1. Regenstrief Institute’s New Medical Gopher: A Next-Generation Open-Source Physician Order Entry System Jon D. Duke, MD, MS Burke Mamlin, MD Doug Martin MD MedInfo 2013

4. Gopher Gopher grew from a single clinic to over 1000 workstations, inpatient, outpatient, ED 25+ years of iterations has resulted in robust functionality and efficiency Served as the research platform for many of the seminal studies in healthcare computing

5. 19842010

6. In 2009 Regenstrief Institute began rebuilding its core clinical information system platform In 2010, we began work on a new web-based version of the venerable Gopher This system was designed using the knowledge gained from the past 25 years of Gopher as well as from the evolving literature on CPOE system design Developing the new Gopher

7. Started with a Blank Slate

8. Improve User Satisfaction Support Patient Safety Improve Quality of Care Promote Provider Efficiency Guiding Principles

9. Set Gravity in the Right Direction Leverage Metaphors Constrain Then Innovate Design Strategies

10. Leverage Metaphors

11. Leveraging Metaphors

15. E-Commerce

16. Workflow Wizards

17. Smart Autocompletion

18. Constrain Then Innovate

19. 140 characters hashtags retweets url shorteners brevity Instagram Vine Yammer Waze

20. Screen Real Estate At outset of development process, set aside an untouchable area of screen real estate That area– the InfoPanel– was not utilized for >1 year into development but has become a critical asset

22. Set Gravity in the Right Direction

23. Right Thing Wrong Thing User

24. Formulary Recognition

25. Allergy Entry

26. Fitt’s Law

28. What’s inside the new Gopher? Data capture –Order entry –Note Writing –Observations –Patient Letters –Document uploader –Electronic signature –Problem list management –Allergy Management –Order Sets –Natural Language Processing Results display –Recent results –Flowsheet –Clinical abstract –Clinical documents –Encounter display –Order summary –Appointment history –Patient dashboard –Medication summary –Chart search Clinical Decision support –Alert display –InfoPanel –Rule Authoring –Relevance Adjustment Module –FDB Integration Setting-specific functionality –Outpatient –Inpatient –Emergency Department – Touch interface Administrative Tools –User management –Remote troubleshooting –Property management –Concept mapping –Disaster aid support System integration –McKesson portal –Relay Health portal –Docs4Docs integration Research –Randomization –Medication adherence –Medication reconciliation –Med profile visualization –ResNet Recruitment –SMART plug-ins Certifications –Meaningful Use Inpt / Outpt –NCPDP e-Prescribing Reporting –Population search

29. Major Functions Order entry Documentation / note writing Medication / problem / allergy management Results viewing Research Clinical decision support

30. Advancements in New Gopher Context-Driven Dynamic Alerts Adaptive Learning Real-time Natural Language Processing Multimedia Alerts Advanced Rule Authoring

31. Advancement #1: Dynamic Alerts Gopher has embedded mechanics to dynamically change alert display based on context – Patient – Physician – Institutional

32. Alerting Zones

33. Relevance Adjustment Module Every alert has a baseline relevance level which determines its display location For example, for DDI alerts, about 40% are interruptive and 60% non-interruptive The RAM can adjust this default level

34. DDI Alert Service DDI Alert Service TRIAMTERENE Interacts with LISINOPRIL Risk of Hyperkalemia Severity: Moderate Relevance: 5 (Average) TRIAMTERENE Interacts with LISINOPRIL Risk of Hyperkalemia K 5.3*, Cr 1.3, GFR 55 Relevance: 7 (High) Lisinopril Order Related Concepts Hyperkalemia Has Relevant Labs: K, Cr, GFR Data Repository Data Repository K, Cr, GFR Relevance Adjustment Module Original AlertFinal Alert Patient has lab values: K 5.3*, Cr 1.3, GFR 55

36. DDI Alert Service DDI Alert Service TRIAMTERENE Interacts with LISINOPRIL Risk of Hyperkalemia Severity: Moderate Relevance: 5 (Average) TRIAMTERENE Interacts with LISINOPRIL Risk of Hyperkalemia K 3.3, Cr 0.8, GFR 114 Relevance: 3 (Low) Lisinopril Order Related Concepts Hyperkalemia Has Relevant Labs: K, Cr, GFR Data Repository Data Repository K, Cr, GFR Relevance Adjustment Module Original AlertFinal Alert Patient has lab values: K 3.3, Cr 0.8, GFR 55

