1. ESTIMATION

2. STATISTICAL INFERENCE It is the procedure where inference about a population is made on the basis of the results obtained from a sample drawn from that population It is the procedure where inference about a population is made on the basis of the results obtained from a sample drawn from that population

3. STATISTICAL INFERENCE This can be achieved by : This can be achieved by : Hypothesis testing Estimation: Point estimation Interval estimation Interval estimation

4. Estimation If the mean and the variance of a normal distribution are known, then the probabilities of various events can be determined. If the mean and the variance of a normal distribution are known, then the probabilities of various events can be determined. But almost always these values are not known, and we have to estimate these numerical values from information of a simple random sample But almost always these values are not known, and we have to estimate these numerical values from information of a simple random sample

5. Estimation The process of estimation involves calculating from the data of a sample, some “statistic” which is an approximation of the corresponding “parameter” of the population from which the sample was drawn The process of estimation involves calculating from the data of a sample, some “statistic” which is an approximation of the corresponding “parameter” of the population from which the sample was drawn

6. POINT ESTIMATION It is a single numerical value btained from a random sample used to estimate the corresponding population parameter It is a single numerical value btained from a random sample used to estimate the corresponding population parameter _ Sample mean (X) is the best point estimate for population mean( µ ) Sample mean (X) is the best point estimate for population mean( µ )

7. POINT ESTIMATION Sample standard deviation (s) is the best point estimate for population standard deviation ( σ ) Sample standard deviation (s) is the best point estimate for population standard deviation ( σ ) ~ Sample proportion ( P) is the best point estimator for population proportion (P) Sample proportion ( P) is the best point estimator for population proportion (P)

8. But, there is always a sort of sampling error that can be measured by the Standard Error of the mean which relates to the precision of the estimated mean But, there is always a sort of sampling error that can be measured by the Standard Error of the mean which relates to the precision of the estimated mean

9. Because of sampling variation we can not say that the exact parameter value is some specific number, but we can determine a range of values within which we are confident the unknown parameter lies Because of sampling variation we can not say that the exact parameter value is some specific number, but we can determine a range of values within which we are confident the unknown parameter lies

10. INTERVAL ESTIMATION It consists of two numerical values defining an interval within which lies the unknown parameter we want to estimate with a specified degree of confidence It consists of two numerical values defining an interval within which lies the unknown parameter we want to estimate with a specified degree of confidence

11. INTERVAL ESTIMATION The values depend on the confidence level which is equal to 1-α (α is the probability of error) The values depend on the confidence level which is equal to 1-α (α is the probability of error) The interval estimate may be expressed as: The interval estimate may be expressed as: Estimator ± Reliability coefficient X standard error Estimator ± Reliability coefficient X standard error

12. INTERVAL ESTIMATION Standard error EstimatorParameter σ /√ n Sample mean_ ( X) ( X) Population mean ( µ )

13. INTERVAL ESTIMATION Standard error EstimatorParameter √ (σ 2 1 /n 1 )+ (σ 2 2 /n 2 ) Difference between two sample means _ _ _ _ ( X 1 -X 2 ) ( X 1 -X 2 ) Difference between two population means ( µ 1 - µ 2 )

14. INTERVAL ESTIMATION Standard error EstimatorParameter ~ ~ ~ ~ √ p(1-p)/n (since P is unknown, and we want to estimate it) Sample proportion ~(P) Population proportion ( P)

15. INTERVAL ESTIMATION Standard error EstimatorParameter ~ ~ ~ √ p 1 (1-p 1 )/n 1 + p 2 (1- ~ p 2 )/n 2 Difference between two Sample proportion ~ ~ P 1 -P 2 Difference between two Population proportions ( P 1 -P 2 )

16. Reliability Coefficient The reliability coefficient is the value of The reliability coefficient is the value of Z 1- α /2 corresponding to the confidence level Z 1- α /2 corresponding to the confidence level

17. Reliability Coefficient Z-value α -value Confidence level 1.6450.190% 1.960.0595% 2.580.0199%

18. Confidence Interval The Confidence Interval is central and symmetric around the sample mean, so that there is (α/2 %) chance that the parameter is more than the upper limit, and (α/2 % ) chance that it is less than the lower limit The Confidence Interval is central and symmetric around the sample mean, so that there is (α/2 %) chance that the parameter is more than the upper limit, and (α/2 % ) chance that it is less than the lower limit

19. CI FOR POPULATION MEAN The sample mean is an unbiased estimate for population mean The sample mean is an unbiased estimate for population mean If the population variance is known, CI around µ : If the population variance is known, CI around µ : _ _ _ _ { X- Z 1- α /2 x σ /√ n < µ < X + Z 1- α /2 x σ /√ n } { X- Z 1- α /2 x σ /√ n < µ < X + Z 1- α /2 x σ /√ n }

