1. Meiosis Chapter 8 Part II

2. Octopus Sex Male reaches under his mantle with tentacle, removes packet of sperm, and insert it into females egg chamber Male reaches under his mantle with tentacle, removes packet of sperm, and insert it into females egg chamber Eggs are fertilized and give rise to new octopuses Eggs are fertilized and give rise to new octopuses

3. Limpet Sex Limpet Sex Larva can become adult of either sex Larva can become adult of either sex Depends on whether other limpets are present and what their sex is Depends on whether other limpets are present and what their sex is Adults can change sex in response to new arrivals Adults can change sex in response to new arrivals

5. Slipper snails Hermaphroditic Hermaphroditic Stacked on top of each other Stacked on top of each other Young are always male Young are always male Can stay male or change to female Can stay male or change to female Cannot go back to male Cannot go back to male

7. Sexual Reproduction Chromosomes are duplicated in germ cells Chromosomes are duplicated in germ cells Germ cells undergo meiosis and cytoplasmic division Germ cells undergo meiosis and cytoplasmic division Cellular descendents of germ cells become gametes Cellular descendents of germ cells become gametes Gametes meet at fertilization Gametes meet at fertilization

8. Meiosis

9. Asexual Reproduction Single parent produces offspring Single parent produces offspring All offspring are genetically identical to one another and to parent All offspring are genetically identical to one another and to parent

10. Sexual Reproduction Sexual Reproduction Involves Involves Meiosis Meiosis Gamete production Gamete production Fertilization Fertilization Produces genetic variation among offspring Produces genetic variation among offspring

11. Homologous Chromosomes Carry Different Alleles Cell has two of each chromosome Cell has two of each chromosome One chromosome in each pair from mother, other from father One chromosome in each pair from mother, other from father Paternal and maternal chromosomes carry different alleles Paternal and maternal chromosomes carry different alleles

12. Alleles- Different forms of a gene

13. What is a gene? Chemical factors that determine traits Chemical factors that determine traits

14. Sexual Reproduction Shuffles Alleles Through sexual reproduction, offspring inherit new combinations of alleles, which leads to variations in traits Through sexual reproduction, offspring inherit new combinations of alleles, which leads to variations in traits This variation in traits is the basis for evolutionary change This variation in traits is the basis for evolutionary change

15. Gamete Formation Gamete Formation Gametes are sex cells (sperm, eggs) Gametes are sex cells (sperm, eggs) Arise from germ cells Arise from germ cells testes ovaries anther ovary

18. Chromosome Number Sum total of chromosomes in a cell Sum total of chromosomes in a cell Germ cells are diploid (2n) Germ cells are diploid (2n) Gametes are haploid (n) Gametes are haploid (n) Meiosis halves chromosome number Meiosis halves chromosome number

19. Meiosis: Two Divisions Two consecutive nuclear divisions Two consecutive nuclear divisions Meiosis I Meiosis I Meiosis II Meiosis II DNA is NOT duplicated between divisions DNA is NOT duplicated between divisions Four haploid nuclei are formed Four haploid nuclei are formed

20. Meiosis I Each homologue in the cell pairs with its partner, then the partners separate

21. Meiosis II The two sister chromatids of each duplicated chromosome are separated from each other The two sister chromatids of each duplicated chromosome are separated from each other one chromosome (duplicated) two chromosomes (unduplicated)

22. Stages of Meiosis Stages of Meiosis Meiosis I Prophase I Prophase I Metaphase I Metaphase I Anaphase I Anaphase I Telophase I Telophase I Meiosis II Prophase II Metaphase II Anaphase II Telophase II

23. Meiosis I - Stages Prophase IMetaphase IAnaphase ITelophase I

24. 46 92

25. 46x2 23x4

28. Section 11-4 Figure 11-15 Meiosis Meiosis I

29. Meiosis II Meiosis I results in two haploid (N) daughter cells, each with half the number of chromosomes as the original. Prophase IIMetaphase IIAnaphase IITelophase II The chromosomes line up in a similar way to the metaphase stage of mitosis. The sister chromatids separate and move toward opposite ends of the cell. Meiosis II results in four haploid (N) daughter cells. Section 11-4 Figure 11-17 Meiosis II

30. Prophase I Each duplicated, condensed chromosome pairs with its homologue Each duplicated, condensed chromosome pairs with its homologue Homologues swap segments Homologues swap segments Each chromosome becomes attached to microtubules of newly forming spindle Each chromosome becomes attached to microtubules of newly forming spindle

31. Crossing-Over

34. Crossing Over Each chromosome becomes zippered to its homologue All four chromatids are closely aligned Non-sister chromosomes exchange segments

35. Effect of Crossing Over After crossing over, each chromosome contains both maternal and parental segments After crossing over, each chromosome contains both maternal and parental segments Creates new allele combinations in offspring Creates new allele combinations in offspring

36. Metaphase I Chromosomes are pushed and pulled into the middle of cell Chromosomes are pushed and pulled into the middle of cell Sister chromatids of one homologue orient toward one pole, and those of other homologue toward opposite pole Sister chromatids of one homologue orient toward one pole, and those of other homologue toward opposite pole The spindle is now fully formed The spindle is now fully formed

37. Anaphase I Homologous chromosomes segregate from each other Homologous chromosomes segregate from each other The sister chromatids of each chromosome remain attached The sister chromatids of each chromosome remain attached

38. Telophase I The chromosomes arrive at opposite poles The chromosomes arrive at opposite poles The cytoplasm divides The cytoplasm divides There are now two haploid cells There are now two haploid cells This completes Meiosis I This completes Meiosis I