38. Relevance Adjustment Module RAM can also make changes based on provider characteristics For example, can make particular alerts non- interruptive for certain specialties Conversely, for medical students all alerts can be made interruptive

39. TM Nintendo Advancement #2: Gopher is a Learning System

40. Gopher can track user actions and activity such as – Number of logins – Frequently selected orders – Responses to previous alerts Can customize system behavior based on individual user history

41. Alerts That Learn Picture of learning message, then another of the small alert Diazepam Diazepam 5 MG

42. Alerts That Learn Diazepam Diazepam 5 MG

43. Advancement #3: Natural Language Processing Gopher can analyze notes in real-time Can determine section (e.g., FHx, PMH) to give context to the concepts retrieved Multiple services may be run simultaneously (e.g.,CDS, quality metrics, study recruitment) Results may be displayed as alert or used for background data capture Section header detection thanks to SecTag from Vanderbilt University: http://knowledgemap.mc.vanderbilt.edu/research/content/sectag-tagging-clinical-note-section-headers

44. Order Detection

45. Study Reminders

46. Natural Language Processing Can be used as a CDS trigger Can be used to enhance structured documentation for ‘meaningful use’ Can be used for clinical research Integrated with our Advanced Rule Authoring environments

47. Advancement #4: Multimedia Alerts

49. Adherence Information

50. Research Study Eligibility

51. Advancement #5: Advanced Rule Authoring The Rule Authoring and Validation Environment (RAVE) is a rule authoring tool within Gopher The RAVE is designed to empower stakeholders to create complex, rule-based actions using a simple graphical interface

52. Rule Authoring Rules are necessary to drive decision support logic as well as other system actions Rule authoring is generally a complex task requiring code-like syntax

54. Good artists copy. Great artists steal. - Pablo Picasso

55. ifttt.com

56. Great Artists Steal

60. RAVE = IFTTT for EMRs Built a variety of channels for EMR activities Channels may server as – Triggers (If) – Actions (Then) – Both Additionally, we added a ‘For’ component to specify when the rule should be run

61. Rule Authoring and Validation Environment Picture HERE

62. Rule Authoring and Validation Environment Picture HERE

63. Rule Authoring and Validation Environment Picture HERE

64. RAVE Channels If Channels Orders Diagnoses Allergies Note NLP Chart Actions Observations ADT HL7 Then Channels Alerts Email / SMS Logging Observations For Channels Patient User

65. FOR: Patient Channel Picture HERE

66. IF: Diagnosis Channel Picture HERE

67. THEN: Alert Channel Picture HERE

68. RAVE Output Picture HERE

69. RAVE Output Picture HERE

70. RAVE DROOLS Syntax Picture HERE

71. Rule Authoring and Validation Environment

72. RAVE = Customizability Can mix and match channels to create a remarkable array of functionality without need for programmer intervention Can write rules just for yourself or (with permission) your clinic, specialty, or all users Rule syntax is generated automatically in a standard rules syntax (Drools)

73. GopherGopher DemoDemo

74. Gopher and Open Source Regenstrief is philosophically and contractually committed to release of the new Gopher platform as open source software We are looking for partners to take part in both software development and community building around this effort Please let us know if this is something you would be willing to commit time and energy to pursuing

75. Acknowledgements Chris Beesley Chris Bonham Mike Brehm Jason Cadwallader Joshua Castagno Vidhya Chari Parishkar Chauhan Ling Cheng Sireesha Chilukuri Cyril Colvard Jonathan Cummins Alex Franken Cindi Hart Charity Hilton Joshua Jones Warren Killian Jeremy Leventhal Allen Logan Ernesto Maldonado Burke Mamlin Andrew Martin Doug Martin Jim Meeks-Johnson Pat Milligan Justin Morea Chris Power Linas Simonaitis Kenneth Spry Jeff Stroup Blaine Takesue David Taylor Jeff Warvel Jennifer Weatherspoon Chen Wen

76. Questions? jduke@regenstrief.org