1. © NextPharma Technologies 2006 NextPharma Technologies Experts in the production of Pellets

2. © NextPharma Technologies 2006 What We Can Do For You Formulation and Development of new products: Our Development Department is specialized in the development and formulation of new pellets and granule products. Its laboratory is specially equipped with the necessary technologies for this task. Production: The production of aqueous and organic granules, extrudates and pellets, coating, tabletting and capsule filling of granules and pellets.

3. © NextPharma Technologies 2006 What We Can Do For You Quality Control and Contract Analysis Modern and highly qualified laboratory for the analysis of all types of products (our specialist for the analysis of pellets), stability testing and development of analytical method.

4. © NextPharma Technologies 2006 Technologies Granulation: Aqueous and organic granulation (high shear mixer and fluid bed granulation) Extrusion / Spheronisation: For the production of homogeneous and organic extrudates and pellets Coating: Aqueous or organic coating of granules and pellets Layering Production of heterogeneous pellets using suspension-layering

5. © NextPharma Technologies 2006 Options for characteristics of produced pellets Controlled Release Can be achieved through: -Coating with special films (gastro resistant or pH independent diffusion film) -Difussion from Matrix-pellets Odour or Taste Masking By coating the pellets with specific films in order to mask the unsuitable odour or taste Colouring / Flavouring To enhance the patient compliance / acceptance by coating the pellets with accordingly special layers

6. © NextPharma Technologies 2006 Production of pellets with extrusion / spheronisation Blending & moistening High shear mixer:Ring die press (extruder): Extrusion extrudate Spheronisation Spheroniser: moist pellets Coating Kugelcoater: Fluid bed dryer: Drying

7. © NextPharma Technologies 2006 Extrusion / Spheronisation Equipment Blending & Moisting: Diosna P 400

8. © NextPharma Technologies 2006 Extrusion / Spheronisation Equipment Extrusion: Schlüter PP-127

9. © NextPharma Technologies 2006 Extrusion / Spheronisation Equipment Spheronisation: Schlüter RM-700

10. © NextPharma Technologies 2006 Extrusion / Spheronisation Equipment Fluid Bed Drying: Hüttlin HD 400

11. © NextPharma Technologies 2006 Production of pellets with suspension layering Non-pareil Layers with active substance Spraying nozzle Layers containing the active are sprayed onto non-pareils in a Kugelcoater (Bowl-coater)

12. © NextPharma Technologies 2006 Coating and Layering Equipment Fluid Bed Coater and Granulator: Hüttlin HKC 300-TJ

13. © NextPharma Technologies 2006 NextPharma Technologies