39. Meiosis II - Stages Prophase IIMetaphase IIAnaphase IITelophase II

40. Prophase II Microtubules attach to the kinetochores of the duplicated chromosomes Microtubules attach to the kinetochores of the duplicated chromosomes Motor proteins drive the movement of chromosomes toward the spindles equator Motor proteins drive the movement of chromosomes toward the spindles equator

41. Metaphase II All of the duplicated chromosomes are lined up at the spindle equator, midway between the poles All of the duplicated chromosomes are lined up at the spindle equator, midway between the poles

42. Anaphase II Sister chromatids separate to become independent chromosomes Sister chromatids separate to become independent chromosomes Motor proteins interact with microtubules to move the separated chromosomes to opposite poles Motor proteins interact with microtubules to move the separated chromosomes to opposite poles

43. Telophase II The chromosomes arrive at opposite ends of the cell The chromosomes arrive at opposite ends of the cell A nuclear envelope forms around each set of chromosomes A nuclear envelope forms around each set of chromosomes The cytoplasm divides The cytoplasm divides There are now four haploid cells There are now four haploid cells

44. Random Alignment During transition between prophase I and metaphase I, microtubules from spindle poles attach to kinetochores of chromosomes During transition between prophase I and metaphase I, microtubules from spindle poles attach to kinetochores of chromosomes Initial contacts between microtubules and chromosomes are random Initial contacts between microtubules and chromosomes are random

45. Random Alignment Either the maternal or paternal member of a homologous pair can end up at either pole Either the maternal or paternal member of a homologous pair can end up at either pole The chromosomes in a gamete are a mix of chromosomes from the two parents The chromosomes in a gamete are a mix of chromosomes from the two parents

46. Possible Chromosome Combinations As a result of random alignment, the number of possible combinations of chromosomes in a gamete is: 2 n (n is number of chromosome types)

47. Possible Chromosome Combinations or 123

48. Plant Life Cycle multicelled sporophyte multicelled gametophytes zygote gametes spores meiosisfertilization mitosis Diploid Haploid

49. Animal Life Cycle multicelled body gametes zygote meiosisfertilization mitosis Diploid Haploid

50. Spermatogenesis Growth Mitosis I, Cytoplasmic division Meiosis II, Cytoplasmic division spermatids (haploid) secondary spermatocytes (haploid) primary spermatocyte (diploid) spermato- gonium (diploid male reproductive cell)

51. Oogenesis Growth Mitosis I, Cytoplasmic division Meiosis II, Cytoplasmic division ovum (haploid) primary oocyte (diploid) oogonium (diploid reproductive cell) secondary oocyte haploid) first polar body haploid) three polar bodies haploid)

52. Fertilization Male and female gametes unite and nuclei fuse Male and female gametes unite and nuclei fuse Fusion of two haploid nuclei produces diploid nucleus in the zygote Fusion of two haploid nuclei produces diploid nucleus in the zygote Which two gametes unite is random Which two gametes unite is random Adds to variation among offspring Adds to variation among offspring

53. Factors Contributing to Variation Among Offspring Crossing over during prophase I Crossing over during prophase I Random alignment of chromosomes at metaphase I Random alignment of chromosomes at metaphase I Random combination of gametes at fertilization Random combination of gametes at fertilization

54. Mitosis Functions Functions Asexual reproduction Asexual reproduction Growth, repair Growth, repair Occurs in somatic cells Occurs in somatic cells Produces clones Produces clones Mitosis & Meiosis Compared Mitosis & Meiosis Compared Meiosis Function Sexual reproduction Occurs in germ cells Produces variable offspring

55. Prophase vs. Prophase I Prophase (Mitosis) Prophase (Mitosis) Homologous pairs do not interact with each other Homologous pairs do not interact with each other Prophase I (Meiosis) Prophase I (Meiosis) Homologous pairs become zippered together and crossing over occurs Homologous pairs become zippered together and crossing over occurs

56. Anaphase, Anaphase I, and Anaphase II Anaphase, Anaphase I, and Anaphase II Anaphase I (Meiosis) Anaphase I (Meiosis) Homologous chromosomes are separated from each other Homologous chromosomes are separated from each other Anaphase/Anaphase II (Mitosis/Meiosis) Anaphase/Anaphase II (Mitosis/Meiosis) Sister chromatids of a chromosome are separated from each other Sister chromatids of a chromosome are separated from each other

57. Results of Mitosis and Meiosis Mitosis Mitosis Two diploid cells produced Two diploid cells produced Each identical to parent Each identical to parent Meiosis Meiosis Four haploid cells produced Four haploid cells produced Differ from parent and one another Differ from parent and one another

58. Pre-Natal Tests - help to determine if an at risk baby is healthy

59. Sex chromosomes Human Karyotype

60. Sex Chromosomes

61. Down Syndrome (trisomy 21), 47,XY,+21. 47: the total number of chromosomes (46 is normal). XY: the sex chromosomes (male). +21: designates the extra chromosome as a 21.

62. Klinefelters Syndrome 47, XXY

63. Turners Syndrome Only one complete X Only one complete X The second could also be incomplete The second could also be incomplete In almost all cases, unable to repro. Or menstruate In almost all cases, unable to repro. Or menstruate

64. Hermaphrodite XX/XY or XO XX/XY or XO 350-400 Known cases 350-400 Known cases

65. Gene Therapy - an absent or faulty gene is replaced by a working gene Has not been very successful