1. 2004-2005 First Year Review (only Principles drugs have been updated; doesn’t include Derm) 21 September 2015 2:13 PM

2. Abciximab Antiplatelet Anti-GPIIb/IIIa receptor antibody

3. Acetaminophen Analgesic, Antipyretic

4. Adalimumab TNF inhibitor Anti-TNF antibody Used in rheumatoid arthritis

5. Adrenocorticotropin (ACTH) Anterior pituitary hormone Anticonvulsant Stimulates synthesis and release of cortisol

6. Alemtuzumab Antineoplastic Anti-CD52 antibody

7. Alfentanil Opioid General anaesthetic Intravenous anaesthetic

8. Allopurinol Antigout Antineoplastic (supporting agent) Folic acid analogue Xanthine oxidase inhibitor

9. Amantadine Antiviral Antiparkinson Treatment of Influenza A Inhibits replication at the stage of uncoating Inhibits dopamine release

10. Amikacin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation

11. Aminocaproic acid (EACA) Procoagulant Inhibitor of plasminogen activation (decreases fibrinolysis)

12. Aminoglutethimide Antineoplastic Immunosuppressive Glucocorticoid antagonist Aromatase inhibitor (decreases steroid synthesis)

13. Aminoglycosides Antibiotics Bactericidal protein synthesis inhibitors 30S ribosome Freeze initiation

14. Amitriptyline Tricyclic antidepressant (TCA)

15. Amoxicillin Penicillin antibiotic Cell wall synthesis inhibitor Antiulcer Amino penicillin Inhibits peptidoglycan cross-linking

16. Amphetamine Indirect sympathomimetic Drug of abuse ADD treatment Stimulant

17. Ampicillin Penicillin antibiotic Cell wall synthesis inhibitor Amino penicillin Inhibits peptidoglycan cross-linking

18. Amsacrine Antineoplastic Miscellaneous

19. Angiostatin Antineoplastic Angiogenesis inhibitor

20. Anistreplase Thrombolytic Streptokinase + plasminogen

21. Anti-thymocyte globulin Immunosuppressive Anti-T cell antibody

22. Aprotinin Procoagulant Fibrinolytic inhibitor Serine protease inhibitor (“serpin”) Streptokinase inhibitor

23. Argatroban Anticoagulant Direct thrombin inhibitor

24. L-asparaginase Antineoplastic Protein synthesis inhibitor

25. Aspirin (Acetylsalicylic acid, ASA) NSAID (acetylsalicylate) Analgesic, Anti-inflammatory Antipyretic, Antiplatelet Irreversible cyclooxygenase inhibitor

26. Atropine Anticholinergic Antimuscarinic Treatment for bradycardia, diarrhea, cholinesterase poisoning

27. Azathioprine Immunosuppressive Antineoplastic Antimetabolite (“pseudofeedback inhibition” of HGPRT and PRP)

28. Azithromycin Macrolide antibiotic Bacteriostatic protein synthesis inhibitor 50S ribosome Inhibits translocation

29. Aztreonam New  lactam antibiotic Monobactam

30. Baclofen Skeletal muscle relaxant Anxiolytic GABA B agonist

31. Bacitracin Antibiotic Cell wall synthesis inhibitor Topical, not a  lactam, Inhibits dephosphorylation of bactoprenol

32. Basiliximab Immunosuppressive Anti-CD25 (interleukin 2 receptor) Organ transplant (antirejection)

33. Benzathine penicillin G Penicillin antibiotic Cell wall synthesis inhibitor Inhibits peptidoglycan cross-linking Repository preparation

