1. Chapter 4 Histology: Study of Tissues

2. TISSUE TYPES Epithelial Connective Muscle Nervous

3. Embryonic Development Blastocyst- ball of cells Germ layers: –Endoderm- outer layer –Mesoderm- middle layer –Ectoderm- inner layer Gastrulation- process of blastocyst to germ layers Histogenesis- process of germ layers developing into different kinds of tissues.

4. Epithelial Tissue Types & locations – membranous: cover/lining; found in serous cavities, bld & lymph vessels, respiratory, digestive & genitourinary tracts. –Glandular: grouped in solid cords or specialized follicles that form secretory units of endocrine & exocrine glands.

5. Epithelial Tissue Functions –Protection –Sensory functions –Secretion –Absorption –Excretion

6. Epithelial Tissue Generalizations –Limited matrix material –Connects to connective tissue –Avascular –Cells tightly packed –Frequently replace themselves

7. Epithelial Tissue Classifications –Membranous epithelium Classification based on cells shape –Squamous cells –Cubiodal cells –Columnar cells –Pseudostratified columnar cells

8. Epithelial Tissue Classifications –Classification based on layers of cells Simple epithelium Stratified epithelium Transitional epithelium

9. Epithelial Tissue Glandular epithelium –Unicellular glands- single-celled glands; Goblet Cells –Multicellular glands- clusters, solid cords, specialized follicles –Exocrine glands- secrete into ducts –Endocrine glands- ductless glands

10. Connective Tissue Categories Embryonic or mesenchyme Adult –Loose –Dense –Connective tissue with special properties –Cartilage –Bone –Blood

11. Extracellular Matrix Components –Protein fibers Collagen which is most common protein in body Reticular fill spaces between tissues and organs Elastic returns to its original shape after distension or compression –Ground substance Shapeless background –Fluid

12. Loose Connective Tissue Also known as areolar tissue Loose packing material of most organs and tissues Attaches skin to underlying tissues Contains collagen, reticular, elastic fibers and variety of cells

13. Dense Connective Tissue Dense regular –Has abundant collagen fibers Tendons: Connect muscles to bones Ligaments: Connect bones to bones Dense regular elastic Ligaments in vocal folds Dense irregular Scars Dense irregular collagenous Forms most of skin dermis Dense irregular elastic In walls of elastic arteries

14. Connective Tissue with Special Properties Adipose tissue- Fat storage –Consists of adipocytes –Types Yellow (white) –most abundant, white at birth and yellows with age Brown – found only in specific areas of body as axillae, neck and near kidneys Reticular tissue –Forms framework of lymphatic tissue –Characterized by network of fibers and cells

15. Cartilage Composed of chondrocytes located in spaces called lacunae Next to bone firmest structure in body Types of cartilage –Hyaline –Fibrocartilage –Elastic

16. Hyaline Cartilage Found in areas for strong support and some flexibility –Rib cage and cartilage in trachea and bronchi Forms most of skeleton before replaced by bone in embryo Involved in growth that increases bone length

17. Fibrocartilage Slightly compressible and very tough Found in areas of body where a great deal of pressure is applied to joints –Knee, jaw, between vertebrae

18. Elastic Cartilage Rigid but elastic properties –External ears, epiglottis

19. Osseous Tissue Commonly called bone tissue Function is to support & protect Made of osteocytes Compact Bone Cancellous or Spongy Bone

20. Blood Matrix between the cells is liquid Hemopoietic tissue –Forms blood cells –Found in bone marrow Yellow Red

21. Muscle Tissue Characteristics –Contracts or shortens with force –Moves entire body and pumps blood Types –Skeletal- moves bones Striated and voluntary –Cardiac- pumps heart Striated and involuntary –Smooth- covers organs; moves fluids Nonstriated and involuntary

22. Nervous Tissue Found in brain, spinal cord and nerves Ability to produce action potentials Cells –Nerve cells or neurons Consist of dendrites, cell body, axons Consist of multipolar, bipolar, unipolar –Neuroglia or support cells

23. Membranes Mucous –Line cavities that open to the outside of body –Secrete mucus Serous –Line cavities not open to exterior Pericardial, pleural, peritoneal Synovial –Line freely movable joints –Produce fluid rich in hyaluronic acid

24. Inflammation Response when tissues damaged or with an immune response Manifestations –Redness, heat, swelling, pain, disturbance of function Mediators –Include histamine, kinins, prostaglandins, leukotrienes –Stimulate pain receptor and increase blood vessel permeability