1. Brain Awareness Training Session 2014 BAC GRAD709 Student Advisor: Amie Severino

2. Outline What’s BAC? – Steering Committee – Links – Activities Activities in Depth

3. What is the BAC? An official graduate student organization – Steering committee – Faculty advisors – Grant funding Our general membership is comprised of: – Undergraduates – Graduate students – Post Docs – Medical students – Faculty and staff – Whoever is in this room

4. BAC Steering Committee Committee Coordinator School Visit Coordinator Brain Awareness Chair Neuroflix Chair Materials Management Chair – Lending Library Chair Public Relations Chair Website/Internal Communications Chair

5. BAC Website Links http://bac.graduate.wfu.edu/ brainawareness.wikispaces.com/home

6. BAC Activities Multiple Outreach Initiatives – School Visits – Brain Awareness Week – Neuroflix – Learning lending library

7. School Visits Stations work best for younger students – We are using ~20-30 minute stations (K-8) 90 minute lectures with human and comparative brains keep highschoolers stable NEWish: School visit coordinator position for each visit – Bringing and returning materials (2 hours credit)

8. Human Brains Station

9. Other Stations Visual Plasticity Build-A-Neuron Anatomy Coloring Two-Point Discrimination

10. Before a Visit http://brainawareness.wikispaces.com/ Sign up for your sessions in advance GRAD709 has priority Use the handbook to plan and guide your lesson (don’t show up totally unprepared)

11. At the Visit BE ON TIME and “ON TIME” IS 15 MINUTES EARLY Don’t panic, shadow someone if you’re new or uncomfortable Make sure you know who the visit coordinator is and return your materials to them

12. Visit Materials Station or Lecture Style – Stations Descriptions Human and Comparative Animal Brains Build a Neuron Visual illusions and adaptation 2 Point Discrimination Anatomy Coloring – Lecture Powerpoint Brains (Human and Comparative Animal)

13. Brain Awareness Week Community event Children’s Museum SciWorks Stations Style Presentations for all ages

14. Neuroflix Free, community-oriented movie events hosted every semester by the BAC A film with neuroscience theme is selected to screen at a local venue A panel facilitates a discussion of the film afterwards – local informed community members, clinicians, researchers Adult oriented activity – 25 to 50 people per event attend

16. Lending Library “BAC in a box” o CNS and PNS models o Human and animal brains o Self-contained educational resource o Promotes interactive learning o Teachers report improved test scores

17. Sales Pitch: How this Benefits You 1.Sense of fulfillment 2.Better familiarity with topics in neuroscience 3.Outreach/community service hours 4.Teaching experience 5.Networking o Within the university o National conferences: SfN o Local industry and businesses, media 6.Resume/C.V. builder

18. GRAD 709 Course

19. Notes for GRAD709 GRAD709 Course – 1.5 hours for this meeting – 10 hours required for K-12 visits 2 weeks notice of cancellation – Penalties for late changes (extra hours) More than 1 unexplained absence results in the U grade (Unsatisfactory)

20. BAC School Visit Powerpoint

21. Outline BBrain Anatomy SStructures and functions DDisorders caused by lesions CComparative Anatomy BBrain Function CCells in the brain HHow brain cells communicate DDrugs on the Brain MMechanisms of action DDrug addiction

22. Or Lateral Sulcus Structural Anatomy

23. Functional Anatomy Executive Function Functional Areas of the Brain

24. Language WERNICKES AREA: LANGUAGE COMPREHENSION BROCA’S AREA: LANGUAGE PRODUCTION

25. Wernicke’s Aphasia

26. Broca’s Aphasia

27. Two Interconnected Hemispheres

28. Split-Brain Phenomenon

29. Internal Structures of the Brain

31. VENTRICULAR SYSTEM

32. Comparative Anatomy: Structure = Function Brain structure tells us a lot about how smart an organism is, how it interacts with the world, etc.

33. RAT BRAIN

34. CAT BRAIN

35. PIG BRAIN

36. MONKEY BRAIN

37. Neurons: Cellular Communicators DENDRITES NUCLEUS CELL BODY AXON MYELIN SHEATH AXON TERMINALS

38.  Electrical Signal  Action Potential  Chemical Signal  Neurotransmitter Release  Receptor Binding Neurons: Cellular Communicators

39. Neurons Form Networks

40. Action Potential

41. Drugs of Abuse How do drugs like nicotine and alcohol affect the brain? Why do these drugs produce a “high” while other drugs that act on the brain (such as asprin) don’t have this effect?

42. Drugs Hijack Brain Pathways (endogenous vs exogenous ligands)

43. Example: Dopamine Reward Pathway

44. Cocaine Increases “Reward” Signal

45. Mechanisms (Simplified) http://learn.genetics.utah.edu/content/addict ion/drugs/mouse.html

46. What is tolerance?  Tolerance occurs when you are abusing a substance/drug and over time your sensitivity to that substance decreases.  Higher quantities of the substance/drug must be consumed in order to achieve the same effects as before.  For example, a person has to drink more alcohol to reach a “buzz” than when he/she started drinking for the first time.

47. What is physical dependence?  Dependent upon a substance/drug to have normal function.  Develop negative withdrawal symptoms when the substance/drug is no longer on board.  Withdrawal symptoms are basically the opposite of the drug effects  Withdrawal from stimulants: depression, lethargy  Withdrawal from depressants: anxiety, sleeplessness

48. What is a standard drink?

49. What is Moderate Drinking? WomenMen Moderate Drinking (“Low Risk”) Per Day 3 or less4 or less Moderate Drinking (“Low Risk”) Per Week No more than 7 drinks No more than 14 drinks  Heavy drinking would be considered consuming more than the daily amount or weekly amount listed in the table.

50. Alcohol Effects: Chronic Use Normal “Happy” Brain

51. Your brain wants to compensate Alcohol on the Brain

52. Your brain wants to compensate Alcohol Withdrawal

53. What is considered a binge?  Binge drinking is consuming so much alcohol that your blood alcohol concentration (BAC) reaches 0.08g/dl or higher within 2 hours.  For women: 4 drinks or more within 2 hours  For men: 5 drinks or more within 2 hours

54. Withdrawal symptoms increase in severity after multiple relapses

56. Alcoholism can cause loss of brain matter over time

57. Impaired Brain Activity in Alcohol Dependence

58. Questions?