34. Benztropine Anticholinergic Antiparkinson Muscarinic receptor antagonist

35. Betamethasone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Not by inhalation

36. Bethanecol Cholinomimetic Muscarinic agonist Induces defecation and urination Bronchoconstrictor

37. Bleomycin Antineoplastic Natural product Antibiotic

38. Bivalirudin Anticoagulant Direct thrombin inhibitor

39. Bortezomib Antineoplastic Proteosome inhibitor

40. Bradykinin Inflammatory mediator Plasma, hypotension, pain

41. Bromocriptine Antiparkinson Dopamine (D 2 ) agonist Inhibits prolactin release

42. Brupropion Second generation antidepressant

43. Buprenorphine Opioid Partial agonist

44. Buspirone Sedative/hypnotic Anxiolytic

45. Busulfan Antineoplastic Alkylating agent

46. Butorphanol Opioid Analgesic  receptor partial agonist or antagonist

47. C3a, C5a Inflammatory mediators Anaphylatoxins Low molecular weight complement cleavage products

48. Carbamazepine Anticonvulsant

49. Carbenicillin Penicillin antibiotic Cell wall synthesis inhibitor Anti-pseudomonal penicillin Inhibits peptidoglycan cross-linking

50. Carbidopa Antiparkinson Peripheral dopa decarboxylase inhibitor

51. Carmustine (BCNU) Antineoplastic Alkylating Agent Nitrosourea

52. Cefaclor Cephalosporin antibiotic Cell wall synthesis inhibitor 2 nd generation Oral

53. Cefadroxil Cephalosporin antibiotic Cell wall synthesis inhibitor 1 st generation Oral

54. Cefepime Cephalosporin antibiotic Cell wall synthesis inhibitor 4 th generation CSF penetration

55. Cefotaxime Cephalosporin antibiotic Cell wall synthesis inhibitor 3 rd generation CSF penetration

56. Cefoxitin Cephalosporin antibiotic Cell wall synthesis inhibitor 2 nd generation

57. Ceftazidime Cephalosporin antibiotic Cell wall synthesis inhibitor 3 rd generation

58. Ceftriaxone Cephalosporin antibiotic Cell wall synthesis inhibitor 3 rd generation CSF penetration

59. Cefuroxime Cephalosporin antibiotic Cell wall synthesis inhibitor 2 nd generation CSF penetration

60. Celecoxib NSAID Anti-inflammatory Cyclooxygenase 2 (COX-2) inhibitor

61. Cephalexin Cephalosporin antibiotic Cell wall synthesis inhibitor 1 st generation Oral

62. Cephalosporins Antibiotics  lactam Cell wall synthesis inhibitors Inhibit cross-linking of peptidoglycan

63. Cephalothin Cephalosporin antibiotic Cell wall synthesis inhibitor 1 st generation Oral

64. Cetirizine Antihistamine H 1 antagonist Non-sedating

65. Chloral hydrate Sedative/Hypnotic General anaesthetic Acts on GABA A receptor complex Similar to barbiturates

66. Chloramphenicol Antibiotic Bacteriostatic protein synthesis inhibitor 50S ribosome Inhibits peptide bond formation

67. Chlordiazepoxide Sedative/hypnotic Anxiolytic Benodiazepine Acts on GABA A receptor complex

68. Chlorpheniramine Classical antihistamine H 1 antagonist

69. Chlorpromazine Antipsychotic Phenothiazine

70. Ciprofloxacin Fluoroquinolone antibiotic DNA replication inhibitor Inhibits bacterial DNA gyrase

71. Cisplatin Antineoplastic Miscellaneous Cross-linking agent

72. Clarithromycin Macrolide antibiotic Bacteriostatic protein synthesis inhibitor Antiulcer 50S ribosome Inhibits translocation

73. Clavulanic acid  -lactamase inhibitor Combined with antibacterials

74. Clindamycin Antibiotic Bacteriostatic protein synthesis inhibitor 50S ribosome Anaerobic infections

75. Clopidogrel Antiplatelet ADP receptor antagonist

76. Cloxacillin Penicillin antibiotic Cell wall synthesis inhibitor Penicillinase resistant penicillin Inhibits peptidoglycan cross-linking

