1. Recurrence of Malignancy after Transplantation ANZDATA - Australian and New Zealand Dialysis and Transplant Registry NSW Cancer Council

2. Recurrence of Malignancy ISSUES Donor Recipient

3. Timing of Cancer Diagnosis Tx DEATH CANCER DIALYSIS PRE Dx POST Dx

4. Number of Patients with Cancer ANZDATA Database 1999 CancerPre DxPost Dx Skin454777 Kidney406 73 Myeloma192 20 Bladder162 93 Breast 141 66 Colon 129 56 Prostate126 42 Melanoma 95 48 Rectal 55 20 Cervix 55 15 ALL Non skin Cancer1718789

5. Recurrence of cancer after RENAL TRANSPLANTATION ANZDATA pre transplant Cancers 1963- 1999 # Tx Recurrence –Colon230 –Breast200 –Female genital202 –Prostate 51 –Bladder241 –Kidney372 –Ureter 10 –Melanoma192 –Lymphoma100 –Myeloma 40 –Other non-skin473 –TOTAL21011 –No prior Cancer11684

6. Recurrence of cancer after RENAL TRANSPLANTATION Dead Tx ANZDATA Months Follow Up

7. ANZDATA Patient survival after Renal Transplantation CD1 1985 - 1999

8. Diagnosis of Cancer pre-Transplant Patients at risk = 27,495 Pt Years at risk = 1,361,200

9. Survival after Diagnosis Cancer diagnosed pre-dialysis Median Survival in Years ANZDATA 108642 0

10. Survival after Diagnosis Cancer diagnosed post-dialysis Median Survival in Years ANZDATA 108642 0

11. Comparison of 5 year survival of general and dialysis populations

12. Breast Cancer ANZDATA 1999 vs NSW Cancer Databases POPULATIONS 43% 33%

13. Myeloma ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

14. Colon Cancer ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

15. Bladder Cancer ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

16. Kidney Cancer ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

17. Melanoma ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

18. Lymphoma ANZDATA 1999 vs NSW Cancer Databases POPULATIONS

19. Lymphoma Melanoma Kidney Bladder Colon Breast

20. Cancer in Uraemic populations ANZDATA - are the data real? review of all cases review causes of death review metastasis diagnoses review therapy Acknowledgements: Brian Livingston, Ross Sheil