1. Beginning of the chapter Oxidative stress, substances and genetics (Toxo Sensor) 30

2. OXIDATIVE STRESS Free radicals damage the cells OXIDATIVE STRESS Free radicals AGEINGCANCER

3. OXIDATIVE STRESS Free radicals damage the cells CYTOPLASM OF A CELL Superoxide Hydrogen peroxide SOD2 SOD1 SOD3 5% oxygen MITOCHONDRIA

4. OXIDATIVE STRESS Free radicals

5. OXIDATIVE STRESS GPX1 – a selenoprotein GPX1 GPX1 Selenium Free radicals

6. OXIDATIVE STRESS GPX1 – a selenoprotein GPX1 GPX1 Selenium Free radicals

7. OXIDATIVE STRESS GPX1 – a selenoprotein GPX1 GPX1 Selenium

8. OXIDATIVE STRESS GPX1 – a selenoprotein GPX1 GPX1 Neutralised Selenium

9. OXIDATIVE STRESS Selenium deficiency and GPX1 Selenium deficiency 30% Activity More selenium 70% Activity

10. OXIDATIVE STRESS Polymorphism in the GPX1 gene GPX1 GPX1 Free radicals

11. OXIDATIVE STRESS GPX1 GPX1 Free radicals Selenium Polymorphism in the GPX1 gene

12. OXIDATIVE STRESS GPX1 GPX1 Poorer binding (for example, 50% worse) Selenium Polymorphism in the GPX1 gene

13. OXIDATIVE STRESS Normal levels of Selenium 35% Activity More selenium 60% Activity Polymorphism in the GPX1 gene

14. OXIDATIVE STRESS Free radicals

15. OXIDATIVE STRESS Coenzyme Q10 Q10 NQO1 UBIUBI Free radicals Q10 – No effect Ubiquinol antioxidant effect UBIUBI

16. OXIDATIVE STRESS Free radicals

17. OXIDATIVE STRESS Coenzyme Q10 Q10 NQO1 Free radicals Q10 – No effect Q10 UBIUBI UBIUBI UBIUBI UBIUBI UBIUBI UBIUBI UBIUBI

18. OXIDATIVE STRESS Coenzyme Q10 Q10 NQO1 Free radicals Q10 – No effect Q10 C C E E ALA C C E E E E C C E E

19. OXIDATIVE STRESS Oxidative stress, what to do now?

20. RECOMMENDATIONS 1)Antioxidant-rich diet 2)Additional intake of free-radical scavengers 1)Vitamin C 2)Vitamin E 3)ß-carotene 4)Alpha lipoic acid 5)Coenzyme Q10? Ubiquinol? 6)Selenium – how much? GPX1-gene 3)2 Cups of coffee/day for 7 delay of the breast cancer occurrence? OXIDATIVE STRESS Oxidative stress, what to do now?

21. SUBSTANCES The effect of various substances on our body

22. SUBSTANCES The effect of various substances on our body

23. End of the chapter Oxidative stress, substances and genetics (Toxo Sensor) 30