1. Italian HIV/AIDS situation 8th Advanced HIV Course -Montpellier, France 8-10 September 2010 Alessia Uglietti San Matteo Hospital, Pavia Carmela Calbi Spallanzani Hospital, Rome Manuela Pogliaghi, San Raffaele Hospital, Milan Francesca Vignale SS Annunziata Hospital, Chieti

2. Years of diagnosis Incidence /100000 inhabitants HIV incidence estimates males females Total

3. HIV in Italy: differences between 1988 - 2008 New diagnosis of HIV infection in 1988 Main risk factor: injective drug users (71%) Median age at the first positive test : 27 yrs Foreigners: 4% New diagnosis of HIV infection in 2008 Main risk factor: sexual intercourses (hetero/homo) (74%) Median age at the first positive test : 39 yrs Foreigners : 32% 3.900-4.100 14.000-18.000 Persons living with HIV/AIDS in 2008 ~ 160.000 1988 2008

4. % Years of diagnosis IDUMSM HeterosexOther/Unkonwn Percent distribution of new diagnosis of HIV infection, by mode of transmission and year

5. Italians Foreigners Years of diagnosis % HIV incidence estimates: nationality Africa 41.2% Latin America 25.2% Europe 16% Asia and Oceania 16.2% North America 1.4%

6. AIDS epidemiology in Italy from 1982 to now New AIDS cases/year: 5.655 1995 (peak of disease) 2009* * Data at Nov. 2009 Total cases of mother to child transmission Total AIDS cases from the beginning of epidemic ~ 62.000 Total AIDS deaths from the beginning of epidemic ~ 39.500 Females ~ 27% ~ 716 Injection drug users (62,5%) Main risk factor: ~1.200 New AIDS cases/year: Main risk factor: hetero/homosexual intercourses (~69%) 35 years Median age at diagnosis: 43 years Median age at diagnosis: 4,7% Foreigners: ~24% Foreigners:

7. Years of diagnosis Number of cases Rate/100000 inhabitants AIDS cases in Italy Reported cases Corrected Incidence rate

8. Conclusions 1.Improve the prevention and information on HIV infection and testing: in all pregnant women in population groups with high HIV prevalence in all persons: opt-out opt-in 2.Identify infection in those persons who are unaware of their seropositivity 3.Need to adjust therapy, support and healh-care assistance in patients groups and individuals 4.Increase additional financial and human resources

9. Thank you for your attention