1. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings PowerPoint ® Lecture Slide Presentation prepared by Christine L. Case Microbiology B.E Pruitt & Jane J. Stein AN INTRODUCTION EIGHTH EDITION TORTORA FUNKE CASE Chapter 25, part A Microbial Diseases of the Digestive System

2. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Microbial Diseases of the Digestive System Transmitted in food and water Fecal-oral cycle can be broken by: Proper sewage disposal Disinfection of drinking water Proper food preparation and storage

3. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings The Digestive System Figure 25.1

4. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings >300 species in mouth Large numbers in large intestine, including: Bacteroides E. coli Enterobacter Klebsiella Lactobacillus Proteus Normal Microbiota

5. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Dental Caries Figure 25.3a, b

6. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Tooth Decay Figure 25.4

7. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Periodontal Disease Figure 25.5

8. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Symptoms usually include diarrhea, gastroenteritis, dysentery Treated with fluid and electrolyte replacement Infection caused by growth of pathogen Incubation from 12 hr to 2 wk Intoxication caused by ingestion of toxin Symptoms appear 1-48 hr after ingestion Bacterial Diseases of the Lower Digestive System

9. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Staphylococcal Food Poisoning Figure 25.6 Staphylococcus aureus enterotoxin is a superantigen

10. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Shigellosis Figure 25.8 Shigella spp. producing Shiga toxin Shiga toxin causes inflammation and bleeding

11. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Salmonellosis Figure 25.9 Salmonella enterica serovars such as S. enterica Typhimurium Mortality (<1%) due to septic shock caused by endotoxin

12. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Salmonellosis and Typhoid Fever Incidence Figure 25.10

13. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Salmonella enterica Typhi Bacteria spread throughout body in phagocytes 1-3% recovered patients become carriers, harboring Salmonella in their gallbladder Typhoid Fever

14. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Cholera Figure 25.12 Vibrio cholerae serotypes that produce cholera toxin Toxin causes host cells to secrete Cl –, HCO –, and water

15. Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Usually from contaminated crustaceans or mollusks V. cholerae serotypes other than O:1, O:139, and eltor V. parahaemolyticus V. vulnificus Noncholera Vibrios