1. Todays Clinical Trials. Tomorrow’s Cures. Robert L. Comis, MD 1 National Coalition for Cancer Research “Cancer 101” Congressional Briefing 09/10/14

2. Publicly funded $243 million/yr. Pharmaceutical industry $ billions/yr. Cancer Clinical Trials in the U.S. 2

3. Industry Support for Cancer Clinical Trials Goals: – Obtain FDA approval to market a new drug or extend the label of an existing agent – Create shareholder value Approach: – Design studies to demonstrate efficacy of a new agent for a specific indication in a specific patient population 3

4. Publicly-Funded Cancer Clinical Trials Goal: – Maximize benefit to patients and society Approaches: – Compare effective and promising regimens with each other – Optimize multi-modality approaches – Develop therapies for rare cancers – Optimize cancer prevention, screening, survivorship, and quality of life strategies 4

5. National Clinical Trials Network 5