1. Common Worm Infestations in Children Dr Nishant Verma Department of Pediatrics

2. Burden of disease Neglected Tropical Diseases (NTDs) are the most common diseases of the world’s poor. These diseases disable and debilitate one in six people worldwide, including half a billion children. The 7 Most Common NTDs 1.Ascariasis 2.Hookworm 3.Lymphatic Filariasis 4.Onchocerciasis 5.Schistosomiasis 6.Trichuriasis 7.Trachoma

3. For just 50 cents, treatment can be provided to a person against seven NTDs for an entire year The 7 Most Common NTDs 1.Ascariasis 2.Hookworm 3.Lymphatic Filariasis 4.Onchocerciasis 5.Schistosomiasis 6.Trichuriasis 7.Trachoma

4. Ascaris lumbricoides Enterobius vermicularis Hook worm Trichuris trichiura Brugia malayi Wuchereria bancrofti Schistosoma Clonorchis Fasciola hepatica Taenia solium Taenia saginata Echinococcus Diphyllobothrium latum

5. Ascaris lumbricoides – Life cycle

6. C/F – Abdominal Pain, distension, vomiting Passage of worms in stool/vomitus Obstruction – Pulmonary: Loeffler syndrome – Growth failure Ascaris lumbricoides

7. Diagnosis – Eggs in stool sample – Worms in stool / vomitus – Imaging Treatment Ascaris lumbricoides Albendazole 400 mg Once (Taken with food) Other options Mebendazole Ivermectin Nitazoxanide

8. Enterobius vermicularis (Pin Worm) Peri-anal itching More at night

9. Diagnosis – Stool microsopy: not useful – Eggs can be demonstrated in peri anal swabs collected early morning – Sticky tape on a tongue depressor Treatment Enterobius vermicularis (Pin Worm) Albendazole 400 mg Once, repeat in 2wk Other options Mebendazole Pyrantel Treat entire family

10. Hook worm Ancylostoma duodenale / Necator americanus

11. Hook worm C/F – Ground itch – Abdominal pain, anorexia – Iron deficiency anemia – Hypoproteinemia Dx – Stool microscopy – Peripheral smear Treatment Albendazole 400 mg Once Other options Mebendazole Pyrantel Oral Iron therapy

12. Filariasis Wuchereria bancrofti, Brugia malayi, B. timori

13. Filariasis C/F – Most remain asymptomatic – IP: 8-16months – Episodes of Fever, lymphangitis, lymphadenitis – Last for 7-10d – 8-10 episodes/yr – Tropical Pulmonary Eosinophilia – Chronic stage: Lymphatic obstruction > 25yr age Lymphedema / Elephantiasis

14. Filariasis Dx – Mf identified in thick blood film – Nocturnal periodicity – Adult worm in LN biopsy Treatment Prevention Di –Ethyl-Carbamazine (DEC) 6mg/kg /day q8hr for 12 days Other options Single dose Ivermectin Ivermectin + Albendazole

15. Echinococcosis Cystic EchinococcosisAlveolar Echinococcosis Echinococcus granulosus, E. multilocularis

16. Echinococcosis C/F – Site and mass effect of the cyst – Rupture: fever, anaphylaxis

17. Echinococcosis Diagnosis – Imaging – Serology: Sensitive, not specific Treatment Surgical Complete removal USG/CT guided Percutaneous Aspiration, Instillation of hypertonic saline, Reaspiration (PAIR) Medical Albendazole 15mg/kg/day for 2wk May require repeated courses Monitor by serial USG

18. Taeniasis Pork Tapeworm Beef Tapeworm Taenia solium Taenia saginata

19. Taeniasis

20. C/F – Mild epigastric discomfort, nausea, flatulence, diarrhea Dx – Microscopic identification of eggs and proglottids in feces Treatment Praziquantel 5-10mg/kg single dose Alternative option Niclosamide 50mg/kg single dose

21. Cysticercosis

24. Neurocysticercosis C/F – Depends on site and number of cysts – Seizures, headache – Cysticercal encephalitis Dx – Neuroimaging – Diff from tuberculoma

25. Neurocysticercosis Treatment – Anticonvulsants – Albendazole If active lesions on imaging 15mg/kg/day for 7-28 days Adjunctive steroids – Relative C/I for albendazole Intraocular cysts Intraventricular cysts Spinal cysts Prevention