77. Clozapine Antipsychotic

78. Cobalamin (cyanocobalamin, hydroxocobalamin) Vitamin Treatment for vitamin B12 deficiency

79. Cocaine Indirect sympathomimetic Drug of abuse Topical anaesthetic Stimulant Local anaesthetic

80. Codeine Opioid Analgesic Weak agonist

81. Cortisol (Hydrocortisone) Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid

82. Cyclophosphamide Antineoplastic Alkylating Agent Nitrogen mustard

83. Cycloserine Antibiotic Cell wall synthesis inhibitor Secondary TB drug Inhibits formation of Park nucleotide

84. Cyclosporine Immunosuppressive Antineoplastic Binds cyclophilin Inhibits calcineurin

85. Cytarabine (AraC) Antineoplastic Antimetabolite

86. Dacarbazine Antineoplastic Alkylating Agent

87. Daclizumab Immunosuppressive Anti-CD25 (interleukin 2 receptor) antibody Organ transplant (anti-rejection)

88. Dactinomycin Antineoplastic Natural product Antibiotic

89. Dalteparin Anticoagulant LMW Heparin ATIII activator

90. Dantrolene Skeletal muscle relaxant Ryanodine receptor antagonist Treatment for malignant hyperthermia

91. Dapsone Sulfone antibiotic Nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase Leprosy

92. Daunorubicin Antineoplastic Anthracycline antibiotic Natural product

93. Deprenyl/selegiline Antiparkinson Monoamine oxidase B inhibitor (MAO-I) Potentiates effects of L-Dopa

94. Desipramine Tricyclic antidepressant (TCA)

95. Desmopressin acetate Synthetic analogue of arginine vasopressin Used in treatment of bleeding disorders

96. Dexamethasone Adrenocorticosteroid Glucocorticoid Antineoplastic Antiemetic Anti-inflammatory steroid Not by inhalation

97. Dextromethorphan Opioid Antitussive

98. Diazepam Sedative/hypnotic Anxiolytic Anticonvulsant Benzodiazepine Acts on GABA A receptor complex

99. Diflunisal NSAID Analgesic, Anti-inflammatory Antipyretic Cyclooxygenase inhibitor

100. Diphenhydramine Classical antihistamine Antiemetic H 1 antagonist

101. Diphenoxylate docusate Antidiarrheal Opiate

102. Dipyridamole Antiplatelet Phosphodiesterase inhibitor (increases cAMP)

103. Doxorubicin Antineoplastic Anthracycline antibiotic Natural product

104. Doxycycline Tetracycline antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome Prevents aminoacyl tRNA attachment

105. Drotrecogin alfa (Activated Protein C) Anticoagulant Many actions Treatment for septic shock

106. Edrecolomab Antineoplastic Anti-17-1A antibody

107. Enflurane General anaesthetic Inhaled anaesthetic

108. Enoxaparin Anticoagulant LMW Heparin ATIII activator

109. Entacapone Antiparkinson Peripheral catechol-o- methyltransferase inhibitor

110. Ephedra (Ma Huang) Dietary supplement Amphetamine-like stimulant

111. Eptifibatide Antiplatelet GPIIb/IIIa antagonist

112. Erythromycin Macrolide antibiotic Bacteriostatic protein synthesis inhibitor 50S ribosome Inhibits translocation

113. Erythropoietin (EPO) Cytokine Primary regulator of RBC synthesis

114. Etanercept TNF inhibitor Tumor necrosis factor receptor + F c portion of IgG Used in rheumatoid arthritis

115. Ethanol Drug of abuse Sedative

116. Ethosuximide Anticonvulsant

117. Etomidate General anaesthetic Intravenous anaesthetic

118. Etoposide Antineoplastic Natural product Plant alkaloid

119. Fentanyl Opioid Analgesic  receptor agonist

120. Fexofenadine Antihistamine H 1 antagonist Non-sedating

121. Flumazenil Benzodiazepine antagonist Acts on GABA A receptor complex

122. 5-Fluorouracil Antineoplastic Antimetabolite Thymidylate synthase inhibitor

123. Fluoxetine Antidepressant Selective serotonin reuptake inhibitor (SSRI)

124. Flurazepam Sedative/Hypnotic Benzodiazepine Acts on GABA A receptor complex

125. Fluorinated Quinolones ciprofloxacin, norfloxacin Antibiotics DNA replication inhibitors Inhibit bacterial DNA gyrase