20. EXERCISE The mean s.indirect bilirubin level of 16 four days old infants was found to be 5.98 mg/dl. The population SD (σ)=3.5 mg/dl. Assuming normality, find 90,95, 99% CI for µ : The mean s.indirect bilirubin level of 16 four days old infants was found to be 5.98 mg/dl. The population SD (σ)=3.5 mg/dl. Assuming normality, find 90,95, 99% CI for µ : _ _ _ _ {X- Z 1- α /2 x σ /√ n < µ < X + Z 1- α /2 x σ /√ n} {X- Z 1- α /2 x σ /√ n < µ < X + Z 1- α /2 x σ /√ n}

21. EXERCISE _ _ _ _ CI{X- Z 1- α /2 x σ /√ n < µ < X + Z 1- α /2 x σ /√ n}=1- α CI{X- Z 1- α /2 x σ /√ n < µ < X + Z 1- α /2 x σ /√ n}=1- α 90%CI= {5.98- 1.645 * 3.5 /√ 16 < µ < 5.98 + 1.645 * 3.5 /√ 16}=1- 0.1 90%CI= {5.98- 1.44 < µ < 5.98 + 1.44}=1- 0.1 90%CI= {4.54 < µ < 7.42}

22. _ _ _ _ CI{X- Z 1- α /2 x σ /√ n < µ < X + Z 1- α /2 x σ /√ n}=1- α CI{X- Z 1- α /2 x σ /√ n < µ < X + Z 1- α /2 x σ /√ n}=1- α 95%CI {5.98- 1.96 * 3.5 /√ 16 < µ < 5.98 + 1.96 * 3.5 /√ 16} 95%CI {5.98- 1.715 < µ < 5.98 + 1.715} 95%CI {4.265 < µ < 7.695}

23. _ _ _ _ CI{X- Z 1- α /2 x σ /√ n < µ < X + Z 1- α /2 x σ /√ n}=1- α CI{X- Z 1- α /2 x σ /√ n < µ < X + Z 1- α /2 x σ /√ n}=1- α 99%CI{5.98- 2.58 * 3.5 /√ 16 < µ < 5.98 + 2.58 * 3.5 /√ 16} 99%CI{5.98- 2.258 < µ < 5.98 + 2.258} 99%CI={ 3.72 < µ < 8.24}

24. CI for difference between two population means A sample of 10 twelve years old boys and a sample of 10 twelve years old girls yielded mean height of 59.8 inches (boys), and 58.5 inches (girls). Assuming normality and σ 1 =2 inches, and σ 2 = 3 inches. Find 90% CI for the difference in means of height between girls and boys at this age. A sample of 10 twelve years old boys and a sample of 10 twelve years old girls yielded mean height of 59.8 inches (boys), and 58.5 inches (girls). Assuming normality and σ 1 =2 inches, and σ 2 = 3 inches. Find 90% CI for the difference in means of height between girls and boys at this age.

25. CI for difference between two population means _ _ _ _ _ _ _ _ CI{ ( X 1 -X 2 ) -Z √ (σ 2 1 /n 1 )+ (σ 2 2 /n 2 )< ( µ 1 - µ 2 )< ( X 1 -X 2 )+ Z √ (σ 2 1 /n 1 )+ (σ 2 2 /n 2 ) } 90%CI{ ( 59.8-58.5) -1.645 √ (2) 2 /10)+ (3) 2 /10)< ( µ 1 - µ 2 )< ( 59.8-58.5)+1.645 √ (2) 2 /10)+ (3) 2 /10) } 90%CI{ 1.3 -1.88< ( µ 1 - µ 2 )< 1.3+ 1.88 } 90%CI{ -0.58< ( µ 1 - µ 2 )< 3.18 }

26. CI for population proportion In a survey 300 adults were interviewed, 123 said they had yearly medical checkup. Find the 95% for the true proportion of adults having yearly medical checkup. In a survey 300 adults were interviewed, 123 said they had yearly medical checkup. Find the 95% for the true proportion of adults having yearly medical checkup. ~ 123 ~ 123 P=-------=0.41 P=-------=0.41 300 300

27. CI for population proportion ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ CI{P-Z √ p(1-p)/n<P<P+Z √ p(1-p)/n}=1-α 95%CI{0.41-1.96 √ 0.41(1-0.41)/300<P<0.41+1.96 √ 0.41(1-0.41)/300} √ 0.41(1-0.41)/300} 95%CI{0.41- 0.06<P<0.41+0.06} 95%CI{0.35<P<0.47} 95%CI= 35-47%

