1. Single Fiber Polymorphism in Skeletal Muscles: A Case Example from the Lobster Scott Medler

2. Wolfe, 1985 Cell Ultrastructure

3. Guyton and Hall 1996 Textbook of Medical Physiology 9th Ed.

6. Guyton and Hall 1996 Textbook of Medical Physiology 9th Ed.

7. Guyton and Hall 1996 Textbook of Medical Physiology 9th Ed.

15. S 1 /S 2 MHC expression

16. Tm expression vs. MHC expression (mRNA)

17. TnT 3 protein vs. S1/S2 MHC mRNA

18. TnI 3 protein vs. S1/S2 MHC mRNA

19. TnI 2 protein vs. S1/S2 MHC mRNA

20. S 2 fibersS 1 fibers S 2 MHC S 1 MHC TnT 1 TnT 3 CONTINUUM OF ISOFORM EXPRESSION = high expression = low expression TnI 3 TnI 2 S 1 Tm S 2 Tm

22. Immediate Research Focus: Single fiber polymorphism in lobsters Developmental changes in fiber phenotype Innervation pattern and fiber phenotype Effects of electrical stimulation on fiber phenotype Mechanical measurements from single fibers

23. Long Term Research Interests: Single Fiber Polymorphism in Mammals Scaling Effects on Cellular/Molecular Organization of Muscles Physiology of Avian Flight Muscles

24. Acknowledgements: National Institutes of Health: Postdoctoral fellowship AR 08597-01A1 to S. Medler National Science Foundation: IBN-0077422 to D.L. Mykles Dr. D.L. Mykles Colorado State University Travis Lilley Colorado State University