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SARC Developmental Therapeutics Committee Update Chand Khanna Open Science: Biology to Therapy” SARC Developmental Therapeutics Committee Update Chand Khanna Chawla/Rosenfeld Developmental Therapeutics Symposium “Open Science: Biology to Therapy” SARC Developmental Therapeutics
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SARC-DTC Members Chand Khanna, DVM, PhD (NCI) Chair Poul Sorenson, MD, PhD (UBC/BC Cancer Agency) Raphael Pollock, MD, PhD (MD Anderson) Kapil Dhingra, MD (KAPital Consulting) Jeffrey Trent, PhD (Tgen) David Kirsch, MD, PhD (Duke University) Peter Houghton, PhD (Ohio State University) *Shreyaskumar Patel, MD (MD Anderson) *Denise Reinke, MS, NP (SARC) *Ex Officio
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SARC Developmental Therapeutics Committee (DTC To establish an integrated and facile SARC effort closely aligned with the interests of pharmaceutical industry that can provide preclinical and translational data in sarcoma
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SARC – Development Therapeutics Committee Investigative Centers Providing SARC-DTC Services Sponsoring Pharmaceutical Partner Investigative Centers defined through SARC- DTC Investigative Centers engaged by SARC-DTC through Master Services Agreement SARC-DTC work scope managed through a research contract with Sponsors SARC-DTC Preclinical and Translational Study Report SARC-DTC Preclinical and Translational Infrastructure
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SARC – Development Therapeutics Committee Investigative Centers Providing SARC-DTC Services Investigative Centers defined through SARC- DTC Investigative Centers engaged by SARC-DTC through Master Services Agreement SARC-DTC Preclinical and Translational Infrastructure Current Investigative Center Portfolio >50 Sarcoma Cell Lines >30 Sarcoma Xenografts Sarcoma tissues Frozen tissues Sarcoma Tissue Arrays Genomics (SARComics Portal)
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SARC-DTC Preclinical and Translational Infrastructure Expansion of drug opportunities/assets for SARC clinical development through the development of preclinical and translational data in sarcoma Prioritization of SARC developmental path Opportunity to inform phase 1 and phase 2 transitions within SARC clinical development path Please help spread the word to interested parties of the opportunities to generate preclinical data in sarcoma through SARC
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SARC-Omics Portal To provide sarcoma investigators a consolidated portal for curation and viewing of “omics” data. To be developed through a collaboration of TGEN and SARC Screen shots expected at the SARC/CTOS 2013 in a matter of minutes…
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SARC Developmental Therapeutics Committee Update Chand Khanna SARC Developmental Therapeutics Committee Update Chand Khanna Chawla/Rosenfeld Developmental Therapeutics Symposium Chawla/Rosenfeld Developmental Therapeutics Symposium
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Chawla Rosenfeld Developmental Therapeutics Symposium Open Science: Biology to Therapy A Case for Open-Source Drug Discovery – J. Bradner Anti-angiogenic activity of JQ1 in Sarcomas – H. Bid The Sarcoma Data Portal: Making High Content Sarcoma Datasets Available For All Users – J. Keats Discussion (20 min)
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