at p < 0.0001 Survival (%)

13. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival by Age Group For Diagnosis = Cardiomyopathy (1988-2001) Survival (%) No comparisons were statistically significant.

14. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival By Age Group For Diagnosis = Congenital Disease (1988-2001) Comparison of <1 vs. 11-17 was significant at p = 0.01 Survival (%)

15. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTS (1996-2001) Risk Factors For 1 Year Mortality In Descending Order of Magnitude N=1,554

16. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTS (1996-2001) Risk Factors for 1 Year Mortality Continuous Factors N=1,554

17. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTS (1996-2001) Factors Not Significant for 1 Year Mortality Previous Transplant Donor history of hypertension Height (recipient/donor) Weight (recipient/donor) Gender (recipient/donor) Age (donor) Year of transplant In ICU or hospital Donor clinical infection ICD Ischemia time Center volume PRA Total bilirubin

18. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTS (April 1994 - December 1996) Risk Factors For 5 Year Mortality In Descending Order of Magnitude N=937

19. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTS (April 1994 - December 1996) Risk Factors For 5 Year Mortality Continuous Factors N=937

20. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTS (April 1994 - December 1996) Factors Not Significant for 5 Year Mortality Donor history of hypertension Height (recipient/donor) Weight (donor) Gender (donor) Age (donor) Donor cause of death In ICU or hospital Donor clinical infection ICD Ischemia time Center volume PRA Total bilirubin

21. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTS (April 1994 - December 1996) Risk Factors for 5 Year Mortality Conditional on Survival to 1 Year In Descending Order of Magnitude N=728

22. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Functional Status (April 1994-December 2001)

23. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Rehospitalization Post-transplant (April 1994 - December 2001)

24. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Induction Immunosuppression For follow-ups between October 1999 and December 2001

25. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Maintenance Immunosuppression at Any Time During Follow-up Period For follow-ups between October 1999 and December 2001

26. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001

27. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001 1 Year Follow-up (N=429)5 Year Follow-up (N = 303)

28. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Maintenance Immunosuppression at Time of Follow-up For follow-ups between October 1999 and December 2001

29. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. POST-HEART TRANSPLANT MORBIDITY FOR PEDIATRICS Cumulative Incidence for Survivors (April 1994-December 2001)

30. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. Freedom from CAV For Pediatric Heart Recipients (April 1994-December 2000)

31. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. Freedom from Renal Dysfunction* For Pediatric Heart Recipients (April 1994-December 2000) * Renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant

32. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. MALIGNANCY POST-HEART TRANSPLANTATION FOR PEDIATRICS Cumulative Incidence for Survivors (April 1994-December 2001) Malignancy/Type1-Year Survivors5-Year Survivors No Malignancy1,547 (98.2%)378 (95.2%) Malignancy (all types combined)29 (1.8%)19 (4.8%) Malignancy Type Lymph2518 Other31 Type Not Reported1

33. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. Freedom from Malignancy For Pediatric Heart Recipients (April 1994-December 2000)

34. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival Based on Prednisone Use p = 0.005

35. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival Based on Rejection within 1 st Year P = 0.09

36. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Relationship of Prednisone Use and CAD Transplants: April 1994 – December 1999 Prednisone Use at Discharge and at 1 Year Reported CAD between 1 st and 2 nd years post- transplant Reported CAD between 1 st and 3 rd years post- transplant YesNoYesNo Yes28 4.8% 558 95.2% 27 7.1% 352 92.9% No4 2.8% 138 97.2% 2 2.0% 96 98.0% p = 0.4 p = 0.06

37. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Relationship of Rejection and CAD Transplants: April 1994 – December 1999 Rejection During 1 st Year Reported CAD between 1 st and 2 nd years post- transplant Reported CAD between 1 st and 3 rd years post- transplant YesNoYesNo Yes19 5.3% 342 94.7% 17 7.1% 222 92.9% No6 1.8% 322 98.2% 7 3.2% 212 96.8% p = 0.02 p = 0.09

38. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Incidence of Hypertension between 1 and 3 Years Maintenance Immunosuppression at discharge and 1 year On immuno: % HTN reported between 1 and 3 years Not on immuno: % HTN reported between 1 and 3 years P-value Cyclosporine20.3%15.7%0.6 Tacrolimus20.5%19.4%0.8 Azathioprine22.3%15.3%0.3 Prednisone29.9%6.4%<0.0001

39. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Incidence of Hypertension by 3 Years Maintenance Immunosuppression at discharge and 1 year On immuno: % HTN reported by 3 years Not on immuno: % HTN reported by 3 years P-value Cyclosporine48.8%40.6%0.2 Tacrolimus44.2%46.2%0.8 Azathioprine51.1%42.4%0.1 Prednisone59.5%12.1%<0.0001

40. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Growth Following Transplantation: Height Stratified by Prednisone Use at Discharge and at 1 Year

41. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS Growth Following Transplantation: Weight Stratified by Prednisone Use at Discharge and at 1 Year

42. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART RECIPIENTS: Time of Death (1988-2001)

43. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANT RECIPIENTS: Cause of Death (1982-2001) Timing of Death Cause of Death (%)

44. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTS RECIPIENTS: CAUSE OF DEATH BY ERA: Deaths in 0-30 Days

45. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTS RECIPIENTS: CAUSE OF DEATH BY ERA: Deaths in 31 Days - 1 Year

46. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTS RECIPIENTS: CAUSE OF DEATH BY ERA: Deaths in >1 Year - 3 Years

47. 2002 ISHLT J Heart Lung Transplant 2002; 21: 827-840. PEDIATRIC HEART TRANSPLANTS RECIPIENTS: CAUSE OF DEATH BY ERA: Deaths in >3 Years - 5 Years