1. Cellular Responses

2. 1111 2222 3333 4444 5555

3. What are the four components of repair? Angiogenesis Migration and proliferation of fibroblasts Deposition of ECM Remodeling

4. By 3-5 days of tissue repair, what specialized tissue appears? Granulation Tissue

5. What are the two major factors that induce angiogenesis? bFGF (basic fibroblast growth factor) VEGF (vascular endothelial growth factor)

6. What are the three phases of cutaneous wound healing? Inflammation Proliferation Maturation

7. This is the simplest type of cutaneous wound repair; healing of a clean, uninfected surgical incision that is then approximated by surgical sutures Healing by primary intention; primary union

8. Macrophage

9. This is the most important fibrogenic agent in cell proliferation TGF-B

10. What are the factors that influence wound healing? Nutrition Metabolic status Circulatory status Hormones Infection Mechanical factors Foreign bodies Size, location, and type of wound

11. Excessive formation of collagen that develops following thermal or traumatic injury can give rise to this Hypertrophic Scar

12. The signaling mechanism by which the cells respond to the signaling molecules that they themselves secrete Autocrine Signaling

13. This signaling mechanism occurs when one cell type produces the ligand and then acts on adjacent target cells that express the appropriate receptor Paracrine signaling

14. This signaling mechanism occurs when hormones synthesized by cells of endocrine organs act on target cells distant from their site of synthesis Endocrine signaling

15. These receptors transmit signals into the cell through trimeric GTP-binding proteins, contain seven transmembrane α-helices, and constitute the largest family of plasma membrane receptors G-Protein Coupled Receptors

16. This type of growth occurs by enlargement of the lobes of the liver that remain after the operation Compensatory growth or compensatory hyperplasia

17. This is the most abundant glycoprotein in the basement membrane and it contains binding domains for both ECM and cell surface receptors Laminin

18. This substance provides resilience and lubrication to connective tissue (notably for the cartilage in joints) and its concentration increases in inflammatory diseases Hyaluronan

19. These are represented by pale platelet and fibrin deposits alternating with darker red cell-rich layers. It signifies that a thrombus has formed in flowing blood Lines of Zahn

20. These are thrombi on heart valves resulting from blood-borne bacteria or fungi Vegetations

21. The consequences are impaired tissue perfusion and cellular hypoxia

22. This lesion in the maternal pulmonary microvasculature contains squamous cells, lanugo hair, fat from vernix caseosa, and mucin Amniotic Fluid Embolism