126. Folic acid Vitamin Treatment for folic acid deficiency

127. Gefitinib Antineoplastic Miscellaneous Tyrosine kinase inhibitor

128. Gemcitabine Antineoplastic Antimetabolite

129. Gemtuzumab Antineoplastic Anti-CD33 antibody

130. Gentamicin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation

131. Ginko biloba Dietary supplement Treatment of Alzheimer symptoms

132. Glutethimide Sedative/Hypnotic

133. Haloperidol Antipsychotic

134. Halothane General anaesthetic Inhaled anaesthetic

135. Heparin Anticoagulant ATIII activator

136. Heroin Drug of abuse Opioid

137. Hirudin Anticoagulant Direct thrombin inhibitor (DTI)

138. Histamine Inflammatory mediator Stored in mast cells and basophils

139. Hydrocortisone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid

140. 4-Hydroxycoumarin Oral anticoagulant Vitamin K synthesis inhibitor

141. Hydroxyurea Antineoplastic Miscellaneous Ribonucleotide reductase inhibitor

142. Hydroxyzine Classical antihistamine H 1 antagonist

143. Ibritumomab Antineoplastic Anti-CD20 antibody

144. Ibuprofen NSAID Analgesic, Anti-inflammatory Antipyretic Reversible cyclooxygenase inhibitor

145. Imatinib Antineoplastic Miscellaneous Tyrosine kinase inhibitor

146. Imipenem/Cilastatin New  lactam antibiotic Cilastatin inhibits a kidney dipeptidase that inactivates imipenem

147. Imipramine Indirect sympathomimetic Tricyclic antidepressant (TCA) Antimicturant

148. Indomethacin NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor Tocolytic Uterine relaxant

149. Infliximab TNF inhibitor Anti-TNF monoclonal antibody Treatment of IBD

150. Interferon alpha Antiviral for hepatitis Antineoplastic Cytokine Anti-angiogenesis

151. Interleukin 2 Cytokine Antineoplastic

152. Interleukin 11 Cytokine Antineoplastic (supporting agent)

153. Interleukin 12 Cytokine Antineoplastic (supporting agent)

154. Irinotecan Antineoplastic Natural product

155. Isoflurane General anaesthetic Inhaled anaesthetic

156. Kallidin Inflammatory mediator Plasma, hypotension, pain

157. Kava kava Dietary supplement Stress relief and treatment of insomnia

158. Ketamine General anaesthetic Drug of abuse Sedative

159. Ketoprofen NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

160. Lepirudin Anticoagulant Direct thrombin inhibitor (DTI)

161. Levodopa Antiparkinson Dopamine precursor

162. Leucovorin Antineoplastic (supporting agent) Folic acid analogue (used in methotrexate rescue)

163. Leukotriene B 4 (LTB 4 ) Inflammatory mediator Lipoxygenase product of arachidonate metabolism Chemotactic

164. Leukotrienes C 4, D 4, E 4 (LTC 4, LTD 4, LTE 4 ) Inflammatory mediators Cysteinyl leukotrienes Peptidyl leukotrienes SRS-A Lipoxygenase products of arachidonate metabolism

165. Lidocaine Class I antiarrhythmic Local anaesthetic Na + channel blocker (activated and inactivated channels)

166. Linezolid Oxazolidinone antibiotic Protein synthesis inhibitor 50S ribosomal subunit

167. Lithium Antidepressant Used to treat manic/depressive disorder

168. Lomustine (CCNU) Antineoplastic Alkylating Agent Nitrosourea

169. Loperamide Antidiarrheal Opiate

170. Loratidine Antihistamine H 1 antagonist Non-sedating

171. Lorazepam Anxiolytic Anticonvulsant Benzodiazepine Acts on GABA A receptor complex

172. Lysergic acid diethylamide (LSD) Drug of abuse Hallucinogen

173. Macrolides erythromycin, azithromycin, clarithromycin Antibiotics Bacteriostatic protein synthesis inhibitors 50S ribosome

