1. Interpenetrating Networks for Delivery Systems Client: Professor W. John Kao, School of Pharmacy & Department of Biomedical Engineering Advisor: Professor Naomi Chesler, Department of Biomedical Engineering Ashley Huth Claire Flanagan Adam Rieves Jon Sass

2. Overview Background Information Interpenetrating Networks (IPNs) Competing Products Past Semester Problem Statement Design Requirements Proposed Designs Future Work Questions

3. Problem Statement To design a novel delivery mechanism to reconstitute the components of an interpenetrating network (IPN).

4. Background: IPNs *Kao, W.J. What is an IPN? A bioactive wound dressing for large surface area wounds IPN Conventional Dressings Irregular Wound

5. Background: IPNs Kao, W.J. Solution (drugs + matrix component) Covalently Linked Therapeutic(s) and/or Cell Adhesion Ligands Soluble Therapeutic(s) Biodegradable Gelatin Backbone PEG- diacrylate (2-3.4 kDa ) in situ UV curing IPNs are composed of multiple components

6. Clinical Application Benefits –Biocompatible –Moist healing environment –Conforms to irregular wounds –Covers large surface area wounds –Delivers drug cocktails Issues –Heat –Uneven administration –Lengthy application process

7. Current Administration Technique Ingredients/ drug(s) in single container Mix 1 1 Cover 5 5 Heat 2 2 3 3 Inject Syringe is use to administer solution 4 4 Cure in 30 sec to obtain a rubbery film 6 6 Sustained Release while the IPN biodegrades Day 7 Day 3 Day 1 7 7 Clean *Kao, W.J Components pegDA Gelatin Photoinitator Water

8. Last Semester Focused on optimizing IPN solution composition –Gelatin dissolution impacts efficacy & administration of IPNs – Integrated laboratory & design-based research Developed IPN recipe Modified IPN administration This Semester Administration technique Product packaging Further laboratory research

9. Design Requirements Minimal preparation and effort required to administer the IPN Compartmentalization Even spray pattern Uniform solution Straightforward mixing procedure Disposable Can be sterilized Low-cost Few parts

10. Competing Products Duoject Medical Systems Inc. –Inter-Vial Debiotech –Clip’n’ject U-Mix –Travel Bottle Hansplast –Spray Bandage

11. Design 1: Syringe Liquid in plunger Powder stored in barrel Mechanism to release liquid into powder Hand mixing Hand powered delivery Luer-Lock spray tip

12. Design 1: Syringe Pros – All in one packaging –Easy application –Controllable spray rate Cons –Custom manufacturing required –Moving parts

13. Design 2: Pressurized Bottle Manual pressure vacuum Unique cap design –Facilitates stirring mechanism Perforated seal

14. Design 3: Pressurized Bottle Pros –Incorporates mixing mechanism –Provides slow release of photo-initiator Cons –Laborious application technique –Non-standard parts

15. Design 1: Spray Bottle Threaded straw Blades puncture inner container Single pump, single spray Includes mixing mechanism

16. Design 3: Spray Bottle Pros –Incorporates mixing mechanism –Provides slow release of photo-initiator Cons –Laborious application technique –Non-standard parts

17. Design Matrix

18. Future Work Test cold-water soluble gelatin Develop-Manufacture-Test prototype Research photoinitiators Continue patent search