1. A B

2. Breast Case-Control Analysis CaseControl PC2<0.015028 PC2>0.013659 X-sq=10.7, df=1, p=0.001 OR=2.9 (1.6-5.5), p=0.00076 A B C D EF GO Terms - Survival PDGF signaling pathway (+) T cell activation (+) B cell activation (+) Angiogenesis (+) FDR p<0.0001 FDR p = 0.0001 - 0.001 FDR p = 0.001 - 0.01 FDR p = 0.01 - 0.05 GO Terms - Risk immune response (-) response to stimulus (-) cell-cell adhesion (+) immune system process (-) macrophage activation (-) FDR p = 0.001 - 0.01 FDR p = 0.01 - 0.05 FDR p = 0.05 - 0.20 (p<0.01)

3. Colon Case-Control Analysis A C CaseControl PC2<0.015750 PC2>0.013845 X-squared = 0.8, df = 1, p-value =0.38 OR=1.3 (0.75-2.4), p=0.38 GO Terms - Survival Angiogenesis (+) p53 pathway by glucose deprivation PDGF signaling pathway Integrin signalling pathway N-acetylglucosamine metabolism FDR p<0.0001 FDR p = 0.0001 - 0.001 FDR p = 0.001 - 0.01 FDR p = 0.01 - 0.05 FDR p > 0.05 (p<0.01) B D

4. P=0.007 P=0.040 P=0.265 P=0.149P=0.047 P=0.012 P=0.027 P=0.404 P=0.006 Breast Cancer EWASColon Cancer EWAS Pyrosequencing

5. P=0.002 P=0.018 P=5.66e-4 P=3.76e-5 P=0.009 P=1.97e-5 Colon Cancer EWAS Time Since Quitting Colon Cancer EWAS Length of Time Smoking

6. ABC NeverFormerCurrentNeverFormerCurrent DEF NeverFormerCurrentNeverFormerCurrentNeverFormerCurrent Breast Cancer EWASColon Cancer EWAS Pyrosequencing