1. Case 1 45 y male Large ulcer on right leg----4-5 months ON examination An ulcer measuring 4x6 cm on medial Aspect of right leg just above the ankle joint. There is discharge of pus and blood from The ulcer.

2. Case 1 Pathology: Squamous cell carcinoma Local Radiology: no bone involvement MRI Leg: an ulcerated area of 4x4 cm Staging tests--?

3. Case 1 3 cycles of CF given. Remarkable response seen. Complete clearance of ulcerated wound followed by re-epithelization and scab formation.

4. Case 1

5. further treatment--? Surgery---? Radiotherapy--? Further cycles of chemotherapy----?

6. Case 2 50 y male Difficulty in passing stool----3-4 months Colonoscopy—in sigmoid colon,circumferential mass with friable mucosa causing narrowing of lumen,scope passed with difficulty.Rectum,ascending and descending colon normal. Biopsy taken.

7. Case 2 Pathology—Moderately differentiated adenocarcinoma CT Scan Abdomen:there is focal area of diffuse Circumferential thickening in the sigmoid colon Causing luminal narrowing and pericolonic Infiltration.It is measuring 8cm in length and 2.4cm in maximum wall thickness.

8. Case 2 Surgery: Tumor site----sigmoid colon Size of tumor---7.5x3.5cm Specimen dimension---22x6cm Procedure---abdominoperineal resection Specimen----sigmoid colon and rectum. Tumor configuration—exophytic polypoidal.

9. Case 2 margins: proximal margin---5 cm Distal margin---12 cm Mesentreric---9cm Perineural invasion—absent Lymphovascular invasion---absent All 15 nodes---negative

10. Case 2 Stage---pT3N0. Further Treatment-----?