1. Slides last updated: October 2013

2. There are two main types of lung cancer 1 1.Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, April 2013, accessed on 15/09/2013.

3. NSCLC (85.3% of lung cancer) Lung Cancer (100%) Other NSCLC (20.2% of lung cancer) Squamous cell carcinoma (21.4% of lung cancer) Adenocarcinoma (40.1% of lung cancer) 1.Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, April 2013, accessed on 15/09/2013. NSCLC can be further divided into different sub-types 1

4. NSCLC: Adenocarcinoma Adenocarcinoma Adenocarcinoma lesions are usually peripherally located 2 Most frequent in women and non-smokers 2 Some patients have EGFR/ErbB1 mutations; these patients require a specific diagnosis and treatment approach 3 40.1% 1 1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, April 2013, accessed on 15/09/2013. 2. Heighway J & Betticher DC. Atlas Genet Cytogenet Oncol Haematol. February 2004. 3. Vijayalakshmi R, et al. Indian J Surg Oncol 2011;2:178 ‒ 188.

5. NSCLC: Squamous cell carcinoma Squamous Cell Carcinoma 2 Squamous Cell Carcinoma lesions are generally centrally located, near bronchi Tends to spread locally Closely correlated with smoking 21.4% 1 1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, April 2013, accessed on 15/09/2013. 2. Heighway J & Betticher DC. Atlas Genet Cytogenet Oncol Haematol. February 2004.

6. NSCLC: Large cell carcinoma Large Cell Carcinoma Comprised of undifferentiated cells 2 Lesions are usually peripherally located but can occur anywhere 2 High tendency to metastasize 2 2.6% 1 1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, April 2013, accessed on 15/09/2013. 2. Heighway J & Betticher DC. Atlas Genet Cytogenet Oncol Haematol. February 2004.

7. NSCLC: Other Other, including Not Otherwise Specified (NOS) or Unknown A classification of NOS or unknown is usually due to ineffective sampling and examination 2 This classification is expected to decline in use due to more accurate biopsies and advances in immunohistochemistry and biomarker testing 2 20.2% 1 1. Howlader N, Noone AM, Krapcho M, et al. (eds). SEER Cancer Statistics Review, 1975-2010, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2010/, based on November 2012 SEER data submission, posted to the SEER web site, April 2013, accessed on 15/09/2013. 2. Righi L, Graziano P, Fornari A, et al. Cancer 2011;117:3416 ‒ 3423.