174. Marijuana Drug of abuse Cannabinoid

175. Mechlorethamine Antineoplastic Alkylating Agent Nitrogen mustard

176. Meclofenamate NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

177. Melphalan Antineoplastic Alkylating Agent Nitrogen mustard

178. Meperidine Opioid analgesic  receptor agonist

179. Mepivacaine Local anaesthetic

180. Meprobamate Sedative/hypnotic Anxiolytic

181. 6-Mercaptopurine Antineoplastic Antimetabolite (“pseudofeedback inhibition” of HGPRT and PRP – purine synthesis)

182. Mesna Antineoplastic (supporting agent) Prevent hemorrhagic cystitis due to cyclophosphamide

183. Methicillin Penicillin antibiotic Cell wall synthesis inhibitor Pencillinase resistant penicillin Inhibits peptidoglycan cross-linking

184. Methotrexate Immunosuppressive Antineoplastic Folic acid antagonist Dihydrofolate reductase inhibitor

185. Methylprednisolone Adrenocorticosteroid Glucocorticoid Anti-inflammatory steroid Not by inhalation

186. Metronidazole Antibiotic Antiparasitic Antiulcer Anaerobes Reduction leads to intermediates that damage DNA

187. Minocycline Tetracycline antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome Prevents aminoacyl tRNA attachment

188. Mitomycin C Antineoplastic Natural product Antibiotic

189. Metamphetamine Drug of abuse Stimulant

190. Methadone Opioid  receptor agonist

191. Montelukast Leukotriene inhibitor LTR1 and LTD4 antagonist Asthma treatment

192. Morphine Opioid Analgesic  receptor agonist

193. Muromonab-CD3 Immunosuppressive Mouse monoclonal anti-CD3 antibody Organ transplant (anti-rejection)

194. Mycophenolate Immunosuppressive Inhibits inosine monophosphate dehydrogenase activity

195. Nalbuphine Opioid antagonist  receptor antagonist

196. Nalmefene Opioid antagonist

197. Nalorphine Opioid antagonist

198. Naloxone Opioid antagonist

199. Naltrexone Opioid antagonist

200. Naproxen NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

201. Nafcillin Penicillin antibiotic Cell wall synthesis inhibitor Penicillinase resistant penicillin Inhibits peptidoglycan cross-linking

202. Neomycin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation Topical

203. Neostigmine Anticholinesterase Vasodilator Treatment for myaesthenia gravis Promotes defecation and urination Bronchoconstrictor

204. Netilmicin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation

205. Nicotine Cholinomimetic Drug of abuse Nicotinic receptor agonist (skeletal muscle contraction) Stimulant Smoking cessation medication

206. Nitrous oxide General anaesthetic Inhaled anaesthetic

207. Non-steroidal Anti-inflammatory Drugs (NSAIDs) Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitors

208. Norfloxacin Fluoroquinolone antibiotic DNA replication inhibitor Inhibits bacterial DNA gyrase

209. Nortriptyline Tricyclic antidepressant (TCA)

210. Omalizumab Anti-asthma Anti-IgE antibody

211. Oxacillin Penicillin antibiotic Cell wall synthesis inhibitor Pencillinase resistant penicillin Inhibits peptidoglycan cross-linking

212. Oxazepam Sedative/hypnotic Anxiolytic Benzodiazepine Acts on GABA A receptor complex

213. Oxybutinin Anticholinergic Muscarinic receptor antagonist Prevents urination

214. Oxycodone Analgesic Opioid agonist

215. Oxytetracycline Tetracycline antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome Prevents aminoacyl tRNA attachment