28. CI for difference between two population proportions 200 patients suffering from a certain disease were randomly divided into two equal groups. The first group received NEW treatment, 90 recovered in three days. Out of the other 100 who received the STANDARD treatment 78 recovered within three days. Find the 95% CI for the difference between the proportion of recovery among the populations receiving the two treatments 200 patients suffering from a certain disease were randomly divided into two equal groups. The first group received NEW treatment, 90 recovered in three days. Out of the other 100 who received the STANDARD treatment 78 recovered within three days. Find the 95% CI for the difference between the proportion of recovery among the populations receiving the two treatments

29. Answer ~ ~ 90 78 ~ ~ 90 78 P 1 -P 2 =------- - ---------=0.12 P 1 -P 2 =------- - ---------=0.12 100 100 100 100

30. Answer ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ CI ( P 1 -P 2 )-Z √ p 1 (1-p 1 )/n 1 + p 2 (1-p 2 )/n 2 < P 1 -P 2 < ( P 1 -P 2 )+Z ~ ~ ~ ~ ~ ~ ~ ~ √ p 1 (1-p 1 )/n 1 + p 2 (1-p 2 )/n 2 95% CI=0.12± 1.96 √ 0.9(1.0.9)/100 + 0.78(1-0.78)/100 95%CI=0.12 ± 0.1 95%CI =0.02-0.22 ( 2-22%)

31. The width of the interval estimation is increased by: The width of the interval estimation is increased by: Increasing confidence level (i.e.: decreasing alpha value) Increasing confidence level (i.e.: decreasing alpha value) Decreasing sample size Decreasing sample size

32. Confidence level can shade the light on the following information: Confidence level can shade the light on the following information: 1.The range within which the true value of the estimated parameter lies

33. 2.The statistical significance of a difference ( in population means or proportions). If the ZERO value is included in the interval of such differences( i.e.: the range lies between a negative value and a positive value), then we can state that there is no statistically significant difference between the two population values (parameters), although the sample values (statistics) showed a difference If the ZERO value is included in the interval of such differences( i.e.: the range lies between a negative value and a positive value), then we can state that there is no statistically significant difference between the two population values (parameters), although the sample values (statistics) showed a difference

34. 3.The sample size. A narrow interval indicates a “ large ” sample size, A narrow interval indicates a “ large ” sample size, while a wide interval indicates a “ small ” sample while a wide interval indicates a “ small ” sample size (with fixed confidence level) size (with fixed confidence level)

35. EXERCISES In a study to assess the side effects of two drugs, 50 animals were given Drug A (11 showed undesirable side effects), and 50 were given Drug B (8 showed similar side effects). In a study to assess the side effects of two drugs, 50 animals were given Drug A (11 showed undesirable side effects), and 50 were given Drug B (8 showed similar side effects). Find the 95% CI for P A -P B Find the 95% CI for P A -P B

36. EXERCISES In a random sample of 100 workers, the mean blood lead level was 90 ppm. If the distribution of blood lead level in workers population is normal with a standard deviation of 10 ppm. In a random sample of 100 workers, the mean blood lead level was 90 ppm. If the distribution of blood lead level in workers population is normal with a standard deviation of 10 ppm. Find the 90,95,and 99% CI for the population mean. Find the 90,95,and 99% CI for the population mean.

37. EXERCISE In assessing the relationship between a certain drug and a certain anomaly in chick embryos, 50 fertilized eggs were injected with the drug on the 4 th day of incubation. On the 20 th day the embryos were examined and in 12 the presence of the abnormality was observed. Find the 90,95, and 99% CI for the population proportion. In assessing the relationship between a certain drug and a certain anomaly in chick embryos, 50 fertilized eggs were injected with the drug on the 4 th day of incubation. On the 20 th day the embryos were examined and in 12 the presence of the abnormality was observed. Find the 90,95, and 99% CI for the population proportion.

38. EXERCISE If the Hb level of males aged >10 years is normally distributed with a variance of 1.462 (gm/dl) 2, and that of males below 10 years is also normally distributed with a variance of 0.867 (gm/dl) 2. If a random sample of 10 older and 20 younger males are selected, and showed sample means of 14.47 gm/dl, and 12.64 gm/dl, respectively. Find the 90, 95, and 99% CI for the difference in population means. If the Hb level of males aged >10 years is normally distributed with a variance of 1.462 (gm/dl) 2, and that of males below 10 years is also normally distributed with a variance of 0.867 (gm/dl) 2. If a random sample of 10 older and 20 younger males are selected, and showed sample means of 14.47 gm/dl, and 12.64 gm/dl, respectively. Find the 90, 95, and 99% CI for the difference in population means.