1. STT520-420: BIOSTATISTICS ANALYSIS Dr. Cuixian Chen Chapter 1: Introduction to Biostatistics Analysis STT520-420 1

2. EXAMPLES OF BIOSTATISTICS 1. Is breastfeeding by HIV positive mothers associated with infant mortality? 2. Is hormone replacement therapy associated with heart disease or stroke? 3. Do patients taking Vioxx have an increasing risk of stroke? 4. How are the MRI brain scans for schizophrenic patients different from people without the disease? STT520-420 2

3. EXAMPLES OF BIOSTATISTICS Where do Biostatisticians work: 1. Academic fields 2. Government (e.g.: FDA) 3. Non-profit organizations 4. Pharmaceutical companies or Contracted Research Organizations (Local CRO – PPD, Chiltern, Quintiles)Quintiles ) STT520-420 3

4. THE ROLE OF BIOSTATISTICS Biology: Is the productivity and yield of maize significantly effected by the environment: drought, UV or both? Statistician: Designing studies for and analyzing data from agricultural experiments to increase productivity and yield. STT520-420 4

5. AVERAGE SALARY OF JOBS WITH RELATED TITLES FROM HTTP://WWW.INDEED.COM/SALARY/STATISTICIAN.HTMLHTTP://WWW.INDEED.COM/SALARY/STATISTICIAN.HTML STT520-420 5

6. EXAMPLES OF BIOSTATISTICS Typical Activity of a Biostatistician: 1. Sample size requirement 2. Analysis plan at design stage 3. Randomization 4. Sampling design 5. Statistical Analysis: Descriptive and inferential statistics analysis STT520-420 6

7. Biostatistics Courses requirements  Biostatistics Analysis/Survival Analysis (STT520/420);  Design of Experiments and Analysis of Variance (STT511/411);  Applied Regression and Correlation (STT512/412);  Nonparametric Statistics (STT530/430);  Categorical Data Analysis (STT525/425);  Linear/Multivariate Models and Regression Analysis (STT540/440);  Statistical Inference (STT566/466);  Additional: Probability, Longitudinal Analysis,  Generalized Linear Model; STT520-420 7

8. Typical Job duty of Biostatistician Duty of Biostatistician:  Write/review Statistical Analysis Plan (SAP).  Write/review statistical section of protocol including sample size calculation, develop randomization schedule, mock up table shells/listing shells, provide specifications to programmers.  Quality control the table from SAS programmer, and review listings.  Validate deliverables. STT520-420 8

9. Typical Job duty of SAS programmer Duty for SAS programmer:  Data validation: Data cleaning, Error checking.  Build analysis database, based on the specifications from Biostatistician.  Build table shells and listing shells for the Biostatistician to review and quality control.  Require SAS Macro. STT520-420 9

10. Contract Research Organization (CRO) CRO = Contract Research Organization Most projects are the clinical trials from large pharmaceutical company. Local CRO: PPD; Quintiles; Kendle INC Research, and so on… STT520-420 10

11. Biostatistician Job hunting websites:  www.indeed.com www.indeed.com  www.biospace.com www.biospace.com  www.craigslist.org www.craigslist.org Other websites:  www.monster.com www.monster.com  www.careerbuilder.com www.careerbuilder.com http://monster.salary.com/SalaryWizard/Biostatistician-I-Salary-Details.aspx STT520-420 11