1. GDRE EARLY PROGRAMMING OF MODERN DISEASES Stefania MACCARI, FR
CNRS: French National Scientific Council of Research
Stefania MACCARI, FR
Professor in Neurosciences
Head of Neuroplasticity Team
Structural and Fonctional Glycobiology Unit
UMR CNRS 8576
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 CNRS/USTL – IFR 147

2. Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 CNRS/USTL – IFR 147
Director:
Jean-Claude MICHALSKI 2 2

3. ROME BORDEAUX LILLE FRANCE-ITALY Network GDRE
EARLY PROGRAMMING OF MODERN DISEASES
GDRE
FRANCE-ITALY Network
ROME
BORDEAUX
LILLE
Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 CNRS/USTL – IFR 147 3

4. GDRE EARLY PROGRAMMING OF MODERN DISEASES
THE PRENATAL RESTRAINT STRESS MODEL AND AN IMPAIRED RESPONSE TO STRESS and ALTERED NEUROPLASTICITY 4

5. Restraint stress procedure : 100% french..

6. GDRE EARLY PROGRAMMING OF MODERN DISEASES
The network is headed by 2 co-coordinators:
Stefania Maccari
Anna Moles 6

7. European Research Network, GDRE
EARLY PROGRAMMING OF MODERN DISEASES, EPMD
THE ITALIAN NETWORK:
Anna Moles, CR
Francesca Romana D’Amato, CR
Martine Ammassari-Teule, DR
Sara Bellantuono, PhD Student
Luciana Garbugino, PhD Student
Roberto Coccurello, Post-Doc

8. GDRE EARLY PROGRAMMING OF MODERN DISEASES MONDAY, OCTOBER 19TH 2009
AT NAVY PIER, CHICAGO 8

9. EPMD Co-coordinators:
EARLY PROGRAMMING OF MODERN DISEASES
GDRE
Scientific Associate Director CNRS :
Bernard BIOULAC, FR (CNRS, Univ. Bordeaux 2)
EPMD Co-coordinators:
Stefania MACCARI, FR (CNRS, Univ. Lille1): Animal model PRS, Neuroproteomics, Depression
Anna MOLES, IT (CNR, Rome): Genomics and energy homeostasis
Members of EPMD:
Ferdinando NICOLETTI, IT (Univ. Rome): Metabotropic Glutamate Receptors and Depression
Arndt BENECKE, FR (CNRS Univ. Lille1, Lille2): Epigenomics
Annie DASZUTA, FR (CNRS, Univ. Marseille): Serotonin and adult neurogenesis
Sebastien BOURET, FR (Inserm Univ. Lille2), USA (Univ. Southern California): Neurodevelopment & obesity
Silvana GAETANI, IT (Univ. Roma): Endocannabinoids and feeding behaviour
Vincent PRÉVOT, FR (Inserm, Univ. Lille2): Reproduction
Valérie SIMONNEAUX, FR (CNRS, Univ. Strasbourg): Biological Rhythms
Paolo GIACOBINI, FR (Inserm, Univ. Lille2): GnRH neuronal migration
Thomas BORAUD, FR (CNRS, Univ. Bordeaux2): Neural substrate of motivated behaviours
Associated Partners:
Elisabeth MOCAER, FR (Servier): Agomelatine, antidepressant, intracellular mechanism
Fred TUREK, USA (Northwestern University): Sleep and Obesity 9

10. Neuronal Plasticity

11. GDRE EARLY PROGRAMMING OF MODERN DISEASES
Jerome Mairesse
Roma circadian studies & sleep lab. :
EARLY PROGRAMMING OF MODERN DISEASES, EPMD
European Research Network, GDRE 11

12. * *  depressive-like behavior: sleep alterations
EARLY PROGRAMMING OF MODERN DISEASES, EPMD
European Research Network, GDRE
Minutes / 24h *
Minutes / 24h *
Minutes / 24h
Reduced Slow Wave Sleep and increased REM
(Mairesse et al.)

13. Morley-Fletcher et al 2008 SFN
Hippocampus Proteome of PRS rats :
Down-regulation of proteins involved in neuroplasticity regulation
Sara Morley-Fletcher
Morley-Fletcher et al 2008 SFN

14. 1. Proteomics and post translational modifications?
Epigenomic approach
1. Proteomics and post translational modifications?

15. The “epigenetic role” of the mother
1. Energy homestasis
2. Emotional behaviour
3. Learning, memory and neuroplasticity
Anna Moles