1. Cell Cycles and Mitosis

2. The Cell Cycle INTERPHASE Cell Growth and Replication of DNA
A. 1st Growth Phase
B. S (synthesis) Phase-DNA Replicated
C. 2nd Growth Phase
MITOSIS
Division of DNA
A. Prophase
B. Metaphase
C. Anaphase
D. Telophase
CYTOKINESIS
Division of Cytoplasm

3. So are my cells dividing….right now?
At this exact moment, what phase of the cell cycle would most of your body cells be in?
Interphase
Some cells constantly divide to form new cells
EXAMPLE: skin cells, stomach cells, stem cells, and cells in a developing embryo).
Other cells don’t divide at all after the organism matures
EXAMPLE: nerve and muscle cells.

4. Summary of Events in the Process of Mitosis and Cell Division
Begin with: DNA Replication: Condense DNA: Split chromatids: End with:
46 pieces of replicated chromatin
46 (or 23 pairs) of double arm chromosomes
92 single arm chromosomes
46 pieces of chromatin per cell
46 pieces of chromatin in humans

5. PHASES OF THE CELL CYCLE

6. Interphase Period of cell growth and DNA replication.
What types of processes might be taking place in a cell during interphase?
Production of organelles, photosynthesis, Most of the cells’ metabolism occurs here.
Is the cell shown below an animal or plant cell?
Animal
How can you tell?
Does not have a cell wall

7. Interphase
A. G1 phase—Period of Cell Growth Synthesis of proteins and cell organelles occurs in preparation for division. B. S phase—DNA Replication! C. G2 phase—Continued growth and preparations for cell division. Centrioles in animal cell divide.

8. MITOSIS: Prophase
1. Replicated DNA condenses into double-arm chromosomes.
2. Nuclear membrane breaks down and nucleoli disappear.
3. Spindle fibers form at ends of the cell.
4. Centrioles in animal cells move to opposite ends of the cell.

9. MITOSIS: Metaphase
1. Double-arm chromosomes line up on the middle or “equator” of the cell.
2. Spindle fibers attach to chromatids at the centromere.
Equator
Pole
Pole

10. MITOSIS: Anaphase
1. Spindle fibers contract, causing centromeres to split and identical chromatids to separate.
2. Single-arm chromosomes move to opposite ends or “poles” of the cell.

11. MITOSIS: Telophase 1. Chromosomes unravel into chromatin.
2. Nuclear membrane reforms and nucleolus reforms.
3. Spindle fibers break down.
4. Furrow in animal cell forms (or cell plate in plant cells) as the cytoplasm begins to divide.

12. CYTOKINESIS
A. Cytoplasm divides B. Furrow or cell plate is completed. C. Two, identical “daughter” cells are formed.

13. Differences Between Animal and Plant Mitosis and Cytokinesis
Centrioles
organelles that aid in cell division that are only found in animal cells
Cytokinesis
1) Furrow-in animal cells indentations in the cell membranes
2) Cell plate in plant cells- formation of the cell membrane from vesicles budding off the golgi apparatus-a new cell wall then grows from the formation of cellulose.

14. Frequency and length of time for the cell cycle depends on…
Kingdom of cell-
Plants hours Animals _18-24 hours
Type of cell-
Skin, stomach, embryonic cells frequently divide
Mature nerve, blood and muscle cells do not divide.
Size of cell (SA/V ratio)
Nutrients available
Density of cells.
Age of Cells-
the ends of chromosomes (called telomeres) shorten each time a cell divides. After a certain number of divisions (about 50) the cell stops dividing. 

15. Cancer
Uncontrolled mitotic division in cells. This can be caused by “bad” genes or environmental mutagens like UV radiation, cigaraette smoke, etc.)