216. Paclitaxel Antineoplastic Natural product Plant alkaloid (taxane)

217. Palivizumab Antiviral Monoclonal antibody against the surface of respiratory syncytial virus

218. Para-aminosalicylic acid Antibiotic Nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase Secondary TB drug

219. Paraldehyde Sedative/Hypnotic

220. Penicillins  lactam antibiotics Cell wall synthesis inhibitors Inhibit cross-linking of peptidoglycan

221. Penicillin G Penicillin antibiotic Cell wall synthesis inhibitor Acid labile Inhibits peptidoglycan cross-linking

222. Penicillin V Penicillin antibiotic Cell wall synthesis inhibitor More acid resistant than Penicillin G Inhibits peptidoglycan cross-linking

223. Pentazocine Opioid analgesic  receptor partial agonist or antagonist

224. Pentobarbital Sedative/Hypnotic Barbiturate

225. Pentostatin Antineoplastic Miscellaneous Enzyme inhibitor (blocks purine synthesis)

226. Phencyclidine (PCP) Drug of abuse Hallucinogen

227. Phenobarbital Sedative/Hypnotic Anticonvulsant Barbiturate

228. Phenytoin Anticonvulsant Class I antiarrhythmic Na + channel blocker (inactivated channels)

229. Phytonadione Vitamin K Warfarin antagonist

230. Piperacillin Penicillin antibiotic Cell wall synthesis inhibitor Anti-pseudomonal penicillin Inhibits peptidoglycan cross-linking

231. Piroxicam NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

232. Platelet Activating Factor (PAF) Inflammatory mediator Lipid Hypotensive

233. Polymyxin B Antibiotic Disrupts gram negative cell membrane Binds phosphatidylethanolamine Bactericidal

234. Pramipexole Antiparkinson Dopamine agonist (non-ergot)

235. Prednisone Adrenocorticosteroid Glucocorticoid Antineoplastic Anti-inflammatory Not by inhalation

236. Primidone Anticonvulsant

237. Probenecid Uricosuric Adjunct in penicillin therapy

238. Procaine Local anaesthetic

239. Procaine Penicillin G Penicillin antibiotic Cell wall synthesis inhibitor Repository preparation Inhibits peptidoglycan cross-linking

240. Procarbazine Antineoplastic Miscellaneous Probably acts as alkylating agent

241. Promethazine Classical antihistamine Antipsychotic Antiemetic H 1 antagonist

242. Propofol General anaesthetic Intravenous anaesthetic

243. Prostaglandin D 2 (PGD 2 ) Bronchoconstrictor Cyclooxygenase product of arachidonate metabolism

244. Prostaglandin E 2 (PGE 2 ) Dinoprostone (Dinoprost) Oxytocic prostaglandin Inflammatory mediator Cyclooxygenase product of arachidonate metabolism Uterine stimulant Cervical ripener

245. Prostaglandin F 2 (PGF 2 ) Inflammatory mediator Cyclooxygenase product of arachidonate metabolism

246. Prostaglandin I 2 (PGI 2 ) Inflammatory mediator Inhibits platelet aggregation Cyclooxygenase product of arachidonate metabolism Prostacyclin

247. Protamine Sulfate Heparin antagonist

248. Quinopristin/Dalfopristin Streptogramin antibiotic Protein synthesis inhibitor 50S ribosomal subunit

249. Resperidone Antipsychotic

250. Rifampin Antibiotic Nucleic acid synthesis inhibitor Inhibits DNA dependent RNA polymerase Major drug for TB

251. Rituxumab Antineoplastic Anti-CD20 antibody

252. Rofecoxib NSAID Anti-inflammatory Cyclooxygenase 2 (COX-2) inhibitor

253. Ropinirole Antiparkinson Dopamine agonist (non-ergot)

254. Sargramostim (GM-CSF) Colony stimulating factor WBC (granulocyte and macrophage) stimulant

255. Sertraline Antidepressant Selective serotonin reuptake inhibitor (SSRI)

256. Sildenafil Vasodilator Promotes erection

257. Silver sulfadiazine Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase Topical

258. Sirolimus Immunosuppressive Binds FKBP, inhibits mTOR (mammalian kinase target of rapamycin) & cell cycle progression Rapamycin

259. Spectinomycin Antibiotic Bacteriostatic protein synthesis inhibitor 30S ribosome

260. St. John’s Wort Dietary supplement Antidepressant

261. Streptokinase Thrombolytic

262. Streptomycin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation

263. Sufentanil Opioid General anaesthetic Intravenous anaesthetic

264. Sulfacetamide Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase Topical

265. Sulfadoxine Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Dihydropteroate synthetase inhibitor

266. Sulfamethoxazole Sulfonamide antibiotic Microbial nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase

267. Sulfisoxazole Sulfonamide antibiotic Nucleic acid and protein synthesis inhibitor Inhibits dihydropteroate synthetase

268. Sulfonamides Antibiotics Nucleic acid and protein synthesis inhibitors Inhibit dihydropteroate synthetase

269. Sulindac NSAID Analgesic, Anti-inflammatory, Antipyretic Cyclooxygenase inhibitor

270. Tacrolimus Immunosuppressive Antineoplastic Binds FKBP (FK506 binding protein) Inhibits calcineurin

271. Temazepam Sedative/Hypnotic Benzodiazepine Acts on GABA A receptor complex

272. Tetracaine Local anaesthetic

273. Tetracycline Antibiotic Bacteriostatic protein synthesis inhibitor Antiulcer 30S ribosome Prevents aminoacyl tRNA attachment

274. Thalidomide Antineoplastic Leprosy treatment Anti-angiogenic Anti-TNF 

275. 6-Thioguanine Antineoplastic Antimetabolite (“pseudofeedback inhibition” of HGPRT and PRP – purine synthesis)

276. Thiopental General anaesthetic Ultra-short-acting barbiturate

277. Thioridazine Antipsychotic Phenothiazine

278. Thiotepa Antineoplastic Alkylating agent

279. Thiothixene Antipsychotic

280. Thromboxane A 2 (TXA 2 ) Autacoid Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism

281. Ticlopidine Antiplatelet ADP receptor antagonist

282. Ticarcillin Penicillin antibiotic Cell wall synthesis inhibitor Anti-pseudomonal penicillin Inhibits peptidoglycan cross-linking

283. Tissue plasminogen activators Thrombolytics alteplase, reteplase, tenecteplase

284. Tobramycin Aminoglycoside antibiotic Bactericidal protein synthesis inhibitor 30S ribosome Freezes initiation

285. Tolterodine Anticholinergic Muscarinic receptor antagonist Prevents urination

286. Tositumomab Antineoplastic Anti-CD20 antibody

287. Tranylcypromine Antidepressant Monoamine oxidase inhibitor (MAO-I)

288. Trastuzumab Antineoplastic Anti-HER2 antibody

289. Triazolam Sedative/Hypnotic Benzodiazepine Acts on GABA A receptor complex

290. Trifluoperazine Antipsychotic Phenothiazine

291. Trihexyphenidyl Antiparkinson Antimuscarinic

292. Trimethoprim Antibiotic Protein and nucleic acid synthesis inhibitor Folic acid antagonist Inhibits bacterial dihydrofolate reductase

293. Tripelennamine Classical antihistamine H 1 antagonist

294. Tumor necrosis factor  Cytokine Antineoplastic

295. Urokinase Thrombolytic

296. Valproic acid Anticonvulsant

297. Vancomycin Antibiotic Inhibits cell wall synthesis Not a  lactam

298. Vigabatrin Anticonvulsant Irreversible GABA aminotransferase inhibitor

299. Vinblastine Antineoplastic Vinca alkaloid Natural product

300. Vincristine Antineoplastic Vinca alkaloid Natural product

301. Warfarin Anticoagulant Vitamin K synthesis inhibitor

302. Zafirlukast Leukotriene inhibitor LTR 1 and LTD 4 antagonist Asthma treatment

303. Zileuton Leukotriene inhibitor 5-lipoxygenase inhibitor Used in asthma

304. Zolpidem Sedative/Hypnotic Non-benzodiazepine