1. Antineoplastics and Immunomodulating Agents
EO Part 24

2. Overview of Lesson (Insert Dari)
Antineoplastic Agents
- Imatinib
- Methotrexate
Immunomodulating Agents

3. What I need to know as a pharmacy technician (Insert Dari)
In this lecture we will cover the drugs listed in the ANA Formulary which are classified according to the ATC system under
(L) Antineoplastics and Immunomodulating Agents
For each of these medications/classes students must obtain an understanding of:
(1) Mechanism of Action
(2) Indications (Uses)
(3) Efficacy
(4) Side Effects
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5. Antineoplastic Agents (Insert Dari)

6. What is Neoplasia (Cancer)? (Insert Dari)
Abnormal cell growth. Can result in the formation of a tumour or invasion of another area of the body.
This is a very wide group of diseases.
Below are a few examples:
Leukemia (cancer of the bone marrow)
Lung cancer
Breast cancer
Prostate cancer
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Tumour of the left lung
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9. Imatinib (Insert Dari Insert Dari Mechanism of Action
Stops abnormal cell growth. Can also affect healthy cells which lead to side effects.
Indication
Used to treat cancer (mainly leukemia and stomach cancer).
Side Effects
Signs of infection (fever chills)
Trouble thinking clearly
Weight gain
Swelling in the limbs
Liver problems.
Abnormal bruising or bleeding

10. Imatinib (Insert Dari Insert Dari Important Information
This medication is taken orally.
Take this drug at the same time of day.
Take this drug with food.
Be sure to drink lots of water while taking this medication.

11. Methotrexate (Insert Dari)
Mechanism of Action
Interferes with the synthesis of folic acid in cells undergoing abnormal growth, which prevents cell replication.
Indications (Use)
• It is used to treat arthritis.
• It is used to treat cancer.
• It is used to treat leukemia.
• It is used to treat psoriasis.
• It is used to treat bowel disease.

12. Methotrexate (Insert Dari)
Side Effects
Anemia
Increased risk of infection
Upset stomach
Loss of appetite
Diarrhea
Mouth sores
Headache
Hair loss
Harm to the liver or kidney
Important Points
Patients will be more sensitive to the sun.
Contraindicated in pregnancy.

13. Immunostimulants (Insert Dari)

14. Interferon Alpha (Insert Dari)
Mechanism of Action
Increases immune response.
Indications (Use)
• It is used to treat cancer.
• It is used to treat genital warts.
• It is used to treat hepatitis B and C infections.
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15. Interferon Alpha (Insert Dari)
Side Effects
Flu-like symptoms (aches, fever, chills).
Anemia.
Low mood.
Dry mouth.
Loss of Appetite.
Feeling lightheaded.
Upset stomach
Important Points
Contraindicated in pregnancy.

16. Questions? (Insert Dari)

17. In-class Assignment (Insert Dari)
This assignment will consist of 2 questions which are to be completed individually.
Once complete the instructor will review the answers with the class.
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18. 1. What is a neoplasia (cancer)? (Insert Dari)
Abnormal cell metabolism
Abnormal cell growth resulting in tumours or invasion of cells into another area of the body.
Abnormal cell movement
Abnormal cell function

19. 1. Answer: What is a neoplasia (cancer)? (Insert Dari)
Abnormal cell metabolism
Abnormal cell growth resulting in tumours or invasion of cells into another area of the body.
Abnormal cell movement
Abnormal cell function

20. 2. How does Methotrexate work? (Insert Dari)
Interferes with folic acid synthesis
Interferes with protein synthesis
Interferes with cell wall synthesis
Causes cell lyses
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21. 2. Answer: How does Methotrexate work? (Insert Dari)
Interferes with folic acid synthesis
Interferes with protein synthesis
Interferes with cell wall synthesis
Causes cell lyses
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