1. Mainz - Germany

2. Dear Friends and Colleagues, It is our great pleasure to invite you to the autumn meeting of the “EORTC- Gastrointestinal Tract Cancer Collaborative Group". The primary purpose of this meeting is to accelerate our progress in the fight against GI cancer and to improve our international scientific collaborations between all European countries in this rapidly advancing field. This meeting will be hosted at the Haus Kupferberg at Kupferberg terrace, in close proximity of the University Hospital of Mainz. Here we will bring together all of you, i.e. gastroenterologists, oncologists, surgeons, radio-oncologists, laboratory scientists, pathologists, statisticians, EORTC representatives as well as colleagues from the pharmaceutical industry, providing the opportunity for a maximum of interaction and discussion. Within these two days, you will not only enjoy our hospitality but also be able to attend special social events. On Thursday and Friday evening you will have the opportunity to enjoy the beauty and the charm of the old Roman city of Mainz as well as the German wine garden Rheingau with the well known Eberbach Monastery, one of Europe’s first Cistercian settlements. The Symposium on Saturday morning will be held as official scientific meeting, so that our German and local colleagues can join us in our GI oncology lectures and our studies. We would be delighted if you could attend our EORTC GI group meeting and look forward to seeing you in Mainz/Frankfurt. Sincerely yours Markus Moehler Manfred Lutz Peter R. Galle Wolf O. Bechstein VENUE Thursday 8 th 1:00 p.m. EORTC GI board member meeting 2:00 p.m. Meetings of task force groups Colon cancer / Quality Assurance (only on invitation) 3:15 p.m. Imaging and pancreas cancer 4:30-6:00 p.m. Translational Research group meeting Sightseeing of Johannes Gutenberg Museum, Mainz Dinner Restaurant Mollers, at Staatstheater Mainz Gutenbergplatz Friday 9 th Scientific Group Meeting 9:00 -12:30 Part I (lunch) 1:30 - 4:30 Part II 5:00 - 6:00 p.m. Business meeting Rheingau Sightseeing and Dinner at Eberbach Monastery These meetings will be located at the Haus Kupferberg, Kupferberg terrace near Dorint Novotel Mainz, in walking distance from central station (Hauptbahnhof) and University hospital Saturday 10th Scientific Symposium 8.30 a.m. to 2:00 p.m. Hotel Hilton, Rheinallee, Mainz SECRETARY Mrs. Simone Becker Tel: +0049-6131-176839 - Fax: +0049-06131-176621 e-mail: becker@1-med.klinik.uni-mainz.de Gastrointestinal Tract Cancer Group

3. General Information and Services Scientific sessions: The European Organization for Research and Treatment of Cancer GI Group autumn meeting starts on 08 November 2007 and ends on 10 November 2007. Arrival at Mainz (close to Frankfurt (airport): At Frankfurt airport, taxis (~40-50€ one way) and train services (~10 €) are regularly available directly to Mainz city or Mainz central station. The Frankfurt airport is about a 30 min drive away from Mainz city (Autobahn). Hotel accommodation: We strongly recommend Hotel Römerwall, Hotel Mainzer Hof and Günnewig Bristol Hotel Language: The official language of the meeting is English. Dress code: For the gala dinner – business casual. Any other events – casual. Climate: The weather in Mainz/Frankfurt is continental. Warm clothes are recommended in November (5 o C). Rain showers may occur. Insurance: The organizers do not accept any responsibility for injuries or losses sustained by persons or personal belongings during the meeting. Participants are therefore strongly advised to carry appropriate travel and health insurance. Electricity supplies and telephone services: The two pin connecting plug (220 V) is similar to that used in a major part of EU (except UK). Coffee breaks: Coffee will be served during breaks. Certification of Attendance: Certificate of Attendance will be available at the registration desk. AGENDA OVERVIEW Thursday 08th November 13:00EORTC GI board member meeting Task forces,QA, TR group meetings 19:00 Sightseeing of the Gutenberg-Print-Museum Dinner (Restaurant Mollers, Gutenbergplatz 7, Mainz) Friday 09th November 09:00 - 12:30Group meeting - part 1 12:30 - 13:30Lunch 13:30 - 16:30Group meeting - part 2 17:00 - 18.00Business meeting Sightseeing /Dinner of Eberbach monastery Saturday 10th October 08:30 – 14:00Scientific Symposium Hotel Hilton Mainz and Lunch There is a possibility for a guided city tour according to expressed interest. For those who will stay Saturday night, a dinner will be organized. Gastrointestinal Tract Cancer Group

4. R E G I S T R A T I O N F O R M Prof.Dr.Mr.Mrs.Ms. Family name ____First name_____________ Adress________ CityCountryPostal code____ Institution________ PhoneFaxE-mail________ I WANT TO PARTICIPATE TO THE EORTC GI TRACT MEETING IN MAINZ Group meetings (some restricted) Yes  No  Scientific SymposiumYes  No  Social event on Thursday eveningYes  No  Social event on Friday eveningYes  No  Business meeting (restricted)Yes  No  Registration form should be sent to: Mrs. Simone Becker Tel: +0049 6131-17 6839 - Fax: +0049 6131-17 6621 e-mail: becker@1-med.klinik.uni-mainz.de Accompanying person(s) Mr. Ms. Family name First name Hotel reservation form find enclosed YOUR HOTEL RESERVATION SHOULD BE MADE DIRECTLY TO Touristik Center Mainz Brückenturm am Rathhaus 55116 Mainz, Germany Tel: + 49 (0)6131-286210/2862128 Fax: + 49 (0)6131-2862155 Gastrointestinal Tract Cancer Group

5. Program (preliminary) Innovative Study approaches Innovative Study Endpoints Galle / Popov / Arnold DC-enhanced MRIOberholzer PFS versus OSCollette Quality of life or clinical benefitConroy Innovative Translational Research Endpoints Aust / Lutz / Moehler Chemotherapy Stoehlmacher Targeted therapy Laurent-Puig Imaging Lordick Innovative therapeutic approaches Non-colorectal cancer Lang / Schmidberger / Haustermans Oesophageal cancer Schuhmacher Gastric cancer Roth Pancreatic cancer Van Laethem Colorectal cancer Nordlinger / Van Cutsem / Ruers Sequential versus combinationKoehne/Folprecht Perioperative therapy Bechstein Local therapyOtto Rectal cancerGlynne-Jones Other GI cancers Mitry GIST Hohenberger HCC Ducreux International Symposium EORTC GI Group Saturday 10. Nov. 2007 8:30 a.m. to 2:00 p.m. Hotel Hilton Rheinallee, Mainz