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2002 7WCGALP (HDN-1) Performance of Holstein clones in the United States H.D. NORMAN,*,1 T.J. LAWLOR, 2 and J.R. WRIGHT 1 1 Animal Improvement Programs Laboratory Agricultural Research Service, USDA Beltsville, MD 20705-2350, USA 2 Holstein Association USA, Brattleboro, VT 05302, USA *dnorman@aipl.arsusda.gov 301-504-8334 Photo courtesy Infigen
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2002 7WCGALP (HDN-2) National Research Council (USA) Subcommittee to identify and to prioritize science-based risks of genetically modified animals Report will decide regulation of cloned animals by U.S. Food and Drug Administration
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2002 7WCGALP (HDN-3) Cloning technology Embryo splitting First U.S. registered Holstein calves: 1982 Identical nuclear and mitochondrial DNA Nuclear transfer First U.S. registered Holstein calves: 1989 Nearly identical nuclear DNA, but different mitochondrial DNA Almost no recording of recipient cell identity Full siblings versus identical animals
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2002 7WCGALP (HDN-4) Objectives Document performance of clones: Yield: milk, fat, protein Fitness: somatic cell score (SCS), productive life (PL) Examine performance differences between embryo-split and nuclear- transfer clones
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2002 7WCGALP (HDN-5) Data Holstein Association USA registrations for embryo- split and nuclear-transfer clones Gender Birth year Pedigree merit Mean of parent predicted transmitting abilities (PTAs) Clone type (embryo split vs. nuclear transfer) All U.S. Holsteins born in same year and milk recorded through Dairy Herd Improvement
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2002 7WCGALP (HDN-6) Embryo-split clone population
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2002 7WCGALP (HDN-7) Nuclear-transfer clone population
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2002 7WCGALP (HDN-8) Female pedigree merit: Milk Birth year Mean of parent PTAs (kg) Embryo splitNuclear transferPopulation 1983-487...-645 1985-283...-554 1987-322...-459 1989-211-113-344 1991-33+46-233 1993+88-29-114 1995+146...0 1997+342...+122 1999+432+645+206
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2002 7WCGALP (HDN-9) Female pedigree merit: Fat Birth year Mean of parent PTAs (kg) Embryo splitNuclear transferPopulation 1983-15...-22 1985-10...-19 1987-9...-15 1989-2-3-10 1991+1+3-7 1993+4 -4 1995+6...0 1997+10...+4 1999+12 +6
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2002 7WCGALP (HDN-10) Female pedigree merit: Protein Birth year Mean of parent PTAs (kg) Embryo splitNuclear transferPopulation 1983-13...-18 1985-10...-16 1987-10...-14 1989-5-2-10 19910+2-7 1993+5+1-3 1995+5...0 1997+13...+4 1999+15+23+7
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2002 7WCGALP (HDN-11) Mean standardized traits Embryo splittingNuclear transfer Trait ClonesFull sibs ClonesFull sibs Milk (kg)10,57710,85010,19710,052 Fat (kg)386394367368 Fat (%)3.663.623.613.66 Protein (kg)315324317306 Protein (%)2.98 3.123.03 SCS3.03.13.73.1 PL (mo)25.625.321.430.3
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2002 7WCGALP (HDN-12) Deviation from contemporaries Embryo splittingNuclear transfer Trait ClonesFull sibs ClonesFull sibs Milk (kg)-273-93-525-519 Fat (kg)-5-24-15 Protein (kg)-50-8-11
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2002 7WCGALP (HDN-13) Mean PTA Embryo splittingNuclear transfer Trait Clone s Full sibs Clone s Full sibs Milk (kg)-67-34-105-63 Fat (kg)00-50 Fat (%)0.02 -0.010.02 Protein (kg)0000 Protein (%)0.01 0.030.02 SCS3.09 3.163.14 PL (mo)0.10.2-0.4-0.1
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2002 7WCGALP (HDN-14) Famous split-embryo bulls Bull Daugh- ters (no.) PTA Milk (kg) Fat (kg) Pro- tein (kg) Produc- tive life (mo) Somatic cell score Duplicate477+156-19-7-0.83.28 Divide606+143-18-7-0.73.26 Wind Kaddy5032+347+13+10-1.13.55 SW Kaddy506+261+14+8-1.13.48
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2002 7WCGALP (HDN-15) Decreased number of embryo-split males and all nuclear-transfer clones Animals selected for cloning slightly superior genetically to population for yield traits Yields similar for nuclear-transfer clones and their non-cloned full siblings Yields of embryo-split clones slightly less than yields of their non-cloned full siblings Conclusions
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