1. Arista Biologicals Inc. Denise C. Glascock Sales & Marketing Manager

2. Background Founded in 1993 by Dr. John Colanduoni Established originally to provide biological reagents to diagnostic kit manufacturers. Now supplies all necessary components to produce rapid diagnostic assays as well as the technology required.

3. Mission Statement Our mission is to make available to our customers, whether they are in the start-up phase or established, the highest quality reagents for the lateral flow industry. We believe this policy will open the market to people in underdeveloped countries, and will help bring them the level of healthcare that is now only accessible to the more developed countries.

4. IVD Market & Rapid Assay Market Overview Arista Biologicals Inc.

5. History Immunological interactions have been used for In-Vitro Diagnostic purposes for many years Started with Agglutination Assays Immunoassays became popular with the development on EIA and ELISA technology EIAs and ELISAs are still the backbone of clinical immunodiagnostics Arista Biologicals Inc.

6. History Cont… Problem EIAs and ELISAs require a lot of time, sophisticated equipment and highly trained personnel. The Primary Issue was Cost Solution Membrane Based Assays Arista Biologicals Inc.

7. History Cont… Specific Immunoadsorption Dipstick Devices Immunoconcentraion Devices Flow Through Immunochromatography Devices Lateral Flow Arista Biologicals Inc.

8. History Cont… In the mid-1970’s initial Immunoassays on membranes were developed as variations of Dot Blots. The membrane acted as a solid phase with a surface area for the immobilization of one of the reactants. The primary application was in research, not clinical diagnostics. This was the precursor to the Immunoconcentraion/Flow-Through Arista Biologicals Inc.

9. History Cont… Specific Immunoadsorption/Dipstick Devices In the mid-1970’s Dip-Stick tests were developed for routine chemistry application. This technology has been adapted for environmental testing. Arista Biologicals Inc.

10. History Cont… Immunoconcentration/Flow-Through Devices In the early-1980’s membranes were first utilized in immunoassay devices in a vertical flow-through configuration that exploited the advantages of using membrane for more than its ability to act as a solid phase for immobilization. This configuration reduced incubation times by a factor of 10. Allows for the manufacture of simple, rapid, disposable immunoassay devices that can be used in the home or in other remote testing sites. Still requires multiple steps. Arista Biologicals Inc.

11. History Cont… Immunochromatography/Lateral Flow Devices In the late-1980’s a second generation of immunoassay devices was developed. Key to Lateral Flow performance is the manufacture of large nitrocellulose (LPNC) membranes that promotes the lateral flow of fluids enabling the application of various immunoreactants at different locations along a membrane strip. Enhanced one-step simple, rapid, disposable immunoassay devices that can be used in the home or in other remote testing sites. Does not require training or experienced personnel. Can easily be used in the home. Arista Biologicals Inc.

12. Today’s Market There are more than 250 commercial tests available for Human Diagnostics and Screening, Veterinary Diagnostics, Agriculture Testing and Environmental Screening. The Asian market is exhibiting the most rapid growth. There are over 200 manufacturers of Rapid Test Devices in the world. Increased competition creating pricing pressure. Arista Biologicals Inc.

13. Key Market Drivers Cost/Labor Reduction Reduced Turn-Around-Time (TAT) Disease Focused Testing Convenience and Simplicity Enhanced Clinical Utility Arista Biologicals Inc.

14. Rapid Test Device Market Segments OTC/Home Testing Professional POC/Remote Site Testing Arista Biologicals Inc.

15. OTC/Home Testing Market Pregnancy Drugs Of Abuse Fertility FOBT Arista Biologicals Inc.

16. Professional POC Testing Pregnancy Drugs Of Abuse Infectious Disease FOBT Arista Biologicals Inc.

17. Future Market Trends Increased demand for quantitative tests Growth Market Segments are Infectious Disease, Drugs-of-Abuse, Veterinary Diagnostics and Agricultural Testing Arista Biologicals Inc.

18. Key IVD Growth Assays (Not in order of projected value) Drugs-of-Abuse Cancer Screening Osteoporosis Hepatitis B & C HIV Diabetes Monitoring Cholesterol/Lipid Panel Cardiac Monitoring Saliva Based Tests Arista Biologicals Inc.

19. Patents in RTD Arista Biologicals Inc.

20. Patents; Our Opinion In no way do we encourage you to infringe upon the patent rights of other manufacturers of rapid test devices You have a responsibility to evaluate existing patent rights This is an area in which you must do your homework Arista Biologicals Inc.

21. Patents Patents; Why are they important? Obviously it is important not to infringe on other organizations’ patents The patent literature is one of the best sources of information for this technology Arista Biologicals Inc.

22. Patents Patents; Where can you find them? The Internet, the PTO site (Http://www.patents.ibm.com)Http://www.patents.ibm.com Certain data bases, Dialog, a very extensive cross-referenced data base that is the best source I know for foreign patents (Derwent file) Arista Biologicals Inc.

23. Patents Patents; Where can you find them? Care should be taken to search for patents outside the US European Patent Office Site (Http://www.epo.co.at/epo/)Http://www.epo.co.at/epo/ Most country patent offices now have a web site Arista Biologicals Inc.

24. Patents Patents; What should you do Carefully evaluate the existing patent literature Early in the process of concept development, work with your patent attorney Arista Biologicals Inc.

25. Patents Patents; Some solutions Seek a license Practice in a country not covered by the patent Invent around critical issues Arista Biologicals Inc.