1. Rx for Science Literacy Care and Use of Animals in Research Darrell E. Hoskins, DVM, Dipl. ACLAM Director, Animal Welfare Training

2. Why Animals? Why Animals? 21st _____________ ______________ demand medical advancements and safety. 21st century _____________ ______________ demand medical advancements and safety. “societal expectations”

3. Why Animals? Why Animals? -ethical issues -not instead of, but prior to research in humans -animals benefit too -no substitute yet -decreased scientific variables, increased consistency -life span and generation time

4. Use of Animals Annually Use of Animals Annually Use of animals by humans is a historical constant; “awareness” of animal use is the __________________. “variable”

5. Animal Use in the US

6. Research Animals in the US

7. -perspectives on numbers of animals used by humans -species selections -purpose-bred vs. random source animals Use of Animals Annually Use of Animals Annually

8. Professionals in Research Animal Care Professionals in Research Animal Care Research animal care professionals have chosen to assume society’s for protecting the wellbeing of research animals. Research animal care professionals have chosen to assume society’s _______________ for protecting the wellbeing of research animals. “responsibility”

9. -American College of Laboratory Animal Medicine -American Association for Laboratory Animal Science -Corporate Initiatives (animal welfare and quality science go hand-in-hand) Professionals in Research Animal Care Professionals in Research Animal Care

10. AALAS Professional Journals

11. Oversight of Research Animal Welfare Oversight of Research Animal Welfare The “3 R’s”, ___________________, ___________________, and ______________ serve as the central guiding principal for all professional and regulatory oversight activities in biomedical research. “reduction, refinement, replacement”

12. Oversight of Research Animal Welfare Oversight of Research Animal Welfare - USDA Animal Welfare Act - AAALAC -OLAW/PHS Policy -FDA, EPA, OSHA, CPSC, etc. -government scientific review panels

13. Institutional Animal Care and Use Committees (IACUCs) Institutional Animal Care and Use Committees (IACUCs) The IACUC is a federally mandated entity that assures the _____________ of research animals and represents the interests of the ______________. welfare public

14. - membership -protocol review -inspections/reviews -investigate concerns Institutional Animal Care and Use Committees (IACUCs) Institutional Animal Care and Use Committees (